Stromal-derived factor 1 signalling regulates radial and tangential migration in the developing cerebral cortex.

abstract：:Maternal inflammation has been linked to neurodevelopmental and neuropsychiatric disorders such as cerebral palsy, schizophrenia, and autism. We had previously shown that intrauterine inflammation resulted in a decrease in serotonin, one of the tryptophan metabolites, and a decrease in serotonin fibers in the sensory ...

journal_title：Developmental neuroscience

authors： Williams M,Zhang Z,Nance E,Drewes JL,Lesniak WG,Singh S,Chugani DC,Rangaramanujam K,Graham DR,Kannan S

更新日期：2017-01-01 00:00:00

abstract：:We investigated the effects of perinatal hypoxia-ischemia (HI) on brain injury and neurological functional outcome at postnatal day (P)30 through P90. HI was induced by exposing P9 mice to 8% O(2) for 55 min using the Vannucci HI model. Following HI, mice were treated with either vehicle control or Na(+)/H(+) exchange...

journal_title：Developmental neuroscience

authors： Cengiz P,Uluc K,Kendigelen P,Akture E,Hutchinson E,Song C,Zhang L,Lee J,Budoff GE,Meyerand E,Sun D,Ferrazzano P

更新日期：2011-01-01 00:00:00

abstract：:In this study, the proliferative activity of cultured chick neuroblasts exposed to high or low concentrations of fetal calf serum (FCS) was investigated. Different experimental evidences showed that the first 2-3 days of culture correspond to a period of neuronal proliferation in our culture conditions, whereas contam...

journal_title：Developmental neuroscience

authors： Barakat I,Labourdette G,Sensenbrenner M

更新日期：1983-01-01 00:00:00

abstract：:The cell line MN9D, a fusion of embryonic ventral mesencephalic and neuroblastoma cells, is extensively used as a model of dopamine (DA) neurons because it expresses tyrosine hydroxylase and synthesizes and releases DA. These cells are also used to test mechanisms and potential therapeutics relevant to the loss of DA ...

journal_title：Developmental neuroscience

authors： Rick CE,Ebert A,Virag T,Bohn MC,Surmeier DJ

更新日期：2006-01-01 00:00:00

abstract：:In this study we have examined the susceptibility of the mitochondrial respiratory chain of astrocytes and astrocytes depleted of glutathione to peroxynitrite exposure. Astrocytes, as reported previously by us, appeared resistant to the actions of peroxynitrite. In contrast, depletion (-94%) of astrocytic glutathione ...

journal_title：Developmental neuroscience

authors： Barker JE,Bolaños JP,Land JM,Clark JB,Heales SJ

更新日期：1996-01-01 00:00:00

abstract：:The incidence of stroke in children is 2.4 per 100,000 person-years and results in long-term motor and cognitive disability. In ischemic stroke, white matter (WM) is frequently injured, but is relatively understudied compared to grey matter injury. Previous research suggests that the cellular response to WM ischemic i...

journal_title：Developmental neuroscience

authors： Dingman AL,Rodgers KM,Dietz RM,Hickey SP,Frazier AP,Clevenger AC,Yonchek JC,Traystman RJ,Macklin WB,Herson PS

更新日期：2019-03-12 00:00:00

abstract：:Disorders primarily affecting the nervous system comprise approximately one third of all established Mendelian genetic diseases in man. Recombinant DNA technology provides new approaches to the diagnosis and elucidation of the molecular pathology of these disorders. For a small but increasing number of disorders the D...

journal_title：Developmental neuroscience

authors： Hayden MR,Nichols JL

更新日期：1983-01-01 00:00:00

abstract：:Systemic creatine (Cr) supplementation increases brain phosphocreatine (PCr) and prevents hypoxic seizures in 15-day-old rabbits. Between 5 and 30 days of age during normal development, rabbit gray matter mitochondrial creatine kinase (Mi-CK) increases 400% while cytosolic CK (BB-CK) increases 60%. In white matter, bo...

journal_title：Developmental neuroscience

authors： Kekelidze T,Khait I,Togliatti A,Holtzman D

更新日期：2000-09-01 00:00:00

abstract：:Glutamine synthesis, the major pathway of ammonia detoxification, and the intracellular concentration of organic osmolytes in primary astrocytes and F98 glioma cells were investigated with multinuclear magnetic resonance spectroscopy. Acute exposure to ammonia (3 h incubation with NH4Cl) raised the concentration of gl...

journal_title：Developmental neuroscience

authors： Zwingmann C,Brand A,Richter-Landsberg C,Leibfritz D

更新日期：1998-01-01 00:00:00

abstract：:Central nervous system (CNS) stem cells require epidermal growth factor (EGF) to survive and express glial-specific proteins (GSPs) under its influence. EGF and its receptor (EGF-R) therefore are involved in gliogenesis. We hypothesize that EGF selectively modulates GSP expression in pluripotential CNS cells and this ...

