Abstract:
:In adult rats, kainic acid-induced status epilepticus markedly reduces GluR2 (the alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid, AMPA subunit that limits Ca2+ permeability), receptor mRNA in the vulnerable CA3 and may contribute to delayed neurodegeneration. In rat pups resistant to kainate seizure-induced hippocampal neurodegeneration by silver impregnation, glutamate or GABA(A) alpha1-receptor mRNAs were unaltered in CA3 neurons 24 h after status epilepticus. In the dentate gyrus, GluR1 and GluR2 mRNAs were transiently increased in P14 but not P5 pups. Immunocytochemistry revealed no apparent differences in the distribution patterns of GluR1, GluR2, or GluR2/3 receptor proteins in the CA3 or dentate gyrus of P14 pups. Status epilepticus-induced alterations in receptor GluR2 and GABA(A) alphal mRNAs and AMPA protein expression vary with developmental age. Sustained expression at young ages may contribute to the resistance of developing hippocampal neurons to seizure-induced damage.
journal_name
Dev Neuroscijournal_title
Developmental neuroscienceauthors
Friedman LK,Sperber EF,Moshé SL,Bennett MV,Zukin RSdoi
10.1159/000111257subject
Has Abstractpub_date
1997-01-01 00:00:00pages
529-42issue
6eissn
0378-5866issn
1421-9859journal_volume
19pub_type
杂志文章abstract::In order to investigate the possible influence of norepinephrine (NE) on neuronal development, the effects of neonatal NE depletion on postnatally developing cell populations were characterized in (1) the normal mouse cerebellum, and (2) a cerebellar model system with delayed germinal cell development produced by neon...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112695
更新日期:1982-01-01 00:00:00
abstract::The auditory system of the cricket has the unusual ability to respond to deafferentation by compensatory growth and synapse formation. Auditory interneurons such as ascending neuron 2 (AN-2) in the cricket Gryllus bimaculatus possess a dendritic arbor that normally grows up to, but not over, the midline of the prothor...
journal_title:Developmental neuroscience
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journal_title:Developmental neuroscience
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journal_title:Developmental neuroscience
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doi:10.1159/000112449
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journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112092
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journal_title:Developmental neuroscience
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abstract::Traumatic brain injury (TBI) is predominantly a clinical problem of young persons, resulting in chronic cognitive and behavioral deficits. Specifically, the physiological response to a diffuse biomechanical injury in a maturing brain can clearly alter normal neuroplasticity. To properly evaluate and investigate develo...
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更新日期:2006-01-01 00:00:00
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journal_title:Developmental neuroscience
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journal_title:Developmental neuroscience
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journal_title:Developmental neuroscience
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更新日期:2006-01-01 00:00:00
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journal_title:Developmental neuroscience
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doi:10.1159/000112705
更新日期:1982-01-01 00:00:00
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journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111951
更新日期:1988-01-01 00:00:00
abstract::The rate of glutaminase-dependent metabolism of glutamine in intact astrocytes was determined under conditions in which the extracellular concentration of glutamine was varied between 0.2 and 3.2 mM glutamine for control and dibutyryl cyclic AMP (dBcAMP)-treated cells. Glutamine metabolism by intact cells increased wi...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111410
更新日期:1996-01-01 00:00:00
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journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111201
更新日期:1997-01-01 00:00:00
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journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112484
更新日期:1979-01-01 00:00:00
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journal_title:Developmental neuroscience
pub_type: 杂志文章
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更新日期:2005-01-01 00:00:00
abstract::We have previously shown that a single intracranial injection of apotransferrin (aTf) in neonatal rats produces an accelerated mylinogenesis and increases the expression of certain myelin proteins such as myelin basic protein (MBP). In the present work, we studied the effects of aTf upon oligodendrocyte progenitor cel...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000064945
更新日期:2002-01-01 00:00:00
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journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000232559
更新日期:2009-01-01 00:00:00
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journal_title:Developmental neuroscience
pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
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journal_title:Developmental neuroscience
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journal_title:Developmental neuroscience
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journal_title:Developmental neuroscience
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journal_title:Developmental neuroscience
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更新日期:2014-01-01 00:00:00
abstract::The postnatal developmental expression and the distribution of the glutamate transporters (GLAST, GLT-1 and EAAC1) were analyzed in rat vestibular nuclei (VN), at birth and during the following 4 weeks. Analyses were performed using reverse transcriptase-polymerase chain reaction and immunoblotting of GLAST, GLT-1 and...
journal_title:Developmental neuroscience
pub_type: 杂志文章
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更新日期:2003-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2004-03-01 00:00:00
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journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000017329
更新日期:1998-01-01 00:00:00
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journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
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