Abstract:
:In order to investigate the possible influence of norepinephrine (NE) on neuronal development, the effects of neonatal NE depletion on postnatally developing cell populations were characterized in (1) the normal mouse cerebellum, and (2) a cerebellar model system with delayed germinal cell development produced by neonatal methylazoxymethanol acetate (MAM) administration. Reduction in NE content was achieved by neonatal 6-hydroxydopamine (6-OHDA) injections. In the MAM-treated groups, 6-OHDA did not produce significant changes in external germinal layer (EGL) reconstitution. In the other groups, 6-OHDA treatment produced a reduction in the vermis area, alterations in foliation, and changes in the schedule of EGL development. These results support a role for NE in regulation of neuronal development in the cerebellum.
journal_name
Dev Neuroscijournal_title
Developmental neuroscienceauthors
Lovell KLdoi
10.1159/000112695subject
Has Abstractpub_date
1982-01-01 00:00:00pages
359-68issue
4eissn
0378-5866issn
1421-9859journal_volume
5pub_type
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更新日期:2019-03-12 00:00:00
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