Abstract：
:Early developmental processes, such as metabolic programming, can provide cues to an organism, which allow it to make modifications that are predicted to be beneficial for survival. Similarly, social play has a multifaceted role in promoting survival and fitness of animals. Play is a complex behavior that is greatly influenced by motivational and reward circuits, as well as the energy reserves and metabolism of an organism. This study examined the association between metabolic programming and juvenile play behavior in an effort to further elucidate insight into the consequences that early adaptions have on developmental trajectories. The study also examined changes in expression of four genes (Drd2, IGF1, Opa1, and OxyR) in the prefrontal cortex known to play significant roles in reward, bioenergetics, and social-emotional functioning. Using four distinct variations in developmental programming (high-fat diet, caloric restriction, exercise, or high-fat diet combined with exercise), we found that dietary programming (high-fat diet vs. caloric restriction) had the greatest impact on play behavior and gene expression. However, exercise also induced changes in both measures. This study demonstrates that metabolic programming can alter neural circuits and bioenergetics involved in play behavior, thus providing new insights into mechanisms that allow programming to influence the evolutionary success of an organism.
journal_name
Dev Neuroscijournal_title
Developmental neuroscienceauthors
Hehar H,Ma I,Mychasiuk Rdoi
10.1159/000444015subject
Has Abstractpub_date
2016-01-01 00:00:00pages
96-104issue
2eissn
0378-5866issn
1421-9859pii
000444015journal_volume
38pub_type
杂志文章abstract：:Necrotizing enterocolitis (NEC) increases the risk of brain injury and impaired neurodevelopment. Rapid brain maturation prior to birth may explain why preterm brains are particularly vulnerable to serious infections. Using pigs as models, we hypothesized that preterm birth was associated with altered blood-cerebrospi...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000488979
更新日期：2018-01-01 00:00:00
abstract：:Early research in the Vannucci laboratory prior to 1981 focused largely on brain energy metabolism in the developing rat. At that time, there was no experimental model to study the effects of perinatal hypoxia-ischemia in the rodent, despite the tremendous need to investigate the pathophysiology of perinatal asphyxial...
journal_title：Developmental neuroscience
pub_type： 杂志文章,评审
doi：10.1159/000085978
更新日期：2005-03-01 00:00:00
abstract：:The fine structure of pituicytes was investigated between 15 days of fetal life and 120 days postnatum. Prior to the penetration of neurosecretory axons into the neural lobe a uniform population of undifferentiated pituicytes is presented. Coincidental with the first appearance of neurosecretory axons in the neural lo...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000112744
更新日期：1981-01-01 00:00:00
abstract：:Developmental expression of neutral monoglycosylceramides (MGCs) has been examined in rat brain from embryonic day 15 (E15) to postnatal day 30 (P30) and adulthood. To this point, glucosylceramide (GlcCer) is the only MGC that has been characterized in embryonic brain. Galactosylceramide (GalCer) appears at P1, increa...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000111201
更新日期：1997-01-01 00:00:00
abstract：:Neural stem cells are attracting enormous attention in regenerative medicine due to their ability to self-renew and differentiate into the cell lineages that constitute the central nervous system. However, little is known about the mechanism underlying the regulation of their redox environment, which is essential for ...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000493009
更新日期：2018-01-01 00:00:00
abstract：:The spontaneously immortalized S16 Schwann cell line expresses higher levels of myelin-associated glycoprotein (MAG) and PO glycoprotein and their messenger RNAs when grown at high density than at low density [Sasagasako et al: J Neurochem 1996;66:1432-1439]. This up-regulation of myelin protein expression at high den...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000017409
更新日期：1999-01-01 00:00:00
abstract：:NeuroD is a basic helix-loop-helix (bHLH) transcription factor cloned from a two hybrid screen designed to search for new bHLH proteins. In our previous studies, we showed that NeuroD could convert Xenopus ectoderm into fully differentiated neurons and that it could prematurely differentiate neural precursor cells in ...
