Abstract:
:We have previously provided evidence that ferritin binds selectively to white matter tracts in adult mouse and human brains. In cell culture experiments, ferritin binding is specifically localized to oligodendrocytes. The goal of the present study is to test the hypothesis that the developmental pattern for ferritin binding will coincide with the onset and progression of myelination. The first evidence of ferritin binding in the mouse brain is at 12 days of age and occurs within the brainstem. Ferritin binding persisted in the brainstem and expanded to the corpus callosum by 15-16 days of age. By 23-24 days of age ferritin binding had further extended to the striatal white matter. By adulthood, ferritin binding was strongly and selectively expressed throughout all white matter tracts. To begin to identify which factors may be involved in the induction of ferritin-binding proteins on oligodendrocytes, brains from the myelin mutant jimpy mice and unaffected littermates were examined at postnatal days 16-18. Jimpy mice were chosen because their oligodendrocytes fail to produce myelin or accumulate iron. Thus, using jimpy mice would elucidate whether these factors are necessary for ferritin-binding protein expression. Both the jimpy mutants and their controls exhibited saturable ferritin binding with similar binding densities and dissociation constants. Dissociation constants for ferritin binding in the unaffected littermates and jimpy mutant mice were 0.38 +/- 0.04 and 0.32 +/- 0.06 nM, respectively and binding densities were similar (1.1 +/- 0.09 and 0.96 +/- 0.12 fmol/mg, respectively). Our results demonstrate that expression of ferritin binding is dependent on the age of the oligodendrocytes and not dependent upon iron accumulation by oligodendrocytes or myelin production. We propose that iron delivery to oligodendrocytes is predominantly via ferritin and this method of iron uptake is unique to oligodendrocytes in the brain.
journal_name
Dev Neuroscijournal_title
Developmental neuroscienceauthors
Hulet SW,Menzies S,Connor JRdoi
10.1159/000065704keywords:
subject
Has Abstractpub_date
2002-01-01 00:00:00pages
208-13issue
2-3eissn
0378-5866issn
1421-9859pii
65704journal_volume
24pub_type
杂志文章abstract::There is an important unmet need to further improve the outcome of neonatal encephalopathy in term infants. Meta-analyses of large controlled trials now suggest that maternal magnesium sulfate (MgSO4) therapy is associated with a reduced risk of cerebral palsy and gross motor dysfunction after premature birth, but tha...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000362206
更新日期:2014-01-01 00:00:00
abstract::Cerebral metabolism is known to be highly dependent upon glucose utilisation. In the neonate, severe hypoglycaemia is now recognized to be associated with subsequent adverse neurodevelopment and in extremis glial and neuronal cell death. However, the level at which hypoglycaemia becomes clinically important is not wel...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000112124
更新日期:1994-01-01 00:00:00
abstract::The incidence of stroke in children is 2.4 per 100,000 person-years and results in long-term motor and cognitive disability. In ischemic stroke, white matter (WM) is frequently injured, but is relatively understudied compared to grey matter injury. Previous research suggests that the cellular response to WM ischemic i...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000496200
更新日期:2019-03-12 00:00:00
abstract::In the developing brain the majority of neurons migrate from their birthplace to their final destination. This active movement is essential for the formation of cortical layers and nuclei. The impairment of migration does not affect the viability of neurons but often results in abnormal differentiation. The proper mig...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000109847
更新日期:2008-01-01 00:00:00
abstract::The spontaneously immortalized S16 Schwann cell line expresses higher levels of myelin-associated glycoprotein (MAG) and PO glycoprotein and their messenger RNAs when grown at high density than at low density [Sasagasako et al: J Neurochem 1996;66:1432-1439]. This up-regulation of myelin protein expression at high den...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000017409
更新日期:1999-01-01 00:00:00
abstract::This study investigated the time of expression of two endothelial cell adhesion molecules, ICAM-1/CD54 and PECAM-1/CD31 in the developing postpartum mouse blood-brain barrier (BBB). Immunoultrastructural studies demonstrated that both adhesion molecules are initially expressed primarily on the luminal endothelial cell...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000017352
更新日期:1998-01-01 00:00:00
