Frontostriatal connectivity in children during working memory and the effects of prenatal methamphetamine, alcohol, and polydrug exposure.

Abstract:

:Various abnormalities in frontal and striatal regions have been reported in children with prenatal alcohol and/or methamphetamine exposure. In a recent fMRI study, we observed a correlation between accuracy on a working-memory task and functional activation in the putamen in children with prenatal methamphetamine and polydrug exposure. Because the putamen is part of the corticostriatal motor loop whereas the caudate is involved in the executive loop, we hypothesized that a loss of segregation between distinct corticostriatal networks may occur in these participants. The current study was designed to test this hypothesis using functional connectivity MRI. We examined 50 children ranging in age from 7 to 15, including 19 with prenatal methamphetamine exposure (15 of whom had concomitant prenatal alcohol exposure), 13 with prenatal exposure to alcohol but not methamphetamine, and 18 unexposed controls. We measured the coupling between blood oxygenation level dependent (BOLD) fluctuations during a working-memory task in four striatal seed regions and those in the rest of the brain. We found that the putamen seeds showed increased connectivity with frontal brain regions involved in executive functions while the caudate seeds showed decreased connectivity with some of these regions in both groups of exposed subjects compared to controls. These findings suggest that localized brain abnormalities resulting from prenatal exposure to alcohol and/or methamphetamine lead to a partial rewiring of corticostriatal networks. These results represent important progress in the field, and could have substantial clinical significance in helping devise more targeted treatments and remediation strategies designed to better serve the needs of this population.

journal_name

Dev Neurosci

authors

Roussotte FF,Rudie JD,Smith L,O'Connor MJ,Bookheimer SY,Narr KL,Sowell ER

doi

10.1159/000336242

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

43-57

issue

1

eissn

0378-5866

issn

1421-9859

pii

000336242

journal_volume

34

pub_type

杂志文章
  • Altered Hippocampal Gene Expression and Morphology in Fetal Piglets following Maternal Respiratory Viral Infection.

    abstract::Maternal infection during pregnancy increases the risk of neurobehavioral problems in offspring. Evidence from rodent models indicates that the maternal immune response to infection can alter fetal brain development, particularly in the hippocampus. However, information on the effects of maternal viral infection on fe...

    journal_title:Developmental neuroscience

    pub_type: 杂志文章

    doi:10.1159/000486850

    authors: Antonson AM,Balakrishnan B,Radlowski EC,Petr G,Johnson RW

    更新日期:2018-01-01 00:00:00

  • Ontogeny of oxytocin-like immunoreactivity in the cuttlefish, Sepia officinalis, central nervous system.

    abstract::In vertebrate species, the neuropeptide oxytocin (OT) has been implicated in neural and behavioral development. Although several OT-like peptides have been characterized in invertebrate species, the ontogenesis of the OT-like system has not yet been described in these species. Thus, the aim of the present study was to...

    journal_title:Developmental neuroscience

    pub_type: 杂志文章

    doi:10.1159/000235942

    authors: Bardou I,Maubert E,Leprince J,Chichery R,Dallérac G,Vaudry H,Agin V

    更新日期:2010-03-01 00:00:00

  • Optimizing Cerebral Autoregulation May Decrease Neonatal Regional Hypoxic-Ischemic Brain Injury.

    abstract:BACKGROUND:Therapeutic hypothermia provides incomplete neuroprotection for neonatal hypoxic-ischemic encephalopathy (HIE). We examined whether hemodynamic goals that support autoregulation are associated with decreased brain injury and whether these relationships are affected by birth asphyxia or vary by anatomic regio...

    journal_title:Developmental neuroscience

    pub_type: 杂志文章

    doi:10.1159/000452833

    authors: Lee JK,Poretti A,Perin J,Huisman TAGM,Parkinson C,Chavez-Valdez R,O'Connor M,Reyes M,Armstrong J,Jennings JM,Gilmore MM,Koehler RC,Northington FJ,Tekes A

    更新日期:2017-01-01 00:00:00

  • 'Hot spots' of creatine kinase localization in brain: cerebellum, hippocampus and choroid plexus.

