Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain.

Abstract:

:The postnatal development of the complexes of the electron transport chain in mitochondria isolated from rat brain synaptosomes was investigated. Synaptosomal brain mitochondria were isolated from rats aged 10-60 days, and the activities of mitochondrial complex I, complex II-III, complex IV and complex V were measured. There was a significant increase in the activity of II-III from day 10 to day 15 and complex IV from day 10 to day 21, thereafter the activities of complexes I-III and IV did not change significantly. The activity of complex I did not change significantly during the period 10-60 days post partum. In synaptic mitochondria, complex V activity was higher than in non-synaptic mitochondria, whereas the activity of complex I was lower than in non-synaptic mitochondria. These data show that the complexes of the respiratory chain within synaptic mitochondria have activities different from those of non-synaptic mitochondria and may have major implications for the relative susceptibility of mitochondria in different brain cell types to neurotoxins such as MPP+, hypoxic/ischaemic damage and oxidative stress.

journal_name

Dev Neurosci

authors

Almeida A,Brooks KJ,Sammut I,Keelan J,Davey GP,Clark JB,Bates TE

doi

10.1159/000111289

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

212-8

issue

4

eissn

0378-5866

issn

1421-9859

journal_volume

17

pub_type

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