Abstract:
:Neonatal stroke leads to mortality and severe morbidity, but there is no effective treatment currently available. Erythropoietin (EPO) has been shown to promote cytoprotection and neurogenesis and decrease subventricular zone morphologic changes following brain injury. The long-term cellular response to EPO has not been defined, and local changes in cell fate decision may play a role in functional improvement. We performed middle cerebral artery occlusion in P10 rats. EPO treatment (5 U/g i.p.) significantly preserved hemispheric brain volume 6 weeks after injury. Furthermore, EPO increased the percentage of newly generated neurons while decreasing newly generated astrocytes following brain injury, without demonstrating long-term differences in the subventricular zone. These results suggest that EPO may neuroprotect and direct cell fate toward neurogenesis and away from gliogenesis in neonatal stroke.
journal_name
Dev Neuroscijournal_title
Developmental neuroscienceauthors
Gonzalez FF,McQuillen P,Mu D,Chang Y,Wendland M,Vexler Z,Ferriero DMdoi
10.1159/000105473subject
Has Abstractpub_date
2007-01-01 00:00:00pages
321-30issue
4-5eissn
0378-5866issn
1421-9859pii
000105473journal_volume
29pub_type
杂志文章abstract::Excitotoxicity plays a key role during insults to the developing brain such as neonatal encephalopathy, stroke, and encephalopathy of prematurity. Such insults affect many thousands of infants each year. Excitotoxicity causes frank lesions due to cell death and gliosis and disturbs normal developmental process, leadin...
journal_title:Developmental neuroscience
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journal_title:Developmental neuroscience
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更新日期:1990-01-01 00:00:00
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更新日期:2010-03-01 00:00:00
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doi:10.1159/000112744
更新日期:1981-01-01 00:00:00
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journal_title:Developmental neuroscience
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