Abstract:
:Developing neurons synthesize substantial quantities of membrane phospholipids in producing new synapses. We investigated the effects of maternal uridine (as uridine-5'-monophosphate) and docosahexaenoic acid supplementation on pups' brain phospholipids, synaptic proteins and dendritic spine densities. Dams consumed neither, 1 or both compounds for 10 days before parturition and 20 days while nursing. By day 21, brains of weanlings receiving both exhibited significant increases in membrane phosphatides, various pre- and postsynaptic proteins (synapsin-1, mGluR1, PSD-95), and in hippocampal dendritic spine densities. Administering these phosphatide precursors to lactating mothers or infants could be useful for treating developmental disorders characterized by deficient synapses.
journal_name
Dev Neuroscijournal_title
Developmental neuroscienceauthors
Cansev M,Marzloff G,Sakamoto T,Ulus IH,Wurtman RJdoi
10.1159/000193394subject
Has Abstractpub_date
2009-01-01 00:00:00pages
181-92issue
3eissn
0378-5866issn
1421-9859pii
000193394journal_volume
31pub_type
杂志文章abstract::Pediatric traumatic brain injury is a significant problem that affects many children each year. Progress is being made in developing neuroprotective strategies to combat these injuries. However, investigators are a long way from therapies to fully preserve injured neurons and glia. To restore neurological function, re...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000367784
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abstract::A glia-derived neurite-promoting factor has been purified from medium conditioned by C6 rat glioma cells. It induces neurite outgrowth in cultured mouse neuroblastoma cells and inhibits granule cell migration in explants of mouse cerebellum. This factor is a potent serine protease inhibitor which has recently been sho...
journal_title:Developmental neuroscience
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abstract::The rate of glutaminase-dependent metabolism of glutamine in intact astrocytes was determined under conditions in which the extracellular concentration of glutamine was varied between 0.2 and 3.2 mM glutamine for control and dibutyryl cyclic AMP (dBcAMP)-treated cells. Glutamine metabolism by intact cells increased wi...
journal_title:Developmental neuroscience
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abstract::Central nervous system (CNS) stem cells require epidermal growth factor (EGF) to survive and express glial-specific proteins (GSPs) under its influence. EGF and its receptor (EGF-R) therefore are involved in gliogenesis. We hypothesize that EGF selectively modulates GSP expression in pluripotential CNS cells and this ...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000048699
更新日期:2001-01-01 00:00:00
abstract::Various abnormalities in frontal and striatal regions have been reported in children with prenatal alcohol and/or methamphetamine exposure. In a recent fMRI study, we observed a correlation between accuracy on a working-memory task and functional activation in the putamen in children with prenatal methamphetamine and ...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000336242
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journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000360636
更新日期:2014-01-01 00:00:00
abstract::In vertebrate species, the neuropeptide oxytocin (OT) has been implicated in neural and behavioral development. Although several OT-like peptides have been characterized in invertebrate species, the ontogenesis of the OT-like system has not yet been described in these species. Thus, the aim of the present study was to...
journal_title:Developmental neuroscience
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journal_title:Developmental neuroscience
pub_type: 杂志文章
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journal_title:Developmental neuroscience
pub_type: 杂志文章
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更新日期:2000-01-01 00:00:00
abstract::Ethanol inhibition of L1-mediated cell adhesion may contribute to the spectrum of neurological, behavioral and morphological abnormalities associated with prenatal ethanol exposure. We showed previously that the neuroprotective peptides NAPVSIPQ (NAP) and SALLRSIPA (SAL) antagonize ethanol inhibition of L1 adhesion an...
