A Dopamine Hypothesis of Autism Spectrum Disorder.

abstract：:It has been hypothesized that changes in striatal-mediated dopamine modulation during adolescence may increase the risk for initiating substance abuse as a result of its fundamental role in arbitrating reward sensitivity and motivation during learning and decision making. However, substance abuse during adolescence ma...

journal_title：Developmental neuroscience

authors： Churchwell JC,Carey PD,Ferrett HL,Stein DJ,Yurgelun-Todd DA

更新日期：2012-01-01 00:00:00

abstract：:Neuronal heterotopia is a malformation of cortical development that is closely associated with epilepsy in humans. Despite emerging interest in the structure and function of the heterotopic cortex, little is known about the membrane properties and synaptic connections of these displaced neurons. We used whole-cell pat...

journal_title：Developmental neuroscience

authors： Smith BN,Dudek FE,Roper SN

更新日期：1999-11-01 00:00:00

abstract：:Oligodendrocyte precursor cells (OPCs) originate in multiple restricted regions of the developing central nervous system (CNS). Here, we focus on morphological changes of oligodendrocyte lineage cells and their cellular dynamics including cell motility and proliferation. Morphological studies with molecular markers fo...

journal_title：Developmental neuroscience

authors： Ono K,Kagawa T,Tsumori T,Yokota S,Yasui Y

更新日期：2001-01-01 00:00:00

abstract：:Uncertainty reigns over whether or not glutamate uptake in astrocytes leads to strong stimulation of glucose utilization, measured as accumulation of radioactive deoxyglucose-6-phosphate. This is an important issue, not only because glutamate is the major excitatory transmitter, but also because it has been postulated...

journal_title：Developmental neuroscience

authors： Hertz L,Swanson RA,Newman GC,Marrif H,Juurlink BH,Peng L

更新日期：1998-01-01 00:00:00

abstract：:The cell line MN9D, a fusion of embryonic ventral mesencephalic and neuroblastoma cells, is extensively used as a model of dopamine (DA) neurons because it expresses tyrosine hydroxylase and synthesizes and releases DA. These cells are also used to test mechanisms and potential therapeutics relevant to the loss of DA ...

journal_title：Developmental neuroscience

authors： Rick CE,Ebert A,Virag T,Bohn MC,Surmeier DJ

更新日期：2006-01-01 00:00:00

abstract：:We have used whole-cell and single-channel recording techniques to investigate the electrophysiological properties of cultured ovine oligodendrocytes (OLGs). Our studies have led to the following conclusions. (1) Cultured mature OLGs express a variety of voltage-dependent K+ conductances including an outward current t...

journal_title：Developmental neuroscience

authors： Soliven B,Szuchet S,Arnason BG,Nelson DJ

更新日期：1989-01-01 00:00:00

abstract：:Cell polarity is one of the most basic properties of all normal cells and loss of polarity is a hallmark of cancer. While multiple proteins have been implicated in the maintenance of cell polarity, the functionally related neoplastic tumor suppressors Lethal giant larvae (Lgl), Scribble and Disks large comprise a uniq...

journal_title：Developmental neuroscience

authors： Vasioukhin V

更新日期：2006-01-01 00:00:00

abstract：:Birth asphyxia can result in sensory impairment, learning and memory deficits without gross brain injury and severe motor deficits. We developed a model of birth asphyxia resulting in mild neurological injury and cognitive impairment using a long-gestation species with precocial fetal development. Spiny mice (Acomys c...

journal_title：Developmental neuroscience

authors： Hutton LC,Ratnayake U,Shields A,Walker DW

更新日期：2009-01-01 00:00:00

abstract：:This study analyzed the role of dopamine D1 and D2 receptors in methylphenidate (MPH) conditioned place preference (CPP) in adolescent male and female rats, in addition to the role of these receptors in the effects of MPH on brain-derived neurotrophic factor (BDNF) in the dorsal striatum and nucleus accumbens. Using a...

journal_title：Developmental neuroscience

authors： Cummins ED,Griffin SB,Duty CM,Peterson DJ,Burgess KC,Brown RW

更新日期：2014-01-01 00:00:00

abstract：:The long noncoding RNA MSNP1AS (moesin pseudogene 1, antisense) is a functional element that was previously associated with autism spectrum disorder (ASD) with genome-wide significance. Expression of MSNP1AS was increased 12-fold in the cerebral cortex of individuals with ASD and 22-fold in individuals with a genome-w...

journal_title：Developmental neuroscience

authors： DeWitt JJ,Hecht PM,Grepo N,Wilkinson B,Evgrafov OV,Morris KV,Knowles JA,Campbell DB

