Expression and modulation of K+ currents in oligodendrocytes: possible role in myelinogenesis.

abstract：:Perinatal hypoxic ischemic (HI) brain injury is a leading cause of long-term neurological handicap in newborn babies. Recently, excessive activity of matrix metalloproteinases (MMPs), and in particular MMP-9, has been implicated in the aetiology of HI injuries to the immature brain. Our previous study suggested that M...

journal_title：Developmental neuroscience

authors： Ranasinghe HS,Scheepens A,Sirimanne E,Mitchell MD,Williams CE,Fraser M

更新日期：2012-01-01 00:00:00

abstract：:Dissociated brain cell cultures are a useful model for investigating development and differentiation of oligodendrocytes in vitro. The current studies compare the developmental patterns of expression for oligodendrocyte lineage/myelin markers in both primary and secondary oligodendrocyte cultures derived from mouse an...

journal_title：Developmental neuroscience

authors： Duchala CS,Asotra K,Macklin WB

更新日期：1995-01-01 00:00:00

abstract：:The effects of hyperbaric exposure with high oxygen concentration on the physical activity of developing male rats were investigated. Five-week-old male rats were exposed to an atmospheric pressure of 1.25 with an oxygen concentration of 36.0% for 12 h (7.00-19.00 h) and exercised voluntarily for 12 h (19.00-7.00 h) d...

journal_title：Developmental neuroscience

authors： Matsumoto A,Okiura T,Morimatsu F,Ohira Y,Ishihara A

更新日期：2007-01-01 00:00:00

abstract：:Prenatal fever could result in brain function impairments in the offspring. The present study investigated the effect of interleukin-6 (IL-6)-induced maternal fever on the offspring and the involvement of connexin 36 in this process. Pregnant C57BL/6J mice were injected with IL-6 on gestational day 15. The levels of i...

journal_title：Developmental neuroscience

authors： Wang R,Yang Y,Xiao M,Guo B,Liu W,Wang H

更新日期：2019-01-01 00:00:00

abstract：:Ethanol inhibition of L1-mediated cell adhesion may contribute to the spectrum of neurological, behavioral and morphological abnormalities associated with prenatal ethanol exposure. We showed previously that the neuroprotective peptides NAPVSIPQ (NAP) and SALLRSIPA (SAL) antagonize ethanol inhibition of L1 adhesion an...

journal_title：Developmental neuroscience

authors： Chen SY,Charness ME,Wilkemeyer MF,Sulik KK

更新日期：2005-01-01 00:00:00

abstract：:Uncertainty reigns over whether or not glutamate uptake in astrocytes leads to strong stimulation of glucose utilization, measured as accumulation of radioactive deoxyglucose-6-phosphate. This is an important issue, not only because glutamate is the major excitatory transmitter, but also because it has been postulated...

journal_title：Developmental neuroscience

authors： Hertz L,Swanson RA,Newman GC,Marrif H,Juurlink BH,Peng L

更新日期：1998-01-01 00:00:00

abstract：:Steroid hormones have profound effects on vertebrate behaviors. Yet, in most cases we can neither identify the neurons responsible for particular behaviors nor how steroids alter their excitability. Electric fish emit sexually dimorphic electric organ discharges (EODs) the waveform of which may be altered by steroid t...

journal_title：Developmental neuroscience

authors： Zakon HH

更新日期：1996-01-01 00:00:00

abstract：:The cell line MN9D, a fusion of embryonic ventral mesencephalic and neuroblastoma cells, is extensively used as a model of dopamine (DA) neurons because it expresses tyrosine hydroxylase and synthesizes and releases DA. These cells are also used to test mechanisms and potential therapeutics relevant to the loss of DA ...

journal_title：Developmental neuroscience

authors： Rick CE,Ebert A,Virag T,Bohn MC,Surmeier DJ

更新日期：2006-01-01 00:00:00

abstract：:Excitotoxicity plays a key role during insults to the developing brain such as neonatal encephalopathy, stroke, and encephalopathy of prematurity. Such insults affect many thousands of infants each year. Excitotoxicity causes frank lesions due to cell death and gliosis and disturbs normal developmental process, leadin...

journal_title：Developmental neuroscience

authors： Blaise BJ,Schwendimann L,Chhor V,Degos V,Hodson MP,Dallmann G,Keller M,Gressens P,Fleiss B

更新日期：2017-01-01 00:00:00

abstract：:Developing neurons synthesize substantial quantities of membrane phospholipids in producing new synapses. We investigated the effects of maternal uridine (as uridine-5'-monophosphate) and docosahexaenoic acid supplementation on pups' brain phospholipids, synaptic proteins and dendritic spine densities. Dams consumed n...

