Abstract:
:The distal segments of the crush-injured and permanently transected sciatic nerve provide models to study Schwann cell activity in the presence and absence of Schwann cell-axonal contact, respectively. We examined the quantity and quality of transcript coding for the myelin-associated glycoprotein (MAG) over a 3-week period following crush injury and at 35 days after transection to investigate possible regulation of this gene during nerve injury and subsequent repair. Northern blot and slot blot analysis indicated a sharp decrease in levels of MAG mRNA 2 days after crush injury which was followed by a progressive increase in levels of message between 7 and 21 days after injury. Western blot analysis showed that levels of MAG protein decreased substantially 7 days after crush injury, which returned to 70% of the adult value by 21 days after injury. MAG mRNA and protein were undetectable by Northern and Western analysis, respectively, in the distal segment of the sciatic nerve 35 days after permanent transection. This infers distinct down-regulation of MAG gene expression after permanent transection of a peripheral nerve. These comparative studies of MAG transcripts and encoded protein may indicate regulation of MAG gene expression at the level of transcription, and possibly at the level of post-transcription in these experimental models of peripheral neuropathies.
journal_name
Dev Neuroscijournal_title
Developmental neuroscienceauthors
Gupta SK,Poduslo JF,Dunn R,Roder J,Mezei Cdoi
10.1159/000111832subject
Has Abstractpub_date
1990-01-01 00:00:00pages
22-33issue
1eissn
0378-5866issn
1421-9859journal_volume
12pub_type
杂志文章abstract::A study was made on the development of cortical synapses in the gracile nucleus of rats using degeneration methods. A total of 46 animals, 1 adult and 45 neonates whose ages varied from 1 to 7 days, had the right somatosensory motor cortex destroyed. The survival period varied from 1 to 30 days. Identification of axon...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112118
更新日期:1994-01-01 00:00:00
abstract::Developmental changes in gangliosides in the course of neurite outgrowth were examined in dissociated fetal rat cerebral neurons in culture. About a 2-fold increase in ganglioside levels was seen with the progression of neurite formation for up to 24 h in predominantly neuronal cultures. Ganglioside patterns appeared ...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111647
更新日期:1992-01-01 00:00:00
abstract::This study analyzed the role of dopamine D1 and D2 receptors in methylphenidate (MPH) conditioned place preference (CPP) in adolescent male and female rats, in addition to the role of these receptors in the effects of MPH on brain-derived neurotrophic factor (BDNF) in the dorsal striatum and nucleus accumbens. Using a...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000360636
更新日期:2014-01-01 00:00:00
abstract::In adult rats, kainic acid-induced status epilepticus markedly reduces GluR2 (the alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid, AMPA subunit that limits Ca2+ permeability), receptor mRNA in the vulnerable CA3 and may contribute to delayed neurodegeneration. In rat pups resistant to kainate seizure-induced...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111257
更新日期:1997-01-01 00:00:00
abstract::Glutamine synthesis, the major pathway of ammonia detoxification, and the intracellular concentration of organic osmolytes in primary astrocytes and F98 glioma cells were investigated with multinuclear magnetic resonance spectroscopy. Acute exposure to ammonia (3 h incubation with NH4Cl) raised the concentration of gl...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000017339
更新日期:1998-01-01 00:00:00
abstract::Autism spectrum disorder (ASD) comprises a group of neurodevelopmental disorders characterized by social deficits and stereotyped behaviors. While several theories have emerged, the pathogenesis of ASD remains unknown. Although studies report dopamine signaling abnormalities in autistic patients, a coherent dopamine h...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000478725
更新日期:2017-01-01 00:00:00
abstract::Pediatric traumatic brain injury is a significant problem that affects many children each year. Progress is being made in developing neuroprotective strategies to combat these injuries. However, investigators are a long way from therapies to fully preserve injured neurons and glia. To restore neurological function, re...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000367784
更新日期:2015-01-01 00:00:00
