Age and etiology as predictors of language outcome following hemispherectomy.

abstract：:We have previously shown that lipopolysaccharide (LPS) sensitizes the immature rat brain to subsequent hypoxic-ischemic (HI) injury; however, the underlying mechanisms remain unclear. In this study, we examined the role of glucose in the sensitizing effects of LPS and lipoteichoic acid (LTA) in combination with HI in ...

journal_title：Developmental neuroscience

authors： Eklind S,Arvidsson P,Hagberg H,Mallard C

更新日期：2004-01-01 00:00:00

abstract：:Cortex cerebri pieces from fetal donors were homologously and bilaterally grafted to the anterior eye chamber of adult albino rats. After intraocular maturation, presence of an external glial membrane, glial membranes surrounding blood vessels and cortical astrocytes was demonstrated using antisera raised against glia...

journal_title：Developmental neuroscience

authors： Björklund H,Dahl D

更新日期：1982-01-01 00:00:00

abstract：:In the presence of nerve growth factor (NGF) PC12 pheochromocytoma cells develop properties of sympathetic neurons and extend long microtubule-containing neurites. PC12 cell microtubule protein was isolated using an assembly and disassembly procedure, either directly from an unlabeled cell extract or by copolymerizati...

journal_title：Developmental neuroscience

authors： Richter-Landsberg C,Landreth GE,Shooter EM

更新日期：1983-01-01 00:00:00

abstract：:Three experimental approaches were used to examine the maturation of N-methyl-D-aspartate (NMDA) receptors in the neostriatum and compare their developmental profile to that of the non-NMDA receptors [alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and kainate (KA)]. The first, and least conventional ...

journal_title：Developmental neuroscience

authors： Colwell CS,Cepeda C,Crawford C,Levine MS

更新日期：1998-01-01 00:00:00

abstract：:Although multipotent progenitor cells capable of generating neurons, astrocytes and oligodendrocytes are present within the germinal zones of the brain throughout embryonic, postnatal and adult life, the different neural cell types are generated within discrete temporospatial developmental windows. This might suggest ...

journal_title：Developmental neuroscience

authors： Mehler MF,Mabie PC,Zhu G,Gokhan S,Kessler JA

更新日期：2000-01-01 00:00:00

abstract：:We have previously shown that a single intracranial injection of apotransferrin (aTf) in neonatal rats produces an accelerated mylinogenesis and increases the expression of certain myelin proteins such as myelin basic protein (MBP). In the present work, we studied the effects of aTf upon oligodendrocyte progenitor cel...

journal_title：Developmental neuroscience

authors： Paez PM,Marta CB,Moreno MB,Soto EF,Pasquini JM

更新日期：2002-01-01 00:00:00

abstract：:In adult rats, kainic acid-induced status epilepticus markedly reduces GluR2 (the alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid, AMPA subunit that limits Ca2+ permeability), receptor mRNA in the vulnerable CA3 and may contribute to delayed neurodegeneration. In rat pups resistant to kainate seizure-induced...

journal_title：Developmental neuroscience

authors： Friedman LK,Sperber EF,Moshé SL,Bennett MV,Zukin RS

更新日期：1997-01-01 00:00:00

abstract：:Neuroblastoma is a childhood cancer caused by the transformation of sympathoadrenal progenitors. By following the formation of tumors in homozygous TH-MYCN mice, an established mouse model of neuroblastoma, we were able to capture transformed cells prior to the formation of large, vascularized tumors in order to deter...

journal_title：Developmental neuroscience

authors： DeWitt J,Pappas A,Nishi R

更新日期：2014-01-01 00:00:00

abstract：:We have previously reported that a developmental axon-sparing striatal injury induced by hypoxia-ischemia results in a diminished adult number of substantia nigra (SN) tyrosine hydroxylase (TH)-positive neurons, in the absence of direct nigral injury. To examine the specific role of striatal injury, we made selective ...

journal_title：Developmental neuroscience

authors： Macaya A,Burke RE

更新日期：1992-01-01 00:00:00

abstract：:Neuroprotective cold-shock proteins (CSPs) are abundant in the normothermic neonatal rodent brain but decrease with advancing neurodevelopmental age and are low or absent in the adult brain. It has not been established if neurodevelopmental age alters the baseline expression of CSPs in the human brain. Here, we tested...

journal_title：Developmental neuroscience

authors： Jackson TC,Kotermanski SE,Kochanek PM

更新日期：2018-01-01 00:00:00

abstract：:There is an important unmet need to further improve the outcome of neonatal encephalopathy in term infants. Meta-analyses of large controlled trials now suggest that maternal magnesium sulfate (MgSO4) therapy is associated with a reduced risk of cerebral palsy and gross motor dysfunction after premature birth, but tha...

