Abstract:
:We studied the developmental changes of soluble and membrane-bound protein kinases (EC 2.7.1.37) in rat brain and found that the elution profiles from a DEAE-cellulose column by NaCl of adenosine-3':5'-monophosphate (cyclic AMP) dependent protein kinase from cytosol were not significantly different in newborn (0.19 M NaCl) vs. mature (0.21 M NaCl). In addition, there was little change in Kd for cyclic AMP binding of newborn and mature soluble enzyme. In contrast, using endogenous protein as the phosphate acceptor, cyclic AMP dependent and calcium-dependent protein kinases from brain synaptic membranes of mature rats were significantly higher than that of newborn rats.
journal_name
Dev Neuroscijournal_title
Developmental neuroscienceauthors
Kinnier WJ,Chikvaidze V,Hollenbeck RA,Chuang DM,Costa Edoi
10.1159/000112450subject
Has Abstractpub_date
1979-01-01 00:00:00pages
154-9issue
4eissn
0378-5866issn
1421-9859journal_volume
2pub_type
杂志文章abstract::Dissociated brain cell cultures are a useful model for investigating development and differentiation of oligodendrocytes in vitro. The current studies compare the developmental patterns of expression for oligodendrocyte lineage/myelin markers in both primary and secondary oligodendrocyte cultures derived from mouse an...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111276
更新日期:1995-01-01 00:00:00
abstract::We have shown that the developmentally regulated appearance of the two myelin-associated glycoprotein (MAG) polypeptides in normal mouse brain myelin does not reflect the developmental pattern of differential splicing of primary gene transcripts as determined earlier by RNase protection assays. Contrary to expectation...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111857
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Neonatal hypoxic-ischemic (HI) encephalopathy occurs in 1-4 per 1,000 live term births and can cause devastating neurodevelopmental disabilities. Currently, therapeutic hypothermia (TH) is the only treatment with proven efficacy. Since TH is associated with decreased cerebral metabolism and cerebral blood fl...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000381704
更新日期:2015-01-01 00:00:00
abstract::The Notch signaling pathway is important at several stages of retinal development including the differentiation of retinal ganglion cells and Muller glia. The downstream effectors of Notch signaling, Hes1 and Hes5, have been shown to be critical in the retina as well. While Notch activity directly regulates Hes1 and H...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000090759
更新日期:2006-01-01 00:00:00
abstract::The developing retina is characterized by 'retinal waves', spontaneous depolarizations that propagate through a developing network of interneurons and retinal ganglion cells. Although the circuitry underlying retinal waves is well characterized, the secreted factors that are critical for its normal development are not...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000082283
更新日期:2004-01-01 00:00:00
abstract::Evidence from retroviral marking techniques and immortalized cell lines indicates that multipotential stem cells exist in many areas of the developing central nervous system. However, the factors that influence the commitment of these stem cells into distinct neuronal or glial lineages are not known. We have created a...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111301
更新日期:1995-01-01 00:00:00
abstract::Astrocytes in primary cultures constitute an exceedingly useful preparation for studies of astroglial development and function. These cells, however, demonstrate a pronounced plasticity in their reactions to culturing conditions. Thus, species and spatiotemporal region of CNS chosen for source of cells, dissociation p...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000112295
更新日期:1985-01-01 00:00:00
abstract::NeuroD is a basic helix-loop-helix (bHLH) transcription factor cloned from a two hybrid screen designed to search for new bHLH proteins. In our previous studies, we showed that NeuroD could convert Xenopus ectoderm into fully differentiated neurons and that it could prematurely differentiate neural precursor cells in ...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000111182
更新日期:1997-01-01 00:00:00
abstract::This study analyzed the role of dopamine D1 and D2 receptors in methylphenidate (MPH) conditioned place preference (CPP) in adolescent male and female rats, in addition to the role of these receptors in the effects of MPH on brain-derived neurotrophic factor (BDNF) in the dorsal striatum and nucleus accumbens. Using a...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000360636
更新日期:2014-01-01 00:00:00
abstract::The development of the chick bulbar cardiac ganglia has been studied ultrastructurally from the 3rd day of incubation to hatching. For descriptive purposes, their development has been divided into three phases. The first phase includes migration and aggregation of undifferentiated neuroblasts, stages 21-26 (day 3.5-5)...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112390
更新日期:1980-01-01 00:00:00
abstract::In vertebrate species, the neuropeptide oxytocin (OT) has been implicated in neural and behavioral development. Although several OT-like peptides have been characterized in invertebrate species, the ontogenesis of the OT-like system has not yet been described in these species. Thus, the aim of the present study was to...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000235942
更新日期:2010-03-01 00:00:00
abstract::L-Ornithine decarboxylase (ODC), the rate-limiting enzyme of polyamine biosynthesis and thus a unique marker of the proliferation and maturation processes, has been localized by means of immunohistochemistry in the human central nervous system. The enzyme protein has not only been found in the developing nervous syste...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111320
更新日期:1993-01-01 00:00:00
abstract::Previous studies have demonstrated that exposure to ethanol during development delays the rate at which axons in certain central nervous system tracts acquire myelin. This delay appears to be related to an alteration in oligodendrocyte function and not to an aberrancy in axon size or number. The present study was desi...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112154
更新日期:1991-01-01 00:00:00
abstract::Adrenoleukodystrophy (ALD) is an X-linked recessive disorder that affects mainly the nervous system white matter and the adrenal cortex. It is associated with an abnormal accumulation of saturated very long chain fatty acids and can be diagnosed by demonstrating an excess of these substances in plasma or red cells. Ou...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000112170