    abstract::Creatine kinase (CK) isoenzymes, with emphasis on the mitochondrial CK isoenzymes, were characterized and localized in chicken cerebellum. Chicken cerebellum extracts analyzed by two-dimensional gels, using antipeptide antibodies specific for sarcomeric muscle-type mitochondrial CK (Mib-CK) and revealed the presence o...

    journal_title:Developmental neuroscience

    pub_type: 杂志文章,评审

    doi:10.1159/000111452

    authors: Kaldis P,Hemmer W,Zanolla E,Holtzman D,Wallimann T

    更新日期:1996-01-01 00:00:00

  • Role of mitochondria in neuronal apoptosis.

    abstract::Apoptosis is a controlled form of cell death that participates in the demise of neuronal cells during development, neurodegenerative disorders and exposure to neurotoxic agents. In recent years, the mitochondria have emerged as being pivotal in controlling apoptosis. They house a number of apoptogenic molecules that a...

    journal_title:Developmental neuroscience

    pub_type: 杂志文章,评审

    doi:10.1159/000017460

    authors: Gorman AM,Ceccatelli S,Orrenius S

    更新日期:2000-09-01 00:00:00

  • Immunohistochemical demonstration of L-ornithine decarboxylase enzyme protein in different areas of the developing human brain.

    abstract::L-Ornithine decarboxylase (ODC), the rate-limiting enzyme of polyamine biosynthesis and thus a unique marker of the proliferation and maturation processes, has been localized by means of immunohistochemistry in the human central nervous system. The enzyme protein has not only been found in the developing nervous syste...

    journal_title:Developmental neuroscience

    pub_type: 杂志文章

    doi:10.1159/000111320

    authors: Müller M,Pajunen AE,Järvinen M,Poeggel G,Bernstein HG

    更新日期:1993-01-01 00:00:00

  • Development of skeletal muscle sodium and potassium currents in zebrafish sofa potato mutants.

    abstract::In some cells, the development of voltage-gated channels requires synaptic input, while in others it does not. Here we investigate whether the sodium and potassium currents in the skeletal muscle of zebrafish sofa potato (sop(-/-)) mutants develop normally. Zebrafish sop(-/-) mutants do not express nicotinic acetylcho...

    journal_title:Developmental neuroscience

    pub_type: 杂志文章

    doi:10.1159/000207794

    authors: Coutts CA,Cunningham ME,Ali DW

    更新日期:2009-01-01 00:00:00

  • Neural stem cells in the immature, but not the mature, subventricular zone respond robustly to traumatic brain injury.

    abstract::Pediatric traumatic brain injury is a significant problem that affects many children each year. Progress is being made in developing neuroprotective strategies to combat these injuries. However, investigators are a long way from therapies to fully preserve injured neurons and glia. To restore neurological function, re...

    journal_title:Developmental neuroscience

    pub_type: 杂志文章

    doi:10.1159/000367784

    authors: Goodus MT,Guzman AM,Calderon F,Jiang Y,Levison SW

    更新日期:2015-01-01 00:00:00

  • Transcriptional Gene Silencing of the Autism-Associated Long Noncoding RNA MSNP1AS in Human Neural Progenitor Cells.

    abstract::The long noncoding RNA MSNP1AS (moesin pseudogene 1, antisense) is a functional element that was previously associated with autism spectrum disorder (ASD) with genome-wide significance. Expression of MSNP1AS was increased 12-fold in the cerebral cortex of individuals with ASD and 22-fold in individuals with a genome-w...

    journal_title:Developmental neuroscience

    pub_type: 杂志文章

    doi:10.1159/000453258

    authors: DeWitt JJ,Hecht PM,Grepo N,Wilkinson B,Evgrafov OV,Morris KV,Knowles JA,Campbell DB

    更新日期:2016-01-01 00:00:00

  • Attachment, survival and neurite extension of chick embryo retinal neurons on various culture substrates.

    abstract::Chick embryo retina neurons in culture extend neurites and form synapses. Seven different culture substrates were compared to determine which culture surface would produce the best neuronal survival and neurite extension. The order of survival of retina neurons during 7 days of culture is salt-precipitated collagen gr...