更新日期：2016-01-01 00:00:00

abstract：:Ethanol inhibition of L1-mediated cell adhesion may contribute to the spectrum of neurological, behavioral and morphological abnormalities associated with prenatal ethanol exposure. We showed previously that the neuroprotective peptides NAPVSIPQ (NAP) and SALLRSIPA (SAL) antagonize ethanol inhibition of L1 adhesion an...

journal_title：Developmental neuroscience

authors： Chen SY,Charness ME,Wilkemeyer MF,Sulik KK

更新日期：2005-01-01 00:00:00

abstract：:A leading hypothesis of the cause of neuronal death in Huntington's disease (HD) is excitotoxicity, in which subpopulations of striatal neurons are hypersensitive to glutamate release due to changes in postsynaptic N-methyl-D-aspartate receptors (NMDARs). In the present study we used RT-PCR methods on single cells and...

journal_title：Developmental neuroscience

authors： Ali NJ,Levine MS

更新日期：2006-01-01 00:00:00

abstract：:The spontaneously immortalized S16 Schwann cell line expresses higher levels of myelin-associated glycoprotein (MAG) and PO glycoprotein and their messenger RNAs when grown at high density than at low density [Sasagasako et al: J Neurochem 1996;66:1432-1439]. This up-regulation of myelin protein expression at high den...

journal_title：Developmental neuroscience

authors： Sasagasako N,Ohno M,Quarles RH

更新日期：1999-01-01 00:00:00

abstract：:We have previously shown that lipopolysaccharide (LPS) sensitizes the immature rat brain to subsequent hypoxic-ischemic (HI) injury; however, the underlying mechanisms remain unclear. In this study, we examined the role of glucose in the sensitizing effects of LPS and lipoteichoic acid (LTA) in combination with HI in ...

journal_title：Developmental neuroscience

authors： Eklind S,Arvidsson P,Hagberg H,Mallard C

更新日期：2004-01-01 00:00:00

abstract：:Using Western blot and immunocytochemistry to detect protein, and in situ hybridization and Northern blot to detect RNA, we studied the expression of Na,K-ATPase subunit isoforms in cultured astrocytes and oligodendrocytes in vitro, and in glial cells in the brain. We found that astrocytes in culture express alpha 1 a...

journal_title：Developmental neuroscience

authors： Fink D,Knapp PE,Mata M

更新日期：1996-01-01 00:00:00

abstract：:In vertebrate species, the neuropeptide oxytocin (OT) has been implicated in neural and behavioral development. Although several OT-like peptides have been characterized in invertebrate species, the ontogenesis of the OT-like system has not yet been described in these species. Thus, the aim of the present study was to...

journal_title：Developmental neuroscience

authors： Bardou I,Maubert E,Leprince J,Chichery R,Dallérac G,Vaudry H,Agin V

更新日期：2010-03-01 00:00:00

abstract：:Apoptosis is a controlled form of cell death that participates in the demise of neuronal cells during development, neurodegenerative disorders and exposure to neurotoxic agents. In recent years, the mitochondria have emerged as being pivotal in controlling apoptosis. They house a number of apoptogenic molecules that a...

journal_title：Developmental neuroscience

authors： Gorman AM,Ceccatelli S,Orrenius S

更新日期：2000-09-01 00:00:00

abstract：:Metabolism of glutamate and glutamine in cultured mouse cerebral cortical astrocytes has been investigated using either radioactively labelled (14C) amino acids or 13C-labelled amino acids combined with NMR spectroscopy of cell extracts and lyophilyzed incubation media. Using [U-13C]glutamate it has been shown that in...

journal_title：Developmental neuroscience

authors： Schousboe A,Westergaard N,Sonnewald U,Petersen SB,Huang R,Peng L,Hertz L

更新日期：1993-01-01 00:00:00

abstract：:Nitric oxide may serve as a retrograde messenger to refine or stabilize synapses in the developing nervous system. Whether this action is dependent upon glutamate and the N-methyl-D-aspartate receptor is not yet established. We have used the patch-cluster system in the intermediate gray layer (IGL) of the rat superior...

journal_title：Developmental neuroscience

authors： Mize RR,Scheiner CA,Salvatore MF,Cork RJ

更新日期：1997-01-01 00:00:00

abstract：:The postnatal development of the complexes of the electron transport chain in mitochondria isolated from rat brain synaptosomes was investigated. Synaptosomal brain mitochondria were isolated from rats aged 10-60 days, and the activities of mitochondrial complex I, complex II-III, complex IV and complex V were measure...

