Abstract:
:L-Ornithine decarboxylase (ODC), the rate-limiting enzyme of polyamine biosynthesis and thus a unique marker of the proliferation and maturation processes, has been localized by means of immunohistochemistry in the human central nervous system. The enzyme protein has not only been found in the developing nervous system but also in the adult brain. The first immunopositive neuroblasts occurred in the 15th week of gravidity, whereas an increasing number of structures in the medulla oblongata and cerebellum showed ODC immunoreactivity in weeks 18-24 of gravidity. ODC immunoreactivity was revealed in multiple neurons and in the ependymal lining of ventricles. In the adult human brain ODC immunoreactivity was found in the hippocampus and in the spinal cord. In no case were immunoreactive glial cells observed.
journal_name
Dev Neuroscijournal_title
Developmental neuroscienceauthors
Müller M,Pajunen AE,Järvinen M,Poeggel G,Bernstein HGdoi
10.1159/000111320subject
Has Abstractpub_date
1993-01-01 00:00:00pages
87-93issue
2eissn
0378-5866issn
1421-9859journal_volume
15pub_type
杂志文章abstract::Neuroblastoma is a childhood cancer caused by the transformation of sympathoadrenal progenitors. By following the formation of tumors in homozygous TH-MYCN mice, an established mouse model of neuroblastoma, we were able to capture transformed cells prior to the formation of large, vascularized tumors in order to deter...
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