    journal_title:Developmental neuroscience

    pub_type: 杂志文章

    doi:10.1159/000112705

    authors: Thompson JM,Pelto DJ

    更新日期:1982-01-01 00:00:00

  • Chronic neurological deficits in mice after perinatal hypoxia and ischemia correlate with hemispheric tissue loss and white matter injury detected by MRI.

    abstract::We investigated the effects of perinatal hypoxia-ischemia (HI) on brain injury and neurological functional outcome at postnatal day (P)30 through P90. HI was induced by exposing P9 mice to 8% O(2) for 55 min using the Vannucci HI model. Following HI, mice were treated with either vehicle control or Na(+)/H(+) exchange...

    journal_title:Developmental neuroscience

    pub_type: 杂志文章

    doi:10.1159/000328430

    authors: Cengiz P,Uluc K,Kendigelen P,Akture E,Hutchinson E,Song C,Zhang L,Lee J,Budoff GE,Meyerand E,Sun D,Ferrazzano P

    更新日期:2011-01-01 00:00:00

  • Cytoskeletal characterization of a neuroectodermal cell line and embryonic mouse brain.

    abstract::The cytoskeleton of a newly isolated mouse embryo brain-derived cell line and of dissected mesencephalon-rhombencephalon samples of the 10- to 11-day-old mouse embryo, constituted of a ventricular zone only, has been examined by immunocytochemistry, electrophoretic separation and Western blotting techniques. In accord...

    journal_title:Developmental neuroscience

    pub_type: 杂志文章

    doi:10.1159/000111612

    authors: Zákány J,Murach KF,Fundele R,Illmensee K

    更新日期:1987-01-01 00:00:00

  • Focal cortical dysplasia in children.

    abstract::Cortical dysplasia (CD) is now recognized as one of the major causes of pediatric focal neocortical epilepsy, and surgical procedures have been considered early in life. However, the mechanisms involved in seizure generation and intractability in these patients are still unknown. We analyzed with immunocytochemistry f...

    journal_title:Developmental neuroscience

    pub_type: 杂志文章

    doi:10.1159/000017406

    authors: Hilbig A,Babb TL,Najm I,Ying Z,Wyllie E,Bingaman W

    更新日期:1999-11-01 00:00:00

  • Plasticity of astrocytes in primary cultures: an experimental tool and a reason for methodological caution.

    abstract::Astrocytes in primary cultures constitute an exceedingly useful preparation for studies of astroglial development and function. These cells, however, demonstrate a pronounced plasticity in their reactions to culturing conditions. Thus, species and spatiotemporal region of CNS chosen for source of cells, dissociation p...

    journal_title:Developmental neuroscience

    pub_type: 杂志文章,评审

    doi:10.1159/000112295

    authors: Juurlink BH,Hertz L

    更新日期:1985-01-01 00:00:00

  • Glial disturbances in isolated neocortex: evidence from immunohistochemistry of intraocular grafts.

    abstract::Cortex cerebri pieces from fetal donors were homologously and bilaterally grafted to the anterior eye chamber of adult albino rats. After intraocular maturation, presence of an external glial membrane, glial membranes surrounding blood vessels and cortical astrocytes was demonstrated using antisera raised against glia...

    journal_title:Developmental neuroscience

    pub_type: 杂志文章

    doi:10.1159/000112703

    authors: Björklund H,Dahl D

    更新日期:1982-01-01 00:00:00

  • Dynamic patterned expression of orphan nuclear receptor genes RORalpha and RORbeta in developing mouse forebrain.

    abstract::As a step toward using two closely related members of the nuclear receptor family, RORalpha and RORbeta, as markers and tools for genetic manipulations in mouse forebrain, we have used in situ hybridization to analyze their expression from E10.5 to P7. At later embryonic and early postnatal ages, RORalpha expression i...

    journal_title:Developmental neuroscience

    pub_type: 杂志文章

    doi:10.1159/000072271

    authors: Nakagawa Y,O'Leary DD

    更新日期:2003-03-01 00:00:00

  • 5-Hydroxytryptamine 1A and 2B serotonin receptors in neurite outgrowth: involvement of early growth response protein 1.

    abstract::Neurotransmitters play important roles in neurogenesis; in particular, acetylcholine and serotonin may regulate neurite elongation. Acetylcholine may also activate transcription factors such as early growth response protein 1 (EGR-1), which plays a role in neurite extension. N18TG2 neuroblastoma cells (which do not pr...