abstract::When cells from the cerebellum of late-gestation rats were grown at low density (50-100 cells/mm2) in a three-dimensional culture system, they rapidly expressed morphological and electrophysiological properties of neurons. Growth and differentiation of the population of solitary neurons as a whole was statistically as...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111645
更新日期:1992-01-01 00:00:00
abstract::Maternal infection during pregnancy increases the risk of neurobehavioral problems in offspring. Evidence from rodent models indicates that the maternal immune response to infection can alter fetal brain development, particularly in the hippocampus. However, information on the effects of maternal viral infection on fe...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000486850
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Therapeutic hypothermia provides incomplete neuroprotection for neonatal hypoxic-ischemic encephalopathy (HIE). We examined whether hemodynamic goals that support autoregulation are associated with decreased brain injury and whether these relationships are affected by birth asphyxia or vary by anatomic regio...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000452833
更新日期:2017-01-01 00:00:00
abstract::Early developmental processes, such as metabolic programming, can provide cues to an organism, which allow it to make modifications that are predicted to be beneficial for survival. Similarly, social play has a multifaceted role in promoting survival and fitness of animals. Play is a complex behavior that is greatly i...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000444015
更新日期:2016-01-01 00:00:00
abstract::In the presence of nerve growth factor (NGF) PC12 pheochromocytoma cells develop properties of sympathetic neurons and extend long microtubule-containing neurites. PC12 cell microtubule protein was isolated using an assembly and disassembly procedure, either directly from an unlabeled cell extract or by copolymerizati...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112330
更新日期:1983-01-01 00:00:00
abstract::Early research in the Vannucci laboratory prior to 1981 focused largely on brain energy metabolism in the developing rat. At that time, there was no experimental model to study the effects of perinatal hypoxia-ischemia in the rodent, despite the tremendous need to investigate the pathophysiology of perinatal asphyxial...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000085978
更新日期:2005-03-01 00:00:00
abstract::Rabbit central (CNS) and peripheral nervous system (PNS) myelin, as well as nonmyelinating pig oligodendrocytes in culture, were extracted at 0-4 degrees C with the nonionic detergent Triton X-114. The solubilized proteins were partitioned into the detergent-rich and detergent-depleted (aqueous) phases that form upon ...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111935
更新日期:1989-01-01 00:00:00
abstract::The neonatal brain appears to be selectively vulnerable to oxidative stress. Several potential mechanisms associated with altered reactive oxygen species metabolism would explain the increased susceptibility. They include increased accumulation of hydrogen peroxide with subsequent neurotoxicity. This enhanced neurotox...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000046143
更新日期:2001-01-01 00:00:00
abstract::Chick embryo retina neurons in culture extend neurites and form synapses. Seven different culture substrates were compared to determine which culture surface would produce the best neuronal survival and neurite extension. The order of survival of retina neurons during 7 days of culture is salt-precipitated collagen gr...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112705
更新日期:1982-01-01 00:00:00
abstract::Our previous studies of H218, a sphingosine 1-phosphate (S1P) receptor and a member of the G-protein-coupled receptor superfamily, suggest that it may participate in mammalian nervous system development. Thus, brain levels of H218 mRNA are higher during early neurogenesis than postnatally. In addition, embryonic H218 ...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000017452
更新日期:2000-01-01 00:00:00
abstract::In the era of therapeutic hypothermia, reliable preclinical studies are integral to successfully identify neuroprotective strategies to further improve outcomes of encephalopathy at term. We reviewed preclinical neuroprotection studies reported between January 2014 and June 2016 to assess the use of effective temperat...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000452859
更新日期:2017-01-01 00:00:00
abstract::The neurochemical effect of postnatal exposure to methadone (METH), undernutrition (UND), and methadone and undernutrition (METH-UND) on the whole brain and cerebellum were examined in 21- and 60-day-old rats. At 21 days, body weight reductions of UND and METH-UND rats exceeded that of the METH animals. However, METH ...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112698