journal_title：Developmental neuroscience
pub_type： 杂志文章,评审
doi：10.1159/000111182
更新日期：1997-01-01 00:00:00
abstract：:The auditory system of the cricket has the unusual ability to respond to deafferentation by compensatory growth and synapse formation. Auditory interneurons such as ascending neuron 2 (AN-2) in the cricket Gryllus bimaculatus possess a dendritic arbor that normally grows up to, but not over, the midline of the prothor...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000322887
更新日期：2011-01-01 00:00:00
abstract：:Maternal inflammation has been linked to neurodevelopmental and neuropsychiatric disorders such as cerebral palsy, schizophrenia, and autism. We had previously shown that intrauterine inflammation resulted in a decrease in serotonin, one of the tryptophan metabolites, and a decrease in serotonin fibers in the sensory ...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000471509
更新日期：2017-01-01 00:00:00
abstract：:Evidence from retroviral marking techniques and immortalized cell lines indicates that multipotential stem cells exist in many areas of the developing central nervous system. However, the factors that influence the commitment of these stem cells into distinct neuronal or glial lineages are not known. We have created a...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000111301
更新日期：1995-01-01 00:00:00
abstract：:Cultures of rat oligodendrocytes were used to test the possible role of the cerebellar soluble lectin (CSL) in myelin formation. Immunocytochemistry at the ultrastructural level showed that the lectin is present in the cytoplasm of the perikaryon of cultured oligodendrocytes and also on the plasma membrane of the cell...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000111970
更新日期：1988-01-01 00:00:00
abstract：:The medial frontal cortex (MFC) is involved in the temporal organization of behaviour. It receives timing information from the master circadian clock in the suprachiasmatic nucleus (SCN), and exhibits daily oscillations in gene expression itself. In this study, we evaluate various properties of circadian rhythms of lo...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000232559
更新日期：2009-01-01 00:00:00
abstract：:The gene responsible for the audiogenic seizure (AGS) phenotype in Frings mice, which was identified and originally designated Mass1, is now referred to as Mgr1. Although the function of the gene product is not known, the expression pattern suggests a role in the developing CNS. Hearing impairment is often observed in...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000086712
更新日期：2005-01-01 00:00:00
abstract：:As a step toward using two closely related members of the nuclear receptor family, RORalpha and RORbeta, as markers and tools for genetic manipulations in mouse forebrain, we have used in situ hybridization to analyze their expression from E10.5 to P7. At later embryonic and early postnatal ages, RORalpha expression i...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000072271
更新日期：2003-03-01 00:00:00
abstract：:We report on the effects of etiology and age on the linguistic outcomes in a large pediatric hemispherectomy population. Four populations were considered separately: cortical dysplasia (multilobar involvement), Rasmussen's encephalitis, infarction as a primary etiology and, fourth, children who failed to develop langu...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000017396
更新日期：1999-11-01 00:00:00
abstract：:In adult rats, kainic acid-induced status epilepticus markedly reduces GluR2 (the alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid, AMPA subunit that limits Ca2+ permeability), receptor mRNA in the vulnerable CA3 and may contribute to delayed neurodegeneration. In rat pups resistant to kainate seizure-induced...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000111257
更新日期：1997-01-01 00:00:00
abstract：:To define the effects of neurotrophins on oligodendrocytes, we monitored NGF, BDNF and NT-3 actions on basal forebrain (BF) and cortical populations. NGF, BDNF and NT-3 applied to BF oligodendrocytes elicited increases in expression of myelin basic protein (MBP) and enhanced the numbers of MBP+ cells, without affectin...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000072261
更新日期：2003-03-01 00:00:00
abstract：:Quaking is a neurological mutation leading to pleiotropic phenotypic expression, the most prominent being disturbed myelin formation in the central nervous system (CNS) with minor abnormalities in the peripheral nervous system. Previous immunochemical measurements of glial fibrillary acidic protein (GFAP) revealed a m...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000111682
更新日期：1992-01-01 00:00:00