journal_title：Developmental neuroscience

authors： Galinsky R,Bennet L,Groenendaal F,Lear CA,Tan S,van Bel F,Juul SE,Robertson NJ,Mallard C,Gunn AJ

更新日期：2014-01-01 00:00:00

abstract：:The developing retina is characterized by 'retinal waves', spontaneous depolarizations that propagate through a developing network of interneurons and retinal ganglion cells. Although the circuitry underlying retinal waves is well characterized, the secreted factors that are critical for its normal development are not...

journal_title：Developmental neuroscience

authors： Colicos MA,Firth SI,Bosze J,Goldstein J,Feller MB

更新日期：2004-01-01 00:00:00

abstract：:The hippocampal formation is a multicomponent region of the medial temporal lobe preferentially involved in declarative and relational memory processing. Behavioral studies have suggested a protracted functional maturation of these structures in primates, and postnatal developmental abnormalities in the hippocampal fo...

journal_title：Developmental neuroscience

authors： Lavenex P,Banta Lavenex P,Amaral DG

更新日期：2007-01-01 00:00:00

abstract：:In the development of an integrated approach to study metabolic compartmentation and regulation in brain, we have emphasized the importance, versatility, and need to exploit the recent methodological advances in (1) NMR spectroscopy, (2) primary cultures of neurons and glial cells, and (3) subcellular fractionation (e...

journal_title：Developmental neuroscience

authors： Lai JC,Behar KL

更新日期：1993-01-01 00:00:00

abstract：:We have used whole-cell and single-channel recording techniques to investigate the electrophysiological properties of cultured ovine oligodendrocytes (OLGs). Our studies have led to the following conclusions. (1) Cultured mature OLGs express a variety of voltage-dependent K+ conductances including an outward current t...

journal_title：Developmental neuroscience

authors： Soliven B,Szuchet S,Arnason BG,Nelson DJ

更新日期：1989-01-01 00:00:00

abstract：:The postnatal development of the complexes of the electron transport chain in mitochondria isolated from rat brain synaptosomes was investigated. Synaptosomal brain mitochondria were isolated from rats aged 10-60 days, and the activities of mitochondrial complex I, complex II-III, complex IV and complex V were measure...

journal_title：Developmental neuroscience

authors： Almeida A,Brooks KJ,Sammut I,Keelan J,Davey GP,Clark JB,Bates TE

更新日期：1995-01-01 00:00:00

abstract：:The rate of glutaminase-dependent metabolism of glutamine in intact astrocytes was determined under conditions in which the extracellular concentration of glutamine was varied between 0.2 and 3.2 mM glutamine for control and dibutyryl cyclic AMP (dBcAMP)-treated cells. Glutamine metabolism by intact cells increased wi...

journal_title：Developmental neuroscience

authors： Zielke HR,Tildon JT,Zielke CL

更新日期：1996-01-01 00:00:00

abstract：:The spontaneously immortalized S16 Schwann cell line expresses higher levels of myelin-associated glycoprotein (MAG) and PO glycoprotein and their messenger RNAs when grown at high density than at low density [Sasagasako et al: J Neurochem 1996;66:1432-1439]. This up-regulation of myelin protein expression at high den...

journal_title：Developmental neuroscience

authors： Sasagasako N,Ohno M,Quarles RH

更新日期：1999-01-01 00:00:00

abstract：:The expression of voltage-gated potassium channels plays an important role in the acquisition of membrane excitability in neurons. We examined the expression pattern of genes in developing cerebellar granule neurons in vivo and in vitro. In situ hybridization of Kv3.1 mRNA demonstrated that the gene was expressed at h...

journal_title：Developmental neuroscience

authors： Shibata R,Wakazono Y,Nakahira K,Trimmer JS,Ikenaka K

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Neonatal hypoxic-ischemic (HI) encephalopathy occurs in 1-4 per 1,000 live term births and can cause devastating neurodevelopmental disabilities. Currently, therapeutic hypothermia (TH) is the only treatment with proven efficacy. Since TH is associated with decreased cerebral metabolism and cerebral blood fl...

journal_title：Developmental neuroscience

authors： Buckley EM,Patel SD,Miller BF,Franceschini MA,Vannucci SJ

更新日期：2015-01-01 00:00:00

abstract：:In the developing brain the majority of neurons migrate from their birthplace to their final destination. This active movement is essential for the formation of cortical layers and nuclei. The impairment of migration does not affect the viability of neurons but often results in abnormal differentiation. The proper mig...

