Abstract：
:Three experimental approaches were used to examine the maturation of N-methyl-D-aspartate (NMDA) receptors in the neostriatum and compare their developmental profile to that of the non-NMDA receptors [alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and kainate (KA)]. The first, and least conventional approach utilized infrared videomicroscopy to measure NMDA-induced swelling in single cells in a brain slice. The results demonstrated that NMDA receptors display an incremental pattern of postnatal development with no responses at postnatal day (PND) 3, weak responses at PND 7, the largest responses by PND 14 and slight decreases at PNDs 21 and 28. At PNDs 3 and 7, KA-induced cell swelling was proportionately greater than NMDA-induced cell swelling suggesting earlier maturation of this non-NMDA receptor subtype. The second approach used whole-cell patch clamp analysis to examine NMDA currents and compare their maturation to AMPA/KA-induced currents. Though the data are still preliminary, a very similar developmental pattern emerged. NMDA-induced currents were small and developed slowly after PND 7. In contrast, AMPA/KA-induced currents were larger and appeared to develop earlier. Finally, dizocilpine (MK-801) binding was measured in homogenates of neostriatal tissue. The ontogeny of binding resembled a step function with increases between PNDs 3 and 7 and PNDs 14 and 21. Binding peaked at PND 28 and then declined slightly in the adult (PND 60). The affinity of MK-801 for the receptor did not change during postnatal development. These findings demonstrate the pattern of functional development of glutamate receptors in the neostriatum. The NMDA receptor subtype displays minimal functional development until PND 14. In contrast, neostriatal AMPA/KA receptor function appears to precede NMDA receptor function.
journal_name
Dev Neuroscijournal_title
Developmental neuroscienceauthors
Colwell CS,Cepeda C,Crawford C,Levine MSdoi
10.1159/000017310subject
Has Abstractpub_date
1998-01-01 00:00:00pages
154-63issue
2-3eissn
0378-5866issn
1421-9859pii
dne20154journal_volume
20pub_type
杂志文章abstract：:The cerebromicrovasculature of immature mice ranging in age from 1-24 days after birth was studied by electron microscopy. A micromanipulator apparatus enabled us to facilitate direction of a needle cannula and injection into leg veins or hearts with horseradish peroxidase (HRP) or ferritin (anionic and cationic) trac...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000112242
更新日期：1986-01-01 00:00:00
abstract：:Cell polarity is one of the most basic properties of all normal cells and loss of polarity is a hallmark of cancer. While multiple proteins have been implicated in the maintenance of cell polarity, the functionally related neoplastic tumor suppressors Lethal giant larvae (Lgl), Scribble and Disks large comprise a uniq...
journal_title：Developmental neuroscience
pub_type： 杂志文章,评审
doi：10.1159/000090749
更新日期：2006-01-01 00:00:00
abstract：:Adult GM2 gangliosidosis is a rare autosomal recessive disease with widely varying neurological and psychiatric manifestations. It is caused by marked deficiency, but not total absence, of beta-hexosaminidase (Hex) A, due to a single base change in the alpha-subunit gene of Hex, resulting in a substitution of Ser for ...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000112200
更新日期：1991-01-01 00:00:00
abstract：:In cultured glial cells from chick embryonic brain, both influx and efflux of 42K+ and 22Na+ are dependent on the external Ca++ and concentration ([Ca++]0) between 2 and 0.1 mM although intracellular concentrations of K+ ([K+]i) and Na+ ([Na+]i) do not change. Only a reduction of [Ca++]0 below 0.1 mM results in both a...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000112664
更新日期：1982-01-01 00:00:00
abstract：:The neonatal brain appears to be selectively vulnerable to oxidative stress. Several potential mechanisms associated with altered reactive oxygen species metabolism would explain the increased susceptibility. They include increased accumulation of hydrogen peroxide with subsequent neurotoxicity. This enhanced neurotox...