abstract：:Maternal peptides from the hypothalamic-pituitary-adrenal (HPA) axis rise during human pregnancy. The effects of circulating maternal adrenocorticotropin (ACTH) and beta-endorphin (BE) on human fetal behavior was determined in 135 women during their 32nd week of gestation. Fetal behavior was measured by assessing hear...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000071467
更新日期：2003-01-01 00:00:00
abstract：:Our previous studies of H218, a sphingosine 1-phosphate (S1P) receptor and a member of the G-protein-coupled receptor superfamily, suggest that it may participate in mammalian nervous system development. Thus, brain levels of H218 mRNA are higher during early neurogenesis than postnatally. In addition, embryonic H218 ...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000017452
更新日期：2000-01-01 00:00:00
abstract：:In order to investigate the possible influence of norepinephrine (NE) on neuronal development, the effects of neonatal NE depletion on postnatally developing cell populations were characterized in (1) the normal mouse cerebellum, and (2) a cerebellar model system with delayed germinal cell development produced by neon...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000112695
更新日期：1982-01-01 00:00:00
abstract：:Recent studies have shown a protection from cerebral hypoxic-ischemic (HI) brain damage in the immature rat following a prior systemic hypoxic exposure when compared with those not exposed previously. To investigate the mechanism(s) of hypoxic preconditioning, brain glycogen and high-energy phosphate reserves were mea...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000069051
更新日期：2002-01-01 00:00:00
abstract：:Choline acetyltransferase (ChAT), the biosynthetic enzyme for acetylcholine metabolism, is expressed in a human cholinergic neuroblastoma cell line; MC-IXC. We demonstrate that ChAT activity is regulated in this cell line by cell density. It is believed that the mechanism of stimulation of enzyme activity involves cel...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000111975
更新日期：1988-01-01 00:00:00
abstract：:The cytoskeleton of a newly isolated mouse embryo brain-derived cell line and of dissected mesencephalon-rhombencephalon samples of the 10- to 11-day-old mouse embryo, constituted of a ventricular zone only, has been examined by immunocytochemistry, electrophoretic separation and Western blotting techniques. In accord...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000111612
更新日期：1987-01-01 00:00:00
abstract：:Dissociated cells of cerebral hemispheres from 8-day-old chick embryos were cultivated for 8 days in polylysine-coated Petri dishes. Changes of DNA, RNA, total proteins, putrescine, spermidine, spermine, free amino acids and enzymes involved in polyamine and GABA metabolism were studied throughout neuronal development...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000112755
更新日期：1981-01-01 00:00:00
abstract：:The neurotoxic effect of monosodium L-glutamate (MSG) on the morphologies in the darkly stained sexually dimorphic nucleus of the preoptic area (SDN-POA) and the lighter-staining surrounding area (non-SDN-POA) within the medial preoptic nucleus (MPN) was evaluated. Male and female Long-Evans rats were used. MSG (4 mg/...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000111231
更新日期：1997-01-01 00:00:00
abstract：:Striatal neurons are highly vulnerable to hypoxia-ischemia (HI) in term newborns. In a piglet model of HI, striatal neurons develop oxidative stress and organelle disruption by 3-6 h of recovery and ischemic cytopathology over 6-24 h of recovery. We tested the hypothesis that early treatment with the antioxidants EUK-...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000327243
更新日期：2011-01-01 00:00:00
abstract：:The current work tested the hypothesis that the zinc status of a cell influences its sensitivity to iron-induced oxidative stress. Human IMR-32 neuroblastoma cells were cultured for 24 h in nonchelated control media (5 microM zinc; 4.5 microM iron), or in media that was treated with DTPA to reduce its zinc content (ch...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000065691
更新日期：2002-01-01 00:00:00
abstract：:We have previously provided evidence that ferritin binds selectively to white matter tracts in adult mouse and human brains. In cell culture experiments, ferritin binding is specifically localized to oligodendrocytes. The goal of the present study is to test the hypothesis that the developmental pattern for ferritin b...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000065704
更新日期：2002-01-01 00:00:00
abstract：:Apoptosis contributes greatly to the morphological and biochemical features of cell death after neonatal cerebral hypoxia-ischemia (HI), making this mode of cell death a promising therapeutic target. We previously showed that 10 mg/kg of the caspase inhibitor Q-VD-OPh at the onset of and immediately after HI on postna...
journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000357939
更新日期：2014-01-01 00:00:00