journal_title:Developmental neuroscience
pub_type: 杂志文章
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更新日期:2005-01-01 00:00:00
abstract::Adult neuronal ceroid lipofuscinosis (NCL), also called Kufs' disease, is clinically distinct from the other NCLs. It is a rare condition which is difficult to diagnose. More than 50% of the reported cases of Kufs' disease are not adult NCL and correspond very likely to a heterogeneous spectrum of lipidoses. Various c...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000112182
更新日期:1991-01-01 00:00:00
abstract::The current work tested the hypothesis that the zinc status of a cell influences its sensitivity to iron-induced oxidative stress. Human IMR-32 neuroblastoma cells were cultured for 24 h in nonchelated control media (5 microM zinc; 4.5 microM iron), or in media that was treated with DTPA to reduce its zinc content (ch...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000065691
更新日期:2002-01-01 00:00:00
abstract::Neurite outgrowth is dependent on the presence in neurites of assembled microtubules which consist of polymerized tubulin to which microtubule-associated proteins (MAPs) are bound. This study adds to previous evidence of the similarity between the high molecular weight MAPs, MAP1X, MAP1B and MAP5, and explains the dif...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111318
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abstract::Neuronal heterotopia is a malformation of cortical development that is closely associated with epilepsy in humans. Despite emerging interest in the structure and function of the heterotopic cortex, little is known about the membrane properties and synaptic connections of these displaced neurons. We used whole-cell pat...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000017386
更新日期:1999-11-01 00:00:00
abstract::Neuroprotective cold-shock proteins (CSPs) are abundant in the normothermic neonatal rodent brain but decrease with advancing neurodevelopmental age and are low or absent in the adult brain. It has not been established if neurodevelopmental age alters the baseline expression of CSPs in the human brain. Here, we tested...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000493637
更新日期:2018-01-01 00:00:00
abstract::Early developmental processes, such as metabolic programming, can provide cues to an organism, which allow it to make modifications that are predicted to be beneficial for survival. Similarly, social play has a multifaceted role in promoting survival and fitness of animals. Play is a complex behavior that is greatly i...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000444015
更新日期:2016-01-01 00:00:00
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journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112301
更新日期:1985-01-01 00:00:00
abstract::Steroid hormones have profound effects on vertebrate behaviors. Yet, in most cases we can neither identify the neurons responsible for particular behaviors nor how steroids alter their excitability. Electric fish emit sexually dimorphic electric organ discharges (EODs) the waveform of which may be altered by steroid t...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000111399
更新日期:1996-01-01 00:00:00
abstract::Apoptosis contributes greatly to the morphological and biochemical features of cell death after neonatal cerebral hypoxia-ischemia (HI), making this mode of cell death a promising therapeutic target. We previously showed that 10 mg/kg of the caspase inhibitor Q-VD-OPh at the onset of and immediately after HI on postna...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000357939
更新日期:2014-01-01 00:00:00
abstract::NeuroD is a basic helix-loop-helix (bHLH) transcription factor cloned from a two hybrid screen designed to search for new bHLH proteins. In our previous studies, we showed that NeuroD could convert Xenopus ectoderm into fully differentiated neurons and that it could prematurely differentiate neural precursor cells in ...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
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更新日期:1997-01-01 00:00:00
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journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
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更新日期:2007-01-01 00:00:00
abstract::Stromal-derived factor 1 (SDF-1), a known chemoattractant, and its receptor CXCR4 are widely expressed in the developing and adult cerebral cortex. Recent studies have highlighted potential roles for SDF-1 during early cortical development. In view of the current findings, our histological analysis has revealed a dist...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000109857
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abstract::Neuroblastoma is a childhood cancer caused by the transformation of sympathoadrenal progenitors. By following the formation of tumors in homozygous TH-MYCN mice, an established mouse model of neuroblastoma, we were able to capture transformed cells prior to the formation of large, vascularized tumors in order to deter...
journal_title:Developmental neuroscience
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更新日期:2014-01-01 00:00:00
abstract::Astrocytes in primary cultures constitute an exceedingly useful preparation for studies of astroglial development and function. These cells, however, demonstrate a pronounced plasticity in their reactions to culturing conditions. Thus, species and spatiotemporal region of CNS chosen for source of cells, dissociation p...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000112295
更新日期:1985-01-01 00:00:00
abstract::It has been demonstrated that postweaning social isolation alters dendritic development in the medial prefrontal cortex (mPFC) of the rat. In addition, (-)-deprenyl, a monoamine oxidase B (MAO-B) inhibitor, promotes dendritic growth in prefrontocortical pyramidal cells. This study examined whether prefrontocortical de...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000096413
更新日期:2007-01-01 00:00:00
abstract::Proper eye formation depends on specific interactions between neural and ectodermal tissues coupled with temporally distinct gene expression and a regulated sequence of signaling events. The homeobox gene Pax6 is vitally important to the entire process of eye development in both vertebrates and invertebrates. Pax6 exp...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000082273
更新日期:2004-01-01 00:00:00
abstract::Disorders primarily affecting the nervous system comprise approximately one third of all established Mendelian genetic diseases in man. Recombinant DNA technology provides new approaches to the diagnosis and elucidation of the molecular pathology of these disorders. For a small but increasing number of disorders the D...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
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abstract::We have previously shown that lipopolysaccharide (LPS) sensitizes the immature rat brain to subsequent hypoxic-ischemic (HI) injury; however, the underlying mechanisms remain unclear. In this study, we examined the role of glucose in the sensitizing effects of LPS and lipoteichoic acid (LTA) in combination with HI in ...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000080713
更新日期:2004-01-01 00:00:00
abstract::When cells from the cerebellum of late-gestation rats were grown at low density (50-100 cells/mm2) in a three-dimensional culture system, they rapidly expressed morphological and electrophysiological properties of neurons. Growth and differentiation of the population of solitary neurons as a whole was statistically as...
journal_title:Developmental neuroscience
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abstract::The norepinephrine content of hypothalamus in vehicle-treated control rats gradually increases between days 16 and 45 of life. Norepinephrine contents of the hypothalamus and mesencephalon of the thyroxine-treated (10 microgram/g b.w., s.c., days 8-10) animals also increase between days 16 and 21. Mesencephalic and hy...
journal_title:Developmental neuroscience
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