Abstract:
:It has been hypothesized that changes in striatal-mediated dopamine modulation during adolescence may increase the risk for initiating substance abuse as a result of its fundamental role in arbitrating reward sensitivity and motivation during learning and decision making. However, substance abuse during adolescence may also significantly modify striatal structure and function and concomitantly alter reward sensitivity and action control while this brain region is undergoing remodeling. In the present investigation, to assess the relationship of methamphetamine (Meth) or Meth and cannabis (CA) abuse to regional striatal morphology, we acquired structural magnetic resonance images, using a 3T Siemens Trio scanner, from three groups of adolescents composed of healthy controls (n = 10), Meth abusers (n = 9) and combined Meth and CA abusers (Meth+CA, n = 8). We also assessed novelty seeking using the novelty seeking subscale of Cloninger's Tridimensional Character Inventory. The results indicate that adolescent Meth+CA abusers have increased regional striatal volume and show intensified novelty seeking in contrast to the controls. The degree of Meth exposure was also positively correlated with regional striatal volume and novelty seeking in both the Meth and Meth+CA users. These preliminary findings support theories that propose a role for the striatum in adolescent substance abuse and further indicate that novelty seeking may be related to the initiation of, or sustained, drug use.
journal_name
Dev Neuroscijournal_title
Developmental neuroscienceauthors
Churchwell JC,Carey PD,Ferrett HL,Stein DJ,Yurgelun-Todd DAdoi
10.1159/000337724subject
Has Abstractpub_date
2012-01-01 00:00:00pages
310-7issue
4eissn
0378-5866issn
1421-9859pii
000337724journal_volume
34pub_type
杂志文章abstract::Neuroblastoma is a childhood cancer caused by the transformation of sympathoadrenal progenitors. By following the formation of tumors in homozygous TH-MYCN mice, an established mouse model of neuroblastoma, we were able to capture transformed cells prior to the formation of large, vascularized tumors in order to deter...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000365281
更新日期:2014-01-01 00:00:00
abstract::Prenatal fever could result in brain function impairments in the offspring. The present study investigated the effect of interleukin-6 (IL-6)-induced maternal fever on the offspring and the involvement of connexin 36 in this process. Pregnant C57BL/6J mice were injected with IL-6 on gestational day 15. The levels of i...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000499735
更新日期:2019-01-01 00:00:00
abstract::Although multipotent progenitor cells capable of generating neurons, astrocytes and oligodendrocytes are present within the germinal zones of the brain throughout embryonic, postnatal and adult life, the different neural cell types are generated within discrete temporospatial developmental windows. This might suggest ...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000017429
更新日期:2000-01-01 00:00:00
abstract::Fragile X syndrome (FXS) is a neurodevelopmental disorder characterized by intellectual disability, sensory hypersensitivity, and high incidences of autism spectrum disorders and epilepsy. These phenotypes are suggestive of defects in neural circuit development and imbalances in excitatory glutamatergic and inhibitory...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000329420
更新日期:2011-01-01 00:00:00
abstract::Cultures of rat oligodendrocytes were used to test the possible role of the cerebellar soluble lectin (CSL) in myelin formation. Immunocytochemistry at the ultrastructural level showed that the lectin is present in the cytoplasm of the perikaryon of cultured oligodendrocytes and also on the plasma membrane of the cell...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111970
更新日期:1988-01-01 00:00:00
abstract::When cells from the cerebellum of late-gestation rats were grown at low density (50-100 cells/mm2) in a three-dimensional culture system, they rapidly expressed morphological and electrophysiological properties of neurons. Growth and differentiation of the population of solitary neurons as a whole was statistically as...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111645
更新日期:1992-01-01 00:00:00
abstract::The long noncoding RNA MSNP1AS (moesin pseudogene 1, antisense) is a functional element that was previously associated with autism spectrum disorder (ASD) with genome-wide significance. Expression of MSNP1AS was increased 12-fold in the cerebral cortex of individuals with ASD and 22-fold in individuals with a genome-w...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000453258
更新日期:2016-01-01 00:00:00
