Abstract：
:There is an important unmet need to further improve the outcome of neonatal encephalopathy in term infants. Meta-analyses of large controlled trials now suggest that maternal magnesium sulfate (MgSO4) therapy is associated with a reduced risk of cerebral palsy and gross motor dysfunction after premature birth, but that it has no effect on death or disability. Because of this inconsistency, it remains controversial whether MgSO4 is clinically neuroprotective and, thus, it is unclear whether it would be appropriate to test MgSO4 for treatment of encephalopathy in term infants. We therefore systematically reviewed the preclinical evidence for neuroprotection with MgSO4 before or after hypoxic-ischemic encephalopathy (HIE) in term-equivalent perinatal and adult animals. The outcomes were highly inconsistent between studies. Although there were differences in dose and timing of administration, there was evidence that beneficial effects of MgSO4 were associated with confounding mild hypothermia and, strikingly, the studies that included rigorous maintenance of environmental temperature or body temperature consistently suggested a lack of effect. On balance, these preclinical studies suggest that peripherally administered MgSO4 is unlikely to be neuroprotective. Rigorous testing in translational animal models of perinatal HIE is needed before MgSO4 should be considered in clinical trials for encephalopathy in term infants.
journal_name
Dev Neuroscijournal_title
Developmental neuroscienceauthors
Galinsky R,Bennet L,Groenendaal F,Lear CA,Tan S,van Bel F,Juul SE,Robertson NJ,Mallard C,Gunn AJdoi
10.1159/000362206subject
Has Abstractpub_date
2014-01-01 00:00:00pages
73-82issue
2eissn
0378-5866issn
1421-9859pii
000362206journal_volume
36pub_type
杂志文章,评审abstract：:We studied the developmental changes of soluble and membrane-bound protein kinases (EC 2.7.1.37) in rat brain and found that the elution profiles from a DEAE-cellulose column by NaCl of adenosine-3':5'-monophosphate (cyclic AMP) dependent protein kinase from cytosol were not significantly different in newborn (0.19 M ...
journal_title：Developmental neuroscience
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abstract：:This study analyzed the role of dopamine D1 and D2 receptors in methylphenidate (MPH) conditioned place preference (CPP) in adolescent male and female rats, in addition to the role of these receptors in the effects of MPH on brain-derived neurotrophic factor (BDNF) in the dorsal striatum and nucleus accumbens. Using a...
journal_title：Developmental neuroscience
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journal_title：Developmental neuroscience
pub_type： 杂志文章,评审
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abstract：:The neonatal rat model of unilateral cerebral hypoxia-ischemia (HI) is commonly used to test the efficacy of therapeutic strategies for prevention or treatment of stroke in the immature brain. Traditionally neuroprotection has been defined as reduction in tissue injury; there is growing interest in complementary funct...
journal_title：Developmental neuroscience
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abstract：:In order to investigate the possible influence of norepinephrine (NE) on neuronal development, the effects of neonatal NE depletion on postnatally developing cell populations were characterized in (1) the normal mouse cerebellum, and (2) a cerebellar model system with delayed germinal cell development produced by neon...
journal_title：Developmental neuroscience
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更新日期：2004-01-01 00:00:00
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journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000112777
更新日期：1981-01-01 00:00:00
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journal_title：Developmental neuroscience
pub_type： 杂志文章
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更新日期：2006-01-01 00:00:00
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journal_title：Developmental neuroscience
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更新日期：2017-01-01 00:00:00
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journal_title：Developmental neuroscience
pub_type： 杂志文章
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更新日期：2004-01-01 00:00:00
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journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000112383
更新日期：1980-01-01 00:00:00
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journal_title：Developmental neuroscience
pub_type： 杂志文章,评审
doi：10.1159/000112346
更新日期：1983-01-01 00:00:00
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journal_title：Developmental neuroscience
pub_type： 杂志文章
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更新日期：2005-01-01 00:00:00
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journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000343257
更新日期：2012-01-01 00:00:00
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journal_title：Developmental neuroscience
pub_type： 杂志文章,评审
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更新日期：1994-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2006-01-01 00:00:00
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journal_title：Developmental neuroscience
pub_type： 杂志文章
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更新日期：1997-01-01 00:00:00
abstract：:There is pressing need to employ new advances in structural MR brain imaging to better diagnose brain damage in newborn infants. Timely application of such technology will enable improved therapeutic interventions. Diffusion-weighted sequences are a sensitive marker of very early neuronal injury, the spatial pattern o...
journal_title：Developmental neuroscience
pub_type： 杂志文章
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更新日期：2005-03-01 00:00:00
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journal_title：Developmental neuroscience
pub_type： 杂志文章
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更新日期：2015-01-01 00:00:00
abstract：:A leading hypothesis of the cause of neuronal death in Huntington's disease (HD) is excitotoxicity, in which subpopulations of striatal neurons are hypersensitive to glutamate release due to changes in postsynaptic N-methyl-D-aspartate receptors (NMDARs). In the present study we used RT-PCR methods on single cells and...
journal_title：Developmental neuroscience
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更新日期：2006-01-01 00:00:00
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journal_title：Developmental neuroscience
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更新日期：1989-01-01 00:00:00
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journal_title：Developmental neuroscience
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更新日期：1998-01-01 00:00:00
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journal_title：Developmental neuroscience
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更新日期：1988-01-01 00:00:00