journal_title：Developmental neuroscience

authors： Cansev M,Marzloff G,Sakamoto T,Ulus IH,Wurtman RJ

更新日期：2009-01-01 00:00:00

abstract：:In this study we have examined the susceptibility of the mitochondrial respiratory chain of astrocytes and astrocytes depleted of glutathione to peroxynitrite exposure. Astrocytes, as reported previously by us, appeared resistant to the actions of peroxynitrite. In contrast, depletion (-94%) of astrocytic glutathione ...

journal_title：Developmental neuroscience

authors： Barker JE,Bolaños JP,Land JM,Clark JB,Heales SJ

更新日期：1996-01-01 00:00:00

abstract：:We studied the developmental changes of soluble and membrane-bound protein kinases (EC 2.7.1.37) in rat brain and found that the elution profiles from a DEAE-cellulose column by NaCl of adenosine-3':5'-monophosphate (cyclic AMP) dependent protein kinase from cytosol were not significantly different in newborn (0.19 M ...

journal_title：Developmental neuroscience

authors： Kinnier WJ,Chikvaidze V,Hollenbeck RA,Chuang DM,Costa E

更新日期：1979-01-01 00:00:00

abstract：:Adult neuronal ceroid lipofuscinosis (NCL), also called Kufs' disease, is clinically distinct from the other NCLs. It is a rare condition which is difficult to diagnose. More than 50% of the reported cases of Kufs' disease are not adult NCL and correspond very likely to a heterogeneous spectrum of lipidoses. Various c...

journal_title：Developmental neuroscience

authors： Martin JJ

更新日期：1991-01-01 00:00:00

abstract：:The effect of undernutrition on the activity of glutamate decarboxylase (GAD) and choline acetyltransferase (ChAc) (markers for the GABA-ergic and the cholinergic transmitter system, respectively) was studied in various parts of the rat brain at the age of 10, 15 and 21 days, and at day 54 following 33 days of rehabil...

journal_title：Developmental neuroscience

authors： Patel AJ,del Vecchio M,Atkinson DJ

更新日期：1978-01-01 00:00:00

abstract：:The neonatal brain appears to be selectively vulnerable to oxidative stress. Several potential mechanisms associated with altered reactive oxygen species metabolism would explain the increased susceptibility. They include increased accumulation of hydrogen peroxide with subsequent neurotoxicity. This enhanced neurotox...

journal_title：Developmental neuroscience

authors： Ferriero DM

更新日期：2001-01-01 00:00:00

abstract：:Previous studies have demonstrated that exposure to ethanol during development delays the rate at which axons in certain central nervous system tracts acquire myelin. This delay appears to be related to an alteration in oligodendrocyte function and not to an aberrancy in axon size or number. The present study was desi...

journal_title：Developmental neuroscience

authors： McNeill DL,Shew RL,Papka RE

更新日期：1991-01-01 00:00:00

abstract：:Radiotherapy is an effective treatment strategy in the treatment of brain tumors, but it is also a major cause of long-term complications, especially in survivors of pediatric brain tumors. Cognitive decline caused by cranial radiotherapy is thought, at least partly, to depend on injury to stem and progenitor cells in...

journal_title：Developmental neuroscience

authors： Roughton K,Andreasson U,Blomgren K,Kalm M

更新日期：2013-01-01 00:00:00

abstract：:Early research in the Vannucci laboratory prior to 1981 focused largely on brain energy metabolism in the developing rat. At that time, there was no experimental model to study the effects of perinatal hypoxia-ischemia in the rodent, despite the tremendous need to investigate the pathophysiology of perinatal asphyxial...

journal_title：Developmental neuroscience

authors： Vannucci RC,Vannucci SJ

更新日期：2005-03-01 00:00:00

abstract：:In the era of therapeutic hypothermia, reliable preclinical studies are integral to successfully identify neuroprotective strategies to further improve outcomes of encephalopathy at term. We reviewed preclinical neuroprotection studies reported between January 2014 and June 2016 to assess the use of effective temperat...

journal_title：Developmental neuroscience

authors： Galinsky R,Dean JM,Lear CA,Davidson JO,Dhillon S,Wassink G,Bennet L,Gunn AJ

更新日期：2017-01-01 00:00:00

abstract：:Neurotoxicological studies have indicated that L-glutamate exhibits more pronounced effects on the preoptic area (POA) neurons of male rats than on those of females in the neonatal period. However, no information has previously been available as to whether or not such sexual dimorphism also exists for the effects of g...