更新日期:1982-01-01 00:00:00
abstract::Prenatal fever could result in brain function impairments in the offspring. The present study investigated the effect of interleukin-6 (IL-6)-induced maternal fever on the offspring and the involvement of connexin 36 in this process. Pregnant C57BL/6J mice were injected with IL-6 on gestational day 15. The levels of i...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000499735
更新日期:2019-01-01 00:00:00
abstract::The hippocampal formation is a multicomponent region of the medial temporal lobe preferentially involved in declarative and relational memory processing. Behavioral studies have suggested a protracted functional maturation of these structures in primates, and postnatal developmental abnormalities in the hippocampal fo...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000096222
更新日期:2007-01-01 00:00:00
abstract::Various abnormalities in frontal and striatal regions have been reported in children with prenatal alcohol and/or methamphetamine exposure. In a recent fMRI study, we observed a correlation between accuracy on a working-memory task and functional activation in the putamen in children with prenatal methamphetamine and ...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000336242
更新日期:2012-01-01 00:00:00
abstract::In this study, the proliferative activity of cultured chick neuroblasts exposed to high or low concentrations of fetal calf serum (FCS) was investigated. Different experimental evidences showed that the first 2-3 days of culture correspond to a period of neuronal proliferation in our culture conditions, whereas contam...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112344
更新日期:1983-01-01 00:00:00
abstract::Systemic creatine (Cr) supplementation increases brain phosphocreatine (PCr) and prevents hypoxic seizures in 15-day-old rabbits. Between 5 and 30 days of age during normal development, rabbit gray matter mitochondrial creatine kinase (Mi-CK) increases 400% while cytosolic CK (BB-CK) increases 60%. In white matter, bo...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000017473
更新日期:2000-09-01 00:00:00
abstract::In order to investigate the possible influence of norepinephrine (NE) on neuronal development, the effects of neonatal NE depletion on postnatally developing cell populations were characterized in (1) the normal mouse cerebellum, and (2) a cerebellar model system with delayed germinal cell development produced by neon...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112695
更新日期:1982-01-01 00:00:00
abstract::Adrenoleukodystrophy (ALD) is an X-linked recessive disorder that affects mainly the nervous system white matter and the adrenal cortex. It is associated with an abnormal accumulation of saturated very long chain fatty acids and can be diagnosed by demonstrating an excess of these substances in plasma or red cells. Ou...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000112170
更新日期:1991-01-01 00:00:00
abstract::In some cells, the development of voltage-gated channels requires synaptic input, while in others it does not. Here we investigate whether the sodium and potassium currents in the skeletal muscle of zebrafish sofa potato (sop(-/-)) mutants develop normally. Zebrafish sop(-/-) mutants do not express nicotinic acetylcho...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000207794
更新日期:2009-01-01 00:00:00
abstract::Cell polarity is one of the most basic properties of all normal cells and loss of polarity is a hallmark of cancer. While multiple proteins have been implicated in the maintenance of cell polarity, the functionally related neoplastic tumor suppressors Lethal giant larvae (Lgl), Scribble and Disks large comprise a uniq...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000090749
更新日期:2006-01-01 00:00:00
abstract::The lipids of white matter and peripheral nerve from mutant mice with known myelin deficiencies were analyzed by one- and two-dimensional high-performance thin-layer chromatography and quantitated by densitometry. In optic nerve, the mutants jp/Y, jpmsd/Y, qk/qk, shi/shi and shimld/shimld, which have severe central ne...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111961
更新日期:1988-01-01 00:00:00
abstract::Nitric oxide may serve as a retrograde messenger to refine or stabilize synapses in the developing nervous system. Whether this action is dependent upon glutamate and the N-methyl-D-aspartate receptor is not yet established. We have used the patch-cluster system in the intermediate gray layer (IGL) of the rat superior...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111215
更新日期:1997-01-01 00:00:00