更新日期:1991-01-01 00:00:00
abstract::Parallel developmental studies of central nervous system myelin proteins and morphology (postnatal days 15-118; P15-118) confirm qualitative similarities but substantial quantitative differences between homozygous mld mice with Billings-Gagliardi and Wolf's 'USA' versus Matthieu's 'Swiss' genetic backgrounds. The USA ...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112145
更新日期:1991-01-01 00:00:00
abstract::Nitric oxide may serve as a retrograde messenger to refine or stabilize synapses in the developing nervous system. Whether this action is dependent upon glutamate and the N-methyl-D-aspartate receptor is not yet established. We have used the patch-cluster system in the intermediate gray layer (IGL) of the rat superior...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111215
更新日期:1997-01-01 00:00:00
abstract::Hypoxic-ischemic brain injury is a leading cause of neurodevelopmental morbidities in preterm and full-term infants. Blood-brain barrier dysfunction represents an important component of perinatal hypoxic-ischemic brain injury. The extracellular matrix (ECM) is a vital component of the blood-brain barrier. Matrix metal...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000489700
更新日期:2018-01-01 00:00:00
abstract::The medial frontal cortex (MFC) is involved in the temporal organization of behaviour. It receives timing information from the master circadian clock in the suprachiasmatic nucleus (SCN), and exhibits daily oscillations in gene expression itself. In this study, we evaluate various properties of circadian rhythms of lo...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000232559
更新日期:2009-01-01 00:00:00
abstract::The cytoskeleton of a newly isolated mouse embryo brain-derived cell line and of dissected mesencephalon-rhombencephalon samples of the 10- to 11-day-old mouse embryo, constituted of a ventricular zone only, has been examined by immunocytochemistry, electrophoretic separation and Western blotting techniques. In accord...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111612
更新日期:1987-01-01 00:00:00
abstract::Preterm birth is an important cause of perinatal brain injury (PBI). Neurological injury in extremely preterm infants often begins in utero with chorioamnionitis (CHORIO) or inflammation/infection of the placenta and concomitant placental insufficiency. Studies in humans have shown dysregulated inflammatory signaling ...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000497273
更新日期:2019-03-28 00:00:00
abstract::Cerebral metabolism is known to be highly dependent upon glucose utilisation. In the neonate, severe hypoglycaemia is now recognized to be associated with subsequent adverse neurodevelopment and in extremis glial and neuronal cell death. However, the level at which hypoglycaemia becomes clinically important is not wel...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000112124
更新日期:1994-01-01 00:00:00
abstract::It has been demonstrated that postweaning social isolation alters dendritic development in the medial prefrontal cortex (mPFC) of the rat. In addition, (-)-deprenyl, a monoamine oxidase B (MAO-B) inhibitor, promotes dendritic growth in prefrontocortical pyramidal cells. This study examined whether prefrontocortical de...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000096413
更新日期:2007-01-01 00:00:00
abstract::There is an important unmet need to further improve the outcome of neonatal encephalopathy in term infants. Meta-analyses of large controlled trials now suggest that maternal magnesium sulfate (MgSO4) therapy is associated with a reduced risk of cerebral palsy and gross motor dysfunction after premature birth, but tha...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000362206
更新日期:2014-01-01 00:00:00
abstract::The rate of glutaminase-dependent metabolism of glutamine in intact astrocytes was determined under conditions in which the extracellular concentration of glutamine was varied between 0.2 and 3.2 mM glutamine for control and dibutyryl cyclic AMP (dBcAMP)-treated cells. Glutamine metabolism by intact cells increased wi...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111410
更新日期:1996-01-01 00:00:00
abstract::In order to investigate the possible influence of norepinephrine (NE) on neuronal development, the effects of neonatal NE depletion on postnatally developing cell populations were characterized in (1) the normal mouse cerebellum, and (2) a cerebellar model system with delayed germinal cell development produced by neon...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112695
更新日期:1982-01-01 00:00:00
abstract::A glia-derived neurite-promoting factor has been purified from medium conditioned by C6 rat glioma cells. It induces neurite outgrowth in cultured mouse neuroblastoma cells and inhibits granule cell migration in explants of mouse cerebellum. This factor is a potent serine protease inhibitor which has recently been sho...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111951
更新日期:1988-01-01 00:00:00
abstract::The metabolism of [1-13C]D-glucose by astrocytes, neurons and mixed astroglial/neuronal cultures derived from the striatum of fetal rats was studied using NMR. Metabolic activity was studied in resting and depolarized cells (55 mM K+), with dibutyryl cyclic-AMP added to the medium to promote cell differentiation, and ...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111346
更新日期:1993-01-01 00:00:00
abstract::The L-type calcium channel activator +/-Bay K 8644 has recently been shown to provoke self-injurious biting in young mice. Since the serotonergic systems have been implicated in the expression of self-injurious behavior in both humans and animals, the present studies tested whether drugs influencing serotonin systems ...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000066747
更新日期:2002-01-01 00:00:00
abstract::Three experimental approaches were used to examine the maturation of N-methyl-D-aspartate (NMDA) receptors in the neostriatum and compare their developmental profile to that of the non-NMDA receptors [alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and kainate (KA)]. The first, and least conventional ...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000017310
更新日期:1998-01-01 00:00:00
abstract::Neurite outgrowth is dependent on the presence in neurites of assembled microtubules which consist of polymerized tubulin to which microtubule-associated proteins (MAPs) are bound. This study adds to previous evidence of the similarity between the high molecular weight MAPs, MAP1X, MAP1B and MAP5, and explains the dif...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111318
更新日期:1993-01-01 00:00:00