abstract::Oligodendrocytes from the shiverer mutant mouse are missing most of the myelin basic protein (Mbp) gene. In axon-free cultures, they produce membrane sheets with abnormally assembled microtubule and actin-based structures. This suggests that an Mbp gene product may have an important role in regulating the organization...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111237
更新日期:1997-01-01 00:00:00
abstract::A study was made on the development of cortical synapses in the gracile nucleus of rats using degeneration methods. A total of 46 animals, 1 adult and 45 neonates whose ages varied from 1 to 7 days, had the right somatosensory motor cortex destroyed. The survival period varied from 1 to 30 days. Identification of axon...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112118
更新日期:1994-01-01 00:00:00
abstract::The M50 and M100 auditory evoked responses reflect early auditory processes in the primary/secondary auditory cortex. Although previous M50 and M100 studies have been conducted on individuals with autism spectrum disorder (ASD) and indicate disruption of encoding simple sensory information, analogous investigations of...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000504960
更新日期:2019-01-01 00:00:00
abstract::Prior studies suggest that non-canonical proteolipid protein (PLP) gene expression occurs during development in non-myelinating neurons as well as myelinating oligodendroglia in mammalian brain. To assess this possibility in neostriatum, a region of uncertain PLP gene expression in neurons, morphological and electroph...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000330321
更新日期:2011-01-01 00:00:00
abstract::Adult GM2 gangliosidosis is a rare autosomal recessive disease with widely varying neurological and psychiatric manifestations. It is caused by marked deficiency, but not total absence, of beta-hexosaminidase (Hex) A, due to a single base change in the alpha-subunit gene of Hex, resulting in a substitution of Ser for ...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112200
更新日期:1991-01-01 00:00:00
abstract::Dissociated cells of cerebral hemispheres from 8-day-old chick embryos were cultivated for 8 days in polylysine-coated Petri dishes. Changes of DNA, RNA, total proteins, putrescine, spermidine, spermine, free amino acids and enzymes involved in polyamine and GABA metabolism were studied throughout neuronal development...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112755
更新日期:1981-01-01 00:00:00
abstract::In adult rats, kainic acid-induced status epilepticus markedly reduces GluR2 (the alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid, AMPA subunit that limits Ca2+ permeability), receptor mRNA in the vulnerable CA3 and may contribute to delayed neurodegeneration. In rat pups resistant to kainate seizure-induced...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111257
更新日期:1997-01-01 00:00:00
abstract::This study investigated the time of expression of two endothelial cell adhesion molecules, ICAM-1/CD54 and PECAM-1/CD31 in the developing postpartum mouse blood-brain barrier (BBB). Immunoultrastructural studies demonstrated that both adhesion molecules are initially expressed primarily on the luminal endothelial cell...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000017352
更新日期:1998-01-01 00:00:00
abstract::Quaking is a neurological mutation leading to pleiotropic phenotypic expression, the most prominent being disturbed myelin formation in the central nervous system (CNS) with minor abnormalities in the peripheral nervous system. Previous immunochemical measurements of glial fibrillary acidic protein (GFAP) revealed a m...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111682
更新日期:1992-01-01 00:00:00
abstract::Traumatic brain injury (TBI) is predominantly a clinical problem of young persons, resulting in chronic cognitive and behavioral deficits. Specifically, the physiological response to a diffuse biomechanical injury in a maturing brain can clearly alter normal neuroplasticity. To properly evaluate and investigate develo...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000094163
更新日期:2006-01-01 00:00:00
abstract::The medial frontal cortex (MFC) is involved in the temporal organization of behaviour. It receives timing information from the master circadian clock in the suprachiasmatic nucleus (SCN), and exhibits daily oscillations in gene expression itself. In this study, we evaluate various properties of circadian rhythms of lo...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000232559
更新日期:2009-01-01 00:00:00
abstract::Traumatic brain injury (TBI) is the leading cause of death and disability in children. Evidence-based guidelines for the management of this population are available; however, the data highlight significant deficiencies with few treatment standards or guidelines. Considering the limited availability of resources, it is...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000094153
