Abstract:
:The Notch signaling pathway is important at several stages of retinal development including the differentiation of retinal ganglion cells and Muller glia. The downstream effectors of Notch signaling, Hes1 and Hes5, have been shown to be critical in the retina as well. While Notch activity directly regulates Hes1 and Hes5 elsewhere in the nervous system, it has been unclear whether Hes1 and/or Hes5 are directly regulated by Notch activity in the developing retina. Here, we report that both Hes1 and Hes5 are directly regulated by Notch activity during retinal development. Using fluorescence-based Hes1 and Hes5 reporter constructs, we can monitor Notch activity in progenitor cells in the intact retina, and we find that Notch activity is downregulated just prior to retinal ganglion cell differentiation.
journal_name
Dev Neuroscijournal_title
Developmental neuroscienceauthors
Nelson BR,Gumuscu B,Hartman BH,Reh TAdoi
10.1159/000090759keywords:
subject
Has Abstractpub_date
2006-01-01 00:00:00pages
128-41issue
1-2eissn
0378-5866issn
1421-9859pii
90759journal_volume
28pub_type
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