journal_title：Developmental neuroscience

authors： Jiang Y,Kumada T,Cameron DB,Komuro H

更新日期：2008-01-01 00:00:00

abstract：:The current work tested the hypothesis that the zinc status of a cell influences its sensitivity to iron-induced oxidative stress. Human IMR-32 neuroblastoma cells were cultured for 24 h in nonchelated control media (5 microM zinc; 4.5 microM iron), or in media that was treated with DTPA to reduce its zinc content (ch...

journal_title：Developmental neuroscience

authors： Mackenzie GG,Keen CL,Oteiza PI

更新日期：2002-01-01 00:00:00

abstract：:Various abnormalities in frontal and striatal regions have been reported in children with prenatal alcohol and/or methamphetamine exposure. In a recent fMRI study, we observed a correlation between accuracy on a working-memory task and functional activation in the putamen in children with prenatal methamphetamine and ...

journal_title：Developmental neuroscience

authors： Roussotte FF,Rudie JD,Smith L,O'Connor MJ,Bookheimer SY,Narr KL,Sowell ER

更新日期：2012-01-01 00:00:00

abstract：:Dissociated cells of cerebral hemispheres from 8-day-old chick embryos were cultivated for 8 days in polylysine-coated Petri dishes. Changes of DNA, RNA, total proteins, putrescine, spermidine, spermine, free amino acids and enzymes involved in polyamine and GABA metabolism were studied throughout neuronal development...

journal_title：Developmental neuroscience

authors： Seiler N,Sarhan S,Roth-Schechter BF

更新日期：1981-01-01 00:00:00

abstract：:In vertebrate species, the neuropeptide oxytocin (OT) has been implicated in neural and behavioral development. Although several OT-like peptides have been characterized in invertebrate species, the ontogenesis of the OT-like system has not yet been described in these species. Thus, the aim of the present study was to...

journal_title：Developmental neuroscience

authors： Bardou I,Maubert E,Leprince J,Chichery R,Dallérac G,Vaudry H,Agin V

更新日期：2010-03-01 00:00:00

abstract：:Maternal inflammation has been linked to neurodevelopmental and neuropsychiatric disorders such as cerebral palsy, schizophrenia, and autism. We had previously shown that intrauterine inflammation resulted in a decrease in serotonin, one of the tryptophan metabolites, and a decrease in serotonin fibers in the sensory ...

journal_title：Developmental neuroscience

authors： Williams M,Zhang Z,Nance E,Drewes JL,Lesniak WG,Singh S,Chugani DC,Rangaramanujam K,Graham DR,Kannan S

更新日期：2017-01-01 00:00:00

abstract：:The long noncoding RNA MSNP1AS (moesin pseudogene 1, antisense) is a functional element that was previously associated with autism spectrum disorder (ASD) with genome-wide significance. Expression of MSNP1AS was increased 12-fold in the cerebral cortex of individuals with ASD and 22-fold in individuals with a genome-w...

journal_title：Developmental neuroscience

authors： DeWitt JJ,Hecht PM,Grepo N,Wilkinson B,Evgrafov OV,Morris KV,Knowles JA,Campbell DB

更新日期：2016-01-01 00:00:00

abstract：:Cortical dysplasia (CD) is now recognized as one of the major causes of pediatric focal neocortical epilepsy, and surgical procedures have been considered early in life. However, the mechanisms involved in seizure generation and intractability in these patients are still unknown. We analyzed with immunocytochemistry f...

journal_title：Developmental neuroscience

authors： Hilbig A,Babb TL,Najm I,Ying Z,Wyllie E,Bingaman W

更新日期：1999-11-01 00:00:00

abstract：:Although cortical malformations (CMs) are often associated with epilepsy, the underlying mechanisms are unknown. The reeler mouse is a model of CM with enhanced susceptibility to epileptiform activity, including the in vitro dentate gyrus, a region normally resistant to seizures. In this study, field potential recordi...

journal_title：Developmental neuroscience

authors： Patrylo PR,Willingham A

更新日期：2007-01-01 00:00:00

abstract：:Necrotizing enterocolitis (NEC) increases the risk of brain injury and impaired neurodevelopment. Rapid brain maturation prior to birth may explain why preterm brains are particularly vulnerable to serious infections. Using pigs as models, we hypothesized that preterm birth was associated with altered blood-cerebrospi...

journal_title：Developmental neuroscience

authors： Brunse A,Abbaspour A,Sangild PT

更新日期：2018-01-01 00:00:00