    journal_title:Developmental neuroscience

    pub_type: 杂志文章

    doi:10.1159/000354423

    authors: Anelli T,Cardarelli S,Ori M,Nardi I,Biagioni S,Poiana G

    更新日期:2013-01-01 00:00:00

  • Infants Uniquely Express High Levels of RBM3 and Other Cold-Adaptive Neuroprotectant Proteins in the Human Brain.

    abstract::Neuroprotective cold-shock proteins (CSPs) are abundant in the normothermic neonatal rodent brain but decrease with advancing neurodevelopmental age and are low or absent in the adult brain. It has not been established if neurodevelopmental age alters the baseline expression of CSPs in the human brain. Here, we tested...

    journal_title:Developmental neuroscience

    pub_type: 杂志文章

    doi:10.1159/000493637

    authors: Jackson TC,Kotermanski SE,Kochanek PM

    更新日期:2018-01-01 00:00:00

  • Correlation of diffusion tensor imaging with histology in the developing human frontal cerebrum.

    abstract::Transient early cerebral laminar organization resulting from normal developmental events has been revealed in human beings through histology and imaging studies. DTI studies have postulated that the fractional anisotropy (FA)-based differentiation of different laminar structures reflects both differing cellular densit...

    journal_title:Developmental neuroscience

    pub_type: 杂志文章

    doi:10.1159/000229500

    authors: Trivedi R,Husain N,Rathore RK,Saksena S,Srivastava S,Malik GK,Das V,Pradhan M,Pandey CM,Gupta RK

    更新日期:2009-01-01 00:00:00

  • Cerebellar soluble lectin is responsible for cell adhesion and participates in myelin compaction in cultured rat oligodendrocytes.

    abstract::Cultures of rat oligodendrocytes were used to test the possible role of the cerebellar soluble lectin (CSL) in myelin formation. Immunocytochemistry at the ultrastructural level showed that the lectin is present in the cytoplasm of the perikaryon of cultured oligodendrocytes and also on the plasma membrane of the cell...

    journal_title:Developmental neuroscience

    pub_type: 杂志文章

    doi:10.1159/000111970

    authors: Kuchler S,Fressinaud C,Sarlieve LL,Vincendon G,Zanetta JP

    更新日期:1988-01-01 00:00:00

  • Effect of colchicine on ganglioside composition of rat primary culture neurons.

    abstract::Developmental changes in gangliosides in the course of neurite outgrowth were examined in dissociated fetal rat cerebral neurons in culture. About a 2-fold increase in ganglioside levels was seen with the progression of neurite formation for up to 24 h in predominantly neuronal cultures. Ganglioside patterns appeared ...

    journal_title:Developmental neuroscience

    pub_type: 杂志文章

    doi:10.1159/000111647

    authors: Ogiso M,Ohta M,Harada Y,Hirano S

    更新日期:1992-01-01 00:00:00

  • Auditory deficits associated with the frings mgr1 (mass1) mutation in mice.

    abstract::The gene responsible for the audiogenic seizure (AGS) phenotype in Frings mice, which was identified and originally designated Mass1, is now referred to as Mgr1. Although the function of the gene product is not known, the expression pattern suggests a role in the developing CNS. Hearing impairment is often observed in...

    journal_title:Developmental neuroscience

    pub_type: 杂志文章

    doi:10.1159/000086712

    authors: Klein BD,Fu YH,Ptacek LJ,White HS

    更新日期:2005-01-01 00:00:00

  • HIV-1 and the developing human nervous system: in vivo and in vitro aspects.

    abstract::HIV-1 is able to penetrate the developing human central nervous system and induce damage. Clinical and neuropathological observations demonstrate that (a) the virus is transmitted during the late phase of pregnancy or at the time of delivery; (b) the main infected cells within the brain are macrophages, and (c) the me...

    journal_title:Developmental neuroscience

    pub_type: 杂志文章,评审

    doi:10.1159/000112100

    authors: Tardieu M,Janabi N

    更新日期:1994-01-01 00:00:00

  • Developmental effects of prenatal cocaine exposure on 5-HT1A receptors in male and female rat offspring.