更新日期:2006-01-01 00:00:00
abstract::Nitric oxide (NO) is a recently recognized messenger molecule that has been shown to possess pleiotropic properties, including vasodilation, neurotransmission, cytotoxicity and antimicrobial activity. Constitutive and inducible forms of NO synthase (NOS) have been identified. Activation of cNOS releases relatively low...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000112102
更新日期:1994-01-01 00:00:00
abstract::The current work tested the hypothesis that the zinc status of a cell influences its sensitivity to iron-induced oxidative stress. Human IMR-32 neuroblastoma cells were cultured for 24 h in nonchelated control media (5 microM zinc; 4.5 microM iron), or in media that was treated with DTPA to reduce its zinc content (ch...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000065691
更新日期:2002-01-01 00:00:00
abstract::Perinatal asphyxia is a leading cause of brain injury in neonates, occurring in 2-4 per 1,000 live births, and there are limited treatment options. Because of their similarity to humans, nonhuman primates are ideal for performing preclinical tests of safety and efficacy for neurotherapeutic interventions. We previousl...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000327246
更新日期:2011-01-01 00:00:00
abstract::Stromal-derived factor 1 (SDF-1), a known chemoattractant, and its receptor CXCR4 are widely expressed in the developing and adult cerebral cortex. Recent studies have highlighted potential roles for SDF-1 during early cortical development. In view of the current findings, our histological analysis has revealed a dist...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000109857
更新日期:2008-01-01 00:00:00
abstract::Early developmental treatment of rats with 3,4-methylenedioxymethamphetamine (MDMA) was previously found to cause an abnormal pattern of forebrain serotonergic axon density in adulthood consisting of a cortical hypoinnervation and a striatal hyperinnervation. The present study tested the hypothesis that this reorganiz...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000207497
更新日期:2009-01-01 00:00:00
abstract::Choline acetyltransferase (ChAT), the biosynthetic enzyme for acetylcholine metabolism, is expressed in a human cholinergic neuroblastoma cell line; MC-IXC. We demonstrate that ChAT activity is regulated in this cell line by cell density. It is believed that the mechanism of stimulation of enzyme activity involves cel...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111975
更新日期:1988-01-01 00:00:00
abstract::Nogo is a member of the reticulon family. Our understanding of the physiological functions of the Nogo-A protein has grown over the last few years, and this molecule is now recognized as one of the most important axonal regrowth inhibitors present in central nervous system (CNS) myelin. Nogo-A plays other important ro...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000343143
更新日期:2012-01-01 00:00:00
abstract::We have previously provided evidence that ferritin binds selectively to white matter tracts in adult mouse and human brains. In cell culture experiments, ferritin binding is specifically localized to oligodendrocytes. The goal of the present study is to test the hypothesis that the developmental pattern for ferritin b...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000065704
更新日期:2002-01-01 00:00:00
abstract::The kinetics and sodium-dependence of gamma-aminobutyric acid (GABA), hypotaurine and taurine uptake were analyzed in cerebral slices prepared from mice of different postnatal ages. The maximal velocities of transport (V) and the Km constants for the high-affinity uptake all decreased with age, whereas the development...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112354
更新日期:1983-01-01 00:00:00
abstract::Evidence from retroviral marking techniques and immortalized cell lines indicates that multipotential stem cells exist in many areas of the developing central nervous system. However, the factors that influence the commitment of these stem cells into distinct neuronal or glial lineages are not known. We have created a...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111301
更新日期:1995-01-01 00:00:00
abstract::The postnatal developmental expression and the distribution of the glutamate transporters (GLAST, GLT-1 and EAAC1) were analyzed in rat vestibular nuclei (VN), at birth and during the following 4 weeks. Analyses were performed using reverse transcriptase-polymerase chain reaction and immunoblotting of GLAST, GLT-1 and...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000073510
更新日期:2003-09-01 00:00:00