journal_title：Developmental neuroscience

authors： Shen YM,Meltzer H,Saljooque F,U HS

更新日期：2001-01-01 00:00:00

abstract：:Uncertainty reigns over whether or not glutamate uptake in astrocytes leads to strong stimulation of glucose utilization, measured as accumulation of radioactive deoxyglucose-6-phosphate. This is an important issue, not only because glutamate is the major excitatory transmitter, but also because it has been postulated...

journal_title：Developmental neuroscience

authors： Hertz L,Swanson RA,Newman GC,Marrif H,Juurlink BH,Peng L

更新日期：1998-01-01 00:00:00

abstract：:Cell polarity is one of the most basic properties of all normal cells and loss of polarity is a hallmark of cancer. While multiple proteins have been implicated in the maintenance of cell polarity, the functionally related neoplastic tumor suppressors Lethal giant larvae (Lgl), Scribble and Disks large comprise a uniq...

journal_title：Developmental neuroscience

authors： Vasioukhin V

更新日期：2006-01-01 00:00:00

abstract：:Three experimental approaches were used to examine the maturation of N-methyl-D-aspartate (NMDA) receptors in the neostriatum and compare their developmental profile to that of the non-NMDA receptors [alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and kainate (KA)]. The first, and least conventional ...

journal_title：Developmental neuroscience

authors： Colwell CS,Cepeda C,Crawford C,Levine MS

更新日期：1998-01-01 00:00:00

abstract：:In the development of an integrated approach to study metabolic compartmentation and regulation in brain, we have emphasized the importance, versatility, and need to exploit the recent methodological advances in (1) NMR spectroscopy, (2) primary cultures of neurons and glial cells, and (3) subcellular fractionation (e...

journal_title：Developmental neuroscience

authors： Lai JC,Behar KL

更新日期：1993-01-01 00:00:00

abstract：:The long noncoding RNA MSNP1AS (moesin pseudogene 1, antisense) is a functional element that was previously associated with autism spectrum disorder (ASD) with genome-wide significance. Expression of MSNP1AS was increased 12-fold in the cerebral cortex of individuals with ASD and 22-fold in individuals with a genome-w...

journal_title：Developmental neuroscience

authors： DeWitt JJ,Hecht PM,Grepo N,Wilkinson B,Evgrafov OV,Morris KV,Knowles JA,Campbell DB

更新日期：2016-01-01 00:00:00

abstract：:Prenatal cocaine exposure results in behavioral abnormalities throughout development in rats, but little is known regarding the biological mechanisms underlying these abnormalities. Pregnant rats received subcutaneous twice-daily injections (1 ml/kg) of normal saline or 15 mg/kg of cocaine hydrochloride throughout ges...

journal_title：Developmental neuroscience

authors： Johns JM,Lubin DA,Lieberman JA,Lauder JM

更新日期：2002-01-01 00:00:00

abstract：:This study investigated the time of expression of two endothelial cell adhesion molecules, ICAM-1/CD54 and PECAM-1/CD31 in the developing postpartum mouse blood-brain barrier (BBB). Immunoultrastructural studies demonstrated that both adhesion molecules are initially expressed primarily on the luminal endothelial cell...

journal_title：Developmental neuroscience

authors： Lossinsky AS,Wisniewski HM

更新日期：1998-01-01 00:00:00

abstract：:The kinetics and sodium-dependence of gamma-aminobutyric acid (GABA), hypotaurine and taurine uptake were analyzed in cerebral slices prepared from mice of different postnatal ages. The maximal velocities of transport (V) and the Km constants for the high-affinity uptake all decreased with age, whereas the development...

journal_title：Developmental neuroscience

authors： Oja SS,Kontro P

更新日期：1983-01-01 00:00:00

abstract：:L-Ornithine decarboxylase (ODC), the rate-limiting enzyme of polyamine biosynthesis and thus a unique marker of the proliferation and maturation processes, has been localized by means of immunohistochemistry in the human central nervous system. The enzyme protein has not only been found in the developing nervous syste...

journal_title：Developmental neuroscience

authors： Müller M,Pajunen AE,Järvinen M,Poeggel G,Bernstein HG

更新日期：1993-01-01 00:00:00

abstract：:The neonatal brain appears to be selectively vulnerable to oxidative stress. Several potential mechanisms associated with altered reactive oxygen species metabolism would explain the increased susceptibility. They include increased accumulation of hydrogen peroxide with subsequent neurotoxicity. This enhanced neurotox...