journal_title：Developmental neuroscience
pub_type： 杂志文章,评审
doi：10.1159/000046143
更新日期：2001-01-01 00:00:00
abstract：:Maternal peptides from the hypothalamic-pituitary-adrenal (HPA) axis rise during human pregnancy. The effects of circulating maternal adrenocorticotropin (ACTH) and beta-endorphin (BE) on human fetal behavior was determined in 135 women during their 32nd week of gestation. Fetal behavior was measured by assessing hear...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000071467
更新日期：2003-01-01 00:00:00
abstract：:Neural stem cells are attracting enormous attention in regenerative medicine due to their ability to self-renew and differentiate into the cell lineages that constitute the central nervous system. However, little is known about the mechanism underlying the regulation of their redox environment, which is essential for ...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000493009
更新日期：2018-01-01 00:00:00
abstract：:Apoptosis contributes greatly to the morphological and biochemical features of cell death after neonatal cerebral hypoxia-ischemia (HI), making this mode of cell death a promising therapeutic target. We previously showed that 10 mg/kg of the caspase inhibitor Q-VD-OPh at the onset of and immediately after HI on postna...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000357939
更新日期：2014-01-01 00:00:00
abstract：:To define the effects of neurotrophins on oligodendrocytes, we monitored NGF, BDNF and NT-3 actions on basal forebrain (BF) and cortical populations. NGF, BDNF and NT-3 applied to BF oligodendrocytes elicited increases in expression of myelin basic protein (MBP) and enhanced the numbers of MBP+ cells, without affectin...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000072261
更新日期：2003-03-01 00:00:00
abstract：:Neuroblastoma is a childhood cancer caused by the transformation of sympathoadrenal progenitors. By following the formation of tumors in homozygous TH-MYCN mice, an established mouse model of neuroblastoma, we were able to capture transformed cells prior to the formation of large, vascularized tumors in order to deter...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000365281
更新日期：2014-01-01 00:00:00
abstract：:The auditory system of the cricket has the unusual ability to respond to deafferentation by compensatory growth and synapse formation. Auditory interneurons such as ascending neuron 2 (AN-2) in the cricket Gryllus bimaculatus possess a dendritic arbor that normally grows up to, but not over, the midline of the prothor...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000322887
更新日期：2011-01-01 00:00:00
abstract：:The distribution of the noradrenergic system within the rat cerebellar cortex following low-level X-irradiation was studied using tyrosine hydroxylase immunocytochemistry. X-Irradiation treatments consisted of 1, 3, or 5 successive daily dose beginning on postnatal day 1. When studied 24 h after the last exposure, a d...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000112092
更新日期：1994-01-01 00:00:00
abstract：:In the era of therapeutic hypothermia, reliable preclinical studies are integral to successfully identify neuroprotective strategies to further improve outcomes of encephalopathy at term. We reviewed preclinical neuroprotection studies reported between January 2014 and June 2016 to assess the use of effective temperat...
journal_title：Developmental neuroscience
pub_type： 杂志文章,评审
doi：10.1159/000452859
更新日期：2017-01-01 00:00:00
abstract：:Traumatic brain injury (TBI) is the leading cause of death and disability in children. Evidence-based guidelines for the management of this population are available; however, the data highlight significant deficiencies with few treatment standards or guidelines. Considering the limited availability of resources, it is...
journal_title：Developmental neuroscience
pub_type： 杂志文章,评审
doi：10.1159/000094153
更新日期：2006-01-01 00:00:00
abstract：:The M50 and M100 auditory evoked responses reflect early auditory processes in the primary/secondary auditory cortex. Although previous M50 and M100 studies have been conducted on individuals with autism spectrum disorder (ASD) and indicate disruption of encoding simple sensory information, analogous investigations of...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000504960
更新日期：2019-01-01 00:00:00
abstract：:The effect of undernutrition on the activity of glutamate decarboxylase (GAD) and choline acetyltransferase (ChAc) (markers for the GABA-ergic and the cholinergic transmitter system, respectively) was studied in various parts of the rat brain at the age of 10, 15 and 21 days, and at day 54 following 33 days of rehabil...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000112551
更新日期：1978-01-01 00:00:00
abstract：:Maternal infection during pregnancy increases the risk of neurobehavioral problems in offspring. Evidence from rodent models indicates that the maternal immune response to infection can alter fetal brain development, particularly in the hippocampus. However, information on the effects of maternal viral infection on fe...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000486850
更新日期：2018-01-01 00:00:00
