Escitalopram in the treatment of major depressive disorder in primary-care settings: an open-label trial.

Abstract:

BACKGROUND:The present trial was designed to assess the efficacy and safety of escitalopram prescribed to patients seeking treatment of major depressive disorder (MDD) in a Canadian primary-care setting. METHODS:Investigators (mainly primary-care physicians) enrolled patients with MDD from their daily practice. Patients were treated with escitalopram (flexible dose 10-20 mg/day) for up to 24 weeks. Efficacy assessments included the Montgomery-Asberg Depression Rating Scale (MADRS), the Clinical Global Impression-Improvement and -Severity scales (CGI-I, CGI-S), the Patient Global Evaluation (PGE), and the Medical Outcome Study 36-item Short Form (SF-36). RESULTS:Out of the 647 patients enrolled, 461 (71%) completed 24 weeks of treatment. The most common reason for discontinuation was adverse events (10%). The mean MADRS score decreased from 30.7 at baseline to 10.9 at the end of 24 weeks (last observation carried forward, LOCF). Remission (MADRS

journal_name

Depress Anxiety

journal_title

Depression and anxiety

authors

Chokka P,Legault M

doi

10.1002/da.20458

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

E173-81

issue

12

eissn

1091-4269

issn

1520-6394

journal_volume

25

pub_type

临床试验,杂志文章,多中心研究
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    pub_type: 杂志文章,评审

    doi:

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    pub_type: 杂志文章,多中心研究,随机对照试验

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