Generalized anxiety disorder and anorexia nervosa: evidence of shared genetic variation.

Abstract:

BACKGROUND:Previous studies have indicated a high prevalence of generalized anxiety disorder (GAD) in women with anorexia nervosa (AN). However, the shared genetic and environmental components of these disorders have not been explored. This study seeks to elucidate the shared genetic and environmental components between GAD and AN. METHOD:Using 2,083 women from the Virginia Adult Twin Study of Psychiatric and Substance Use Disorders, structural equation modeling was used to obtain maximum likelihood estimates of the environmental genetic, shared and unique environmental components in 496 women with GAD, 47 women with AN, 43 women with GAD + AN, and 1,497 women without GAD or AN. RESULTS:Results show that the heritability of GAD was 0.32 and AN was 0.31, and the genetic correlation between the two disorders was 0.20, indicating a modest genetic contribution to their comorbidity. Unique environment estimate was 0.68 for GAD and 0.69 for AN, with a unique environmental correlation of 0.18. All common environmental parameters were estimated at zero. CONCLUSIONS:The modest shared genetic and unique environmental liability to both disorders may help explain the high prevalence of GAD in women with AN. This knowledge could help in the treatment and prevention of comorbid disorders.

journal_name

Depress Anxiety

journal_title

Depression and anxiety

authors

Dellava JE,Kendler KS,Neale MC

doi

10.1002/da.20834

subject

Has Abstract

pub_date

2011-08-01 00:00:00

pages

728-33

issue

8

eissn

1091-4269

issn

1520-6394

journal_volume

28

pub_type

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