abstract::Birth asphyxia can result in sensory impairment, learning and memory deficits without gross brain injury and severe motor deficits. We developed a model of birth asphyxia resulting in mild neurological injury and cognitive impairment using a long-gestation species with precocial fetal development. Spiny mice (Acomys c...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000251907
更新日期:2009-01-01 00:00:00
abstract::Uncertainty reigns over whether or not glutamate uptake in astrocytes leads to strong stimulation of glucose utilization, measured as accumulation of radioactive deoxyglucose-6-phosphate. This is an important issue, not only because glutamate is the major excitatory transmitter, but also because it has been postulated...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000017329
更新日期:1998-01-01 00:00:00
abstract::α-Synuclein is one of the most abundant proteins in presynaptic terminals. Normal expression of α-synuclein is essential for neuronal survival and it prevents the initiation of apoptosis in neurons through covalent cross-linking of cytochrome c released from mitochondria. Exocytosis of α-synuclein occurs with neuronal...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000321342
更新日期:2010-01-01 00:00:00
abstract::The neonatal rat model of unilateral cerebral hypoxia-ischemia (HI) is commonly used to test the efficacy of therapeutic strategies for prevention or treatment of stroke in the immature brain. Traditionally neuroprotection has been defined as reduction in tissue injury; there is growing interest in complementary funct...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000075665
更新日期:2003-11-01 00:00:00
abstract::Neurotoxicological studies have indicated that L-glutamate exhibits more pronounced effects on the preoptic area (POA) neurons of male rats than on those of females in the neonatal period. However, no information has previously been available as to whether or not such sexual dimorphism also exists for the effects of g...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000048726
更新日期:2001-01-01 00:00:00
abstract::The neurochemical effect of postnatal exposure to methadone (METH), undernutrition (UND), and methadone and undernutrition (METH-UND) on the whole brain and cerebellum were examined in 21- and 60-day-old rats. At 21 days, body weight reductions of UND and METH-UND rats exceeded that of the METH animals. However, METH ...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112698
更新日期:1982-01-01 00:00:00
abstract::It has been demonstrated that postweaning social isolation alters dendritic development in the medial prefrontal cortex (mPFC) of the rat. In addition, (-)-deprenyl, a monoamine oxidase B (MAO-B) inhibitor, promotes dendritic growth in prefrontocortical pyramidal cells. This study examined whether prefrontocortical de...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000096413
更新日期:2007-01-01 00:00:00
abstract::Creatine kinase (CK) isoenzymes, with emphasis on the mitochondrial CK isoenzymes, were characterized and localized in chicken cerebellum. Chicken cerebellum extracts analyzed by two-dimensional gels, using antipeptide antibodies specific for sarcomeric muscle-type mitochondrial CK (Mib-CK) and revealed the presence o...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000111452
更新日期:1996-01-01 00:00:00
abstract::In order to investigate the possible influence of norepinephrine (NE) on neuronal development, the effects of neonatal NE depletion on postnatally developing cell populations were characterized in (1) the normal mouse cerebellum, and (2) a cerebellar model system with delayed germinal cell development produced by neon...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112695
更新日期:1982-01-01 00:00:00
abstract::Reactive oxygen species (ROS) have been reported to affect neural stem cell self-renewal and therefore may be important for normal development and may influence neurodegenerative processes when ROS activity is elevated. To determine if increasing production of superoxide, via activation of NADPH oxidase (Nox), increas...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000350502
更新日期:2013-01-01 00:00:00
abstract::L-Ornithine decarboxylase (ODC), the rate-limiting enzyme of polyamine biosynthesis and thus a unique marker of the proliferation and maturation processes, has been localized by means of immunohistochemistry in the human central nervous system. The enzyme protein has not only been found in the developing nervous syste...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111320
更新日期:1993-01-01 00:00:00
abstract::Apoptosis contributes greatly to the morphological and biochemical features of cell death after neonatal cerebral hypoxia-ischemia (HI), making this mode of cell death a promising therapeutic target. We previously showed that 10 mg/kg of the caspase inhibitor Q-VD-OPh at the onset of and immediately after HI on postna...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000357939
更新日期:2014-01-01 00:00:00
