Abstract:
:Birth asphyxia can result in sensory impairment, learning and memory deficits without gross brain injury and severe motor deficits. We developed a model of birth asphyxia resulting in mild neurological injury and cognitive impairment using a long-gestation species with precocial fetal development. Spiny mice (Acomys cahirinus) underwent caesarean-section delivery or 7.5 min of asphyxia at 37 days gestational age (term is 39 days). Brain histology was examined at 1 and 7 days of age, and behaviour was evaluated to 28 days of age. Asphyxiated offspring showed significant impairment in non-spatial memory and learning tasks, accompanied by central nervous system inflammation and increased apoptotic cell death but without the presence of large necrotic or cystic lesions.
journal_name
Dev Neuroscijournal_title
Developmental neuroscienceauthors
Hutton LC,Ratnayake U,Shields A,Walker DWdoi
10.1159/000251907subject
Has Abstractpub_date
2009-01-01 00:00:00pages
523-35issue
6eissn
0378-5866issn
1421-9859pii
000251907journal_volume
31pub_type
杂志文章abstract::α-Synuclein is one of the most abundant proteins in presynaptic terminals. Normal expression of α-synuclein is essential for neuronal survival and it prevents the initiation of apoptosis in neurons through covalent cross-linking of cytochrome c released from mitochondria. Exocytosis of α-synuclein occurs with neuronal...
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