journal_title：Developmental neuroscience

authors： Almeida A,Brooks KJ,Sammut I,Keelan J,Davey GP,Clark JB,Bates TE

更新日期：1995-01-01 00:00:00

abstract：:Prenatal fever could result in brain function impairments in the offspring. The present study investigated the effect of interleukin-6 (IL-6)-induced maternal fever on the offspring and the involvement of connexin 36 in this process. Pregnant C57BL/6J mice were injected with IL-6 on gestational day 15. The levels of i...

journal_title：Developmental neuroscience

authors： Wang R,Yang Y,Xiao M,Guo B,Liu W,Wang H

更新日期：2019-01-01 00:00:00

abstract：:Insulin binding was measured on crude mitochondrial or plasma membranes prepared from different rat brain regions during postnatal development. In the cerebral cortex and brainstem, insulin binding decreased 60-70% between birth and the adult period. In the cerebellum, insulin binding doubled in the first 10 postnatal...

journal_title：Developmental neuroscience

authors： Marks JL,Eastman CJ

更新日期：1990-01-01 00:00:00

abstract：:The distribution of the noradrenergic system within the rat cerebellar cortex following low-level X-irradiation was studied using tyrosine hydroxylase immunocytochemistry. X-Irradiation treatments consisted of 1, 3, or 5 successive daily dose beginning on postnatal day 1. When studied 24 h after the last exposure, a d...

journal_title：Developmental neuroscience

authors： Kunkler PE,Anderson WJ

更新日期：1994-01-01 00:00:00

abstract：:Myelin-associated oligodendrocytic basic protein (MOBP) and myelin basic protein (MBP) share many structural similarities. MOBP is synthesised by mature oligodendrocytes and localised at the major dense line (MDL), suggesting a role in the myelin compaction process. The shiverer mouse, a deletion mutant of the myelin ...

journal_title：Developmental neuroscience

authors： Montague P,Kirkham D,McCallion AS,Davies RW,Kennedy PG,Klugmann M,Nave K,Griffiths IR

更新日期：1999-01-01 00:00:00

abstract：:Creatine kinase (CK) isoenzymes, with emphasis on the mitochondrial CK isoenzymes, were characterized and localized in chicken cerebellum. Chicken cerebellum extracts analyzed by two-dimensional gels, using antipeptide antibodies specific for sarcomeric muscle-type mitochondrial CK (Mib-CK) and revealed the presence o...

journal_title：Developmental neuroscience

authors： Kaldis P,Hemmer W,Zanolla E,Holtzman D,Wallimann T

更新日期：1996-01-01 00:00:00

abstract：:In some cells, the development of voltage-gated channels requires synaptic input, while in others it does not. Here we investigate whether the sodium and potassium currents in the skeletal muscle of zebrafish sofa potato (sop(-/-)) mutants develop normally. Zebrafish sop(-/-) mutants do not express nicotinic acetylcho...

journal_title：Developmental neuroscience

authors： Coutts CA,Cunningham ME,Ali DW

更新日期：2009-01-01 00:00:00

abstract：:Oligodendrocytes from the shiverer mutant mouse are missing most of the myelin basic protein (Mbp) gene. In axon-free cultures, they produce membrane sheets with abnormally assembled microtubule and actin-based structures. This suggests that an Mbp gene product may have an important role in regulating the organization...

journal_title：Developmental neuroscience

authors： Dyer CA,Phillbotte T,Wolf MK,Billings-Gagliardi S

更新日期：1997-01-01 00:00:00

abstract：:Perinatal hypoxic ischemic (HI) brain injury is a leading cause of long-term neurological handicap in newborn babies. Recently, excessive activity of matrix metalloproteinases (MMPs), and in particular MMP-9, has been implicated in the aetiology of HI injuries to the immature brain. Our previous study suggested that M...

journal_title：Developmental neuroscience

authors： Ranasinghe HS,Scheepens A,Sirimanne E,Mitchell MD,Williams CE,Fraser M

更新日期：2012-01-01 00:00:00

abstract：:The norepinephrine content of hypothalamus in vehicle-treated control rats gradually increases between days 16 and 45 of life. Norepinephrine contents of the hypothalamus and mesencephalon of the thyroxine-treated (10 microgram/g b.w., s.c., days 8-10) animals also increase between days 16 and 21. Mesencephalic and hy...

journal_title：Developmental neuroscience

authors： Lengvári I,Branch BJ,Taylor AN

更新日期：1980-01-01 00:00:00

abstract：:Chick embryo retina neurons in culture extend neurites and form synapses. Seven different culture substrates were compared to determine which culture surface would produce the best neuronal survival and neurite extension. The order of survival of retina neurons during 7 days of culture is salt-precipitated collagen gr...

journal_title：Developmental neuroscience

authors： Thompson JM,Pelto DJ

更新日期：1982-01-01 00:00:00