abstract::Disorders primarily affecting the nervous system comprise approximately one third of all established Mendelian genetic diseases in man. Recombinant DNA technology provides new approaches to the diagnosis and elucidation of the molecular pathology of these disorders. For a small but increasing number of disorders the D...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000112346
更新日期:1983-01-01 00:00:00
abstract::A study was made on the development of cortical synapses in the gracile nucleus of rats using degeneration methods. A total of 46 animals, 1 adult and 45 neonates whose ages varied from 1 to 7 days, had the right somatosensory motor cortex destroyed. The survival period varied from 1 to 30 days. Identification of axon...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112118
更新日期:1994-01-01 00:00:00
abstract::We have shown that the developmentally regulated appearance of the two myelin-associated glycoprotein (MAG) polypeptides in normal mouse brain myelin does not reflect the developmental pattern of differential splicing of primary gene transcripts as determined earlier by RNase protection assays. Contrary to expectation...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111857
更新日期:1990-01-01 00:00:00
abstract::In cultured glial cells from chick embryonic brain, both influx and efflux of 42K+ and 22Na+ are dependent on the external Ca++ and concentration ([Ca++]0) between 2 and 0.1 mM although intracellular concentrations of K+ ([K+]i) and Na+ ([Na+]i) do not change. Only a reduction of [Ca++]0 below 0.1 mM results in both a...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112664
更新日期:1982-01-01 00:00:00
abstract::Three experimental approaches were used to examine the maturation of N-methyl-D-aspartate (NMDA) receptors in the neostriatum and compare their developmental profile to that of the non-NMDA receptors [alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and kainate (KA)]. The first, and least conventional ...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000017310
更新日期:1998-01-01 00:00:00
abstract::We studied the developmental changes of soluble and membrane-bound protein kinases (EC 2.7.1.37) in rat brain and found that the elution profiles from a DEAE-cellulose column by NaCl of adenosine-3':5'-monophosphate (cyclic AMP) dependent protein kinase from cytosol were not significantly different in newborn (0.19 M ...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112450
更新日期:1979-01-01 00:00:00
abstract::Early developmental treatment of rats with 3,4-methylenedioxymethamphetamine (MDMA) was previously found to cause an abnormal pattern of forebrain serotonergic axon density in adulthood consisting of a cortical hypoinnervation and a striatal hyperinnervation. The present study tested the hypothesis that this reorganiz...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000207497
更新日期:2009-01-01 00:00:00
abstract::Ethanol inhibition of L1-mediated cell adhesion may contribute to the spectrum of neurological, behavioral and morphological abnormalities associated with prenatal ethanol exposure. We showed previously that the neuroprotective peptides NAPVSIPQ (NAP) and SALLRSIPA (SAL) antagonize ethanol inhibition of L1 adhesion an...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000084528
更新日期:2005-01-01 00:00:00
abstract::Fragile X syndrome (FXS) is a neurodevelopmental disorder characterized by intellectual disability, sensory hypersensitivity, and high incidences of autism spectrum disorders and epilepsy. These phenotypes are suggestive of defects in neural circuit development and imbalances in excitatory glutamatergic and inhibitory...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000329420
更新日期:2011-01-01 00:00:00
abstract::All known actions of cAMP in the brain require cAMP-dependent protein kinase (cAMPdPK), which consists of regulatory (R) and catalytic (C) subunits (R2C2). Using homologous rat cDNAs for all known cAMPdPK subunit isoforms found in the brain (RI alpha, RI beta, RII alpha, RII beta, C alpha, C beta) we observe that, in ...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112140
更新日期:1991-01-01 00:00:00
abstract::Cortex cerebri pieces from fetal donors were homologously and bilaterally grafted to the anterior eye chamber of adult albino rats. After intraocular maturation, presence of an external glial membrane, glial membranes surrounding blood vessels and cortical astrocytes was demonstrated using antisera raised against glia...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112703
更新日期:1982-01-01 00:00:00
abstract::Previous studies have demonstrated that exposure to ethanol during development delays the rate at which axons in certain central nervous system tracts acquire myelin. This delay appears to be related to an alteration in oligodendrocyte function and not to an aberrancy in axon size or number. The present study was desi...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112154
更新日期:1991-01-01 00:00:00