abstract：:Although cortical malformations (CMs) are often associated with epilepsy, the underlying mechanisms are unknown. The reeler mouse is a model of CM with enhanced susceptibility to epileptiform activity, including the in vitro dentate gyrus, a region normally resistant to seizures. In this study, field potential recordi...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000096212
更新日期：2007-01-01 00:00:00
abstract：:Excitotoxicity plays a key role during insults to the developing brain such as neonatal encephalopathy, stroke, and encephalopathy of prematurity. Such insults affect many thousands of infants each year. Excitotoxicity causes frank lesions due to cell death and gliosis and disturbs normal developmental process, leadin...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000464131
更新日期：2017-01-01 00:00:00
abstract：:Chick embryo retina neurons in culture extend neurites and form synapses. Seven different culture substrates were compared to determine which culture surface would produce the best neuronal survival and neurite extension. The order of survival of retina neurons during 7 days of culture is salt-precipitated collagen gr...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000112705
更新日期：1982-01-01 00:00:00
abstract：:The myelin-associated glycoprotein (MAG) in primary cultures of oligodendrocytes is subject to phosphorylation in the absence of neurons. The positive response of this phosphorylation to vanadate suggests that one of the modified sites in MAG is phosphotyrosine. We found that phosphorylation was enhanced by brief trea...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000112192
更新日期：1991-01-01 00:00:00
abstract：:When cells from the cerebellum of late-gestation rats were grown at low density (50-100 cells/mm2) in a three-dimensional culture system, they rapidly expressed morphological and electrophysiological properties of neurons. Growth and differentiation of the population of solitary neurons as a whole was statistically as...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000111645
更新日期：1992-01-01 00:00:00
abstract：:Neonatal stroke leads to mortality and severe morbidity, but there is no effective treatment currently available. Erythropoietin (EPO) has been shown to promote cytoprotection and neurogenesis and decrease subventricular zone morphologic changes following brain injury. The long-term cellular response to EPO has not be...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000105473
更新日期：2007-01-01 00:00:00
abstract：:Neurotransmitters play important roles in neurogenesis; in particular, acetylcholine and serotonin may regulate neurite elongation. Acetylcholine may also activate transcription factors such as early growth response protein 1 (EGR-1), which plays a role in neurite extension. N18TG2 neuroblastoma cells (which do not pr...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000354423
更新日期：2013-01-01 00:00:00
abstract：:Neuroprotective cold-shock proteins (CSPs) are abundant in the normothermic neonatal rodent brain but decrease with advancing neurodevelopmental age and are low or absent in the adult brain. It has not been established if neurodevelopmental age alters the baseline expression of CSPs in the human brain. Here, we tested...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000493637
更新日期：2018-01-01 00:00:00
abstract：:We studied the developmental changes of soluble and membrane-bound protein kinases (EC 2.7.1.37) in rat brain and found that the elution profiles from a DEAE-cellulose column by NaCl of adenosine-3':5'-monophosphate (cyclic AMP) dependent protein kinase from cytosol were not significantly different in newborn (0.19 M ...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000112450
更新日期：1979-01-01 00:00:00
abstract：BACKGROUND:Therapeutic hypothermia provides incomplete neuroprotection for neonatal hypoxic-ischemic encephalopathy (HIE). We examined whether hemodynamic goals that support autoregulation are associated with decreased brain injury and whether these relationships are affected by birth asphyxia or vary by anatomic regio...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000452833
更新日期：2017-01-01 00:00:00
abstract：:Early research in the Vannucci laboratory prior to 1981 focused largely on brain energy metabolism in the developing rat. At that time, there was no experimental model to study the effects of perinatal hypoxia-ischemia in the rodent, despite the tremendous need to investigate the pathophysiology of perinatal asphyxial...
journal_title：Developmental neuroscience
pub_type： 杂志文章,评审
doi：10.1159/000085978
更新日期：2005-03-01 00:00:00
abstract：:There is an important unmet need to further improve the outcome of neonatal encephalopathy in term infants. Meta-analyses of large controlled trials now suggest that maternal magnesium sulfate (MgSO4) therapy is associated with a reduced risk of cerebral palsy and gross motor dysfunction after premature birth, but tha...
journal_title：Developmental neuroscience
pub_type： 杂志文章,评审
doi：10.1159/000362206
更新日期：2014-01-01 00:00:00
abstract：:Creatine kinase (CK) isoenzymes, with emphasis on the mitochondrial CK isoenzymes, were characterized and localized in chicken cerebellum. Chicken cerebellum extracts analyzed by two-dimensional gels, using antipeptide antibodies specific for sarcomeric muscle-type mitochondrial CK (Mib-CK) and revealed the presence o...
journal_title：Developmental neuroscience
pub_type： 杂志文章,评审
doi：10.1159/000111452
更新日期：1996-01-01 00:00:00