journal_title：Developmental neuroscience

authors： Ferriero DM

更新日期：2001-01-01 00:00:00

abstract：:When cells from the cerebellum of late-gestation rats were grown at low density (50-100 cells/mm2) in a three-dimensional culture system, they rapidly expressed morphological and electrophysiological properties of neurons. Growth and differentiation of the population of solitary neurons as a whole was statistically as...

journal_title：Developmental neuroscience

authors： Coates PW,Fermini B,Strahlendorf JC,Strahlendorf HK

更新日期：1992-01-01 00:00:00

abstract：:In the era of therapeutic hypothermia, reliable preclinical studies are integral to successfully identify neuroprotective strategies to further improve outcomes of encephalopathy at term. We reviewed preclinical neuroprotection studies reported between January 2014 and June 2016 to assess the use of effective temperat...

journal_title：Developmental neuroscience

authors： Galinsky R,Dean JM,Lear CA,Davidson JO,Dhillon S,Wassink G,Bennet L,Gunn AJ

更新日期：2017-01-01 00:00:00

abstract：:We have shown that the developmentally regulated appearance of the two myelin-associated glycoprotein (MAG) polypeptides in normal mouse brain myelin does not reflect the developmental pattern of differential splicing of primary gene transcripts as determined earlier by RNase protection assays. Contrary to expectation...

journal_title：Developmental neuroscience

authors： Braun PE,Horvàth E,Edwards AM

更新日期：1990-01-01 00:00:00

abstract：:The Notch signaling pathway is important at several stages of retinal development including the differentiation of retinal ganglion cells and Muller glia. The downstream effectors of Notch signaling, Hes1 and Hes5, have been shown to be critical in the retina as well. While Notch activity directly regulates Hes1 and H...

journal_title：Developmental neuroscience

authors： Nelson BR,Gumuscu B,Hartman BH,Reh TA

更新日期：2006-01-01 00:00:00

abstract：:Neural stem cells are attracting enormous attention in regenerative medicine due to their ability to self-renew and differentiate into the cell lineages that constitute the central nervous system. However, little is known about the mechanism underlying the regulation of their redox environment, which is essential for ...

journal_title：Developmental neuroscience

authors： Sharma N,Moore L,Chidambaram S,Colangelo NW,de Toledo SM,Azzam EI

更新日期：2018-01-01 00:00:00

abstract：:As a step toward using two closely related members of the nuclear receptor family, RORalpha and RORbeta, as markers and tools for genetic manipulations in mouse forebrain, we have used in situ hybridization to analyze their expression from E10.5 to P7. At later embryonic and early postnatal ages, RORalpha expression i...

journal_title：Developmental neuroscience

authors： Nakagawa Y,O'Leary DD

更新日期：2003-03-01 00:00:00

abstract：:In some cells, the development of voltage-gated channels requires synaptic input, while in others it does not. Here we investigate whether the sodium and potassium currents in the skeletal muscle of zebrafish sofa potato (sop(-/-)) mutants develop normally. Zebrafish sop(-/-) mutants do not express nicotinic acetylcho...

journal_title：Developmental neuroscience

authors： Coutts CA,Cunningham ME,Ali DW

更新日期：2009-01-01 00:00:00

abstract：:The auditory system of the cricket has the unusual ability to respond to deafferentation by compensatory growth and synapse formation. Auditory interneurons such as ascending neuron 2 (AN-2) in the cricket Gryllus bimaculatus possess a dendritic arbor that normally grows up to, but not over, the midline of the prothor...

journal_title：Developmental neuroscience

authors： Horch HW,Sheldon E,Cutting CC,Williams CR,Riker DM,Peckler HR,Sangal RB

更新日期：2011-01-01 00:00:00

abstract：:Neonatal stroke leads to mortality and severe morbidity, but there is no effective treatment currently available. Erythropoietin (EPO) has been shown to promote cytoprotection and neurogenesis and decrease subventricular zone morphologic changes following brain injury. The long-term cellular response to EPO has not be...

journal_title：Developmental neuroscience

authors： Gonzalez FF,McQuillen P,Mu D,Chang Y,Wendland M,Vexler Z,Ferriero DM

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Therapeutic hypothermia provides incomplete neuroprotection for neonatal hypoxic-ischemic encephalopathy (HIE). We examined whether hemodynamic goals that support autoregulation are associated with decreased brain injury and whether these relationships are affected by birth asphyxia or vary by anatomic regio...

journal_title：Developmental neuroscience

authors： Lee JK,Poretti A,Perin J,Huisman TAGM,Parkinson C,Chavez-Valdez R,O'Connor M,Reyes M,Armstrong J,Jennings JM,Gilmore MM,Koehler RC,Northington FJ,Tekes A

更新日期：2017-01-01 00:00:00