    abstract::Prenatal cocaine exposure results in behavioral abnormalities throughout development in rats, but little is known regarding the biological mechanisms underlying these abnormalities. Pregnant rats received subcutaneous twice-daily injections (1 ml/kg) of normal saline or 15 mg/kg of cocaine hydrochloride throughout ges...

    journal_title:Developmental neuroscience

    pub_type: 杂志文章

    doi:10.1159/000069363

    authors: Johns JM,Lubin DA,Lieberman JA,Lauder JM

    更新日期:2002-01-01 00:00:00

  • Development of cortical fibres into the gracile nucleus of the rat: an ultrastructural study.

    abstract::A study was made on the development of cortical synapses in the gracile nucleus of rats using degeneration methods. A total of 46 animals, 1 adult and 45 neonates whose ages varied from 1 to 7 days, had the right somatosensory motor cortex destroyed. The survival period varied from 1 to 30 days. Identification of axon...

    journal_title:Developmental neuroscience

    pub_type: 杂志文章

    doi:10.1159/000112118

    authors: Chimelli L,Bello AR,Scaravilli F

    更新日期:1994-01-01 00:00:00

  • A developmental model for studying choline acetyltransferase transport in chick motoneurons.

    abstract::The proximodistal axonal transport of choline acetyltransferase (ChAc) has been studied in the chick sciatic nerve in the absence of any experimental manipulation. The phenomenon utilized by us is a physiological transient fall in the activity of ChAc. This fall occurs in most areas of the chick central nervous system...

    journal_title:Developmental neuroscience

    pub_type: 杂志文章

    doi:10.1159/000112484

    authors: Giacobini G,Cannas M,Panattoni GL,Filogamo G

    更新日期:1979-01-01 00:00:00

  • Evidence for regulation of myelin protein synthesis by contact between adjacent Schwann cell plasma membranes.

    abstract::The spontaneously immortalized S16 Schwann cell line expresses higher levels of myelin-associated glycoprotein (MAG) and PO glycoprotein and their messenger RNAs when grown at high density than at low density [Sasagasako et al: J Neurochem 1996;66:1432-1439]. This up-regulation of myelin protein expression at high den...

    journal_title:Developmental neuroscience

    pub_type: 杂志文章

    doi:10.1159/000017409

    authors: Sasagasako N,Ohno M,Quarles RH

    更新日期:1999-01-01 00:00:00

  • Expression of cell surface markers and myelin proteins in cultured oligodendrocytes from neonatal brain of rat and mouse: a comparative study.

    abstract::Dissociated brain cell cultures are a useful model for investigating development and differentiation of oligodendrocytes in vitro. The current studies compare the developmental patterns of expression for oligodendrocyte lineage/myelin markers in both primary and secondary oligodendrocyte cultures derived from mouse an...

    journal_title:Developmental neuroscience

    pub_type: 杂志文章

    doi:10.1159/000111276

    authors: Duchala CS,Asotra K,Macklin WB

    更新日期:1995-01-01 00:00:00

  • Ischemic-Reperfusion Injury Increases Matrix Metalloproteinases and Tissue Metalloproteinase Inhibitors in Fetal Sheep Brain.

    abstract::Hypoxic-ischemic brain injury is a leading cause of neurodevelopmental morbidities in preterm and full-term infants. Blood-brain barrier dysfunction represents an important component of perinatal hypoxic-ischemic brain injury. The extracellular matrix (ECM) is a vital component of the blood-brain barrier. Matrix metal...

    journal_title:Developmental neuroscience

    pub_type: 杂志文章

    doi:10.1159/000489700

    authors: Chen X,Patra A,Sadowska GB,Stonestreet BS

    更新日期:2018-01-01 00:00:00

  • Postnatal development of the primate hippocampal formation.

    abstract::The hippocampal formation is a multicomponent region of the medial temporal lobe preferentially involved in declarative and relational memory processing. Behavioral studies have suggested a protracted functional maturation of these structures in primates, and postnatal developmental abnormalities in the hippocampal fo...

    journal_title:Developmental neuroscience

    pub_type: 杂志文章,评审

    doi:10.1159/000096222

    authors: Lavenex P,Banta Lavenex P,Amaral DG

    更新日期:2007-01-01 00:00:00