journal_title：Developmental neuroscience

authors： Hsu C,Hsieh YL,Ho ML,Hsu HK,Yu JY

更新日期：2001-01-01 00:00:00

abstract：:There are distinct symptoms for attention deficit hyperactivity disorder (ADHD) at different ages. To explore the developmental mechanism of ADHD from childhood to adolescence, patients from different age groups with ADHD drawn from a large dataset should be investigated. In this study, we hypothesized that there are ...

journal_title：Developmental neuroscience

authors： Tang C,Wei Y,Zhao J,Nie J

更新日期：2018-01-01 00:00:00

abstract：:Reactive oxygen species (ROS) have been reported to affect neural stem cell self-renewal and therefore may be important for normal development and may influence neurodegenerative processes when ROS activity is elevated. To determine if increasing production of superoxide, via activation of NADPH oxidase (Nox), increas...

journal_title：Developmental neuroscience

authors： Topchiy E,Panzhinskiy E,Griffin WS,Barger SW,Das M,Zawada WM

更新日期：2013-01-01 00:00:00

abstract：:Glutamine synthesis, the major pathway of ammonia detoxification, and the intracellular concentration of organic osmolytes in primary astrocytes and F98 glioma cells were investigated with multinuclear magnetic resonance spectroscopy. Acute exposure to ammonia (3 h incubation with NH4Cl) raised the concentration of gl...

journal_title：Developmental neuroscience

authors： Zwingmann C,Brand A,Richter-Landsberg C,Leibfritz D

更新日期：1998-01-01 00:00:00

abstract：:Transient early cerebral laminar organization resulting from normal developmental events has been revealed in human beings through histology and imaging studies. DTI studies have postulated that the fractional anisotropy (FA)-based differentiation of different laminar structures reflects both differing cellular densit...

journal_title：Developmental neuroscience

authors： Trivedi R,Husain N,Rathore RK,Saksena S,Srivastava S,Malik GK,Das V,Pradhan M,Pandey CM,Gupta RK

更新日期：2009-01-01 00:00:00

abstract：:Various abnormalities in frontal and striatal regions have been reported in children with prenatal alcohol and/or methamphetamine exposure. In a recent fMRI study, we observed a correlation between accuracy on a working-memory task and functional activation in the putamen in children with prenatal methamphetamine and ...

journal_title：Developmental neuroscience

authors： Roussotte FF,Rudie JD,Smith L,O'Connor MJ,Bookheimer SY,Narr KL,Sowell ER

更新日期：2012-01-01 00:00:00

abstract：:Preadolescent animals display protracted hormonal stress responses mediated by the hypothalamic-pituitary-adrenal (HPA) axis compared to adults. Though the mechanisms that underlie this shift in stress reactivity are unknown, reduced glucocorticoid-dependent negative feedback on the HPA axis has been posited to contri...

journal_title：Developmental neuroscience

authors： Dziedzic N,Ho A,Adabi B,Foilb AR,Romeo RD

更新日期：2014-01-01 00:00:00

abstract：:Perinatal asphyxia is a leading cause of brain injury in neonates, occurring in 2-4 per 1,000 live births, and there are limited treatment options. Because of their similarity to humans, nonhuman primates are ideal for performing preclinical tests of safety and efficacy for neurotherapeutic interventions. We previousl...

journal_title：Developmental neuroscience

authors： Jacobson Misbe EN,Richards TL,McPherson RJ,Burbacher TM,Juul SE

更新日期：2011-01-01 00:00:00

abstract：:Early developmental processes, such as metabolic programming, can provide cues to an organism, which allow it to make modifications that are predicted to be beneficial for survival. Similarly, social play has a multifaceted role in promoting survival and fitness of animals. Play is a complex behavior that is greatly i...

journal_title：Developmental neuroscience

authors： Hehar H,Ma I,Mychasiuk R

更新日期：2016-01-01 00:00:00

abstract：:Autism spectrum disorder (ASD) comprises a group of neurodevelopmental disorders characterized by social deficits and stereotyped behaviors. While several theories have emerged, the pathogenesis of ASD remains unknown. Although studies report dopamine signaling abnormalities in autistic patients, a coherent dopamine h...

journal_title：Developmental neuroscience

authors： Pavăl D

更新日期：2017-01-01 00:00:00

abstract：:The medial frontal cortex (MFC) is involved in the temporal organization of behaviour. It receives timing information from the master circadian clock in the suprachiasmatic nucleus (SCN), and exhibits daily oscillations in gene expression itself. In this study, we evaluate various properties of circadian rhythms of lo...

journal_title：Developmental neuroscience

authors： Phillips CI,Smith VM,Antle MC,Dyck RH

更新日期：2009-01-01 00:00:00