Abstract:
:Rats were exposed to mild hyperoxia and hypoxia by the administration of oxygen/air and nitrogen/air mixtures through plastic tubing held close to their snouts for periods of 3 min. Changes in tissue oxygen were monitored at an implanted carbon paste electrode; local cerebral blood flow (rCBF) at an implanted platinum electrode using the hydrogen clearance technique; extracellular brain glucose at an implanted glucose oxidase-based biosensor and changes in lactate were measured using microdialysis. The nitrogen/air mixture led to a decrease in tissue oxygen, an increase in rCBF, a decrease in extracellular glucose, and an increase in lactate. The oxygen/air mixture led to an increase in tissue oxygen and extracellular glucose but no change in lactate or rCBF. The effects in unanaesthetised rats were compared with those in rats given 350 mg/kg chloral hydrate. The increase in lactate was greater in unanaesthetised than anaesthetised rats. The results show a dissociation between changes in rCBF and extracellular glucose and suggest that changes in oxygen affect utilisation rather than supply of glucose to the extracellular compartment.
journal_name
Dev Neuroscijournal_title
Developmental neuroscienceauthors
Lowry JP,Demestre M,Fillenz Mdoi
10.1159/000017298subject
Has Abstractpub_date
1998-01-01 00:00:00pages
52-8issue
1eissn
0378-5866issn
1421-9859pii
dne20052journal_volume
20pub_type
杂志文章abstract::Autism spectrum disorder (ASD) comprises a group of neurodevelopmental disorders characterized by social deficits and stereotyped behaviors. While several theories have emerged, the pathogenesis of ASD remains unknown. Although studies report dopamine signaling abnormalities in autistic patients, a coherent dopamine h...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000478725
更新日期:2017-01-01 00:00:00
abstract::The metabolism of [1-13C]D-glucose by astrocytes, neurons and mixed astroglial/neuronal cultures derived from the striatum of fetal rats was studied using NMR. Metabolic activity was studied in resting and depolarized cells (55 mM K+), with dibutyryl cyclic-AMP added to the medium to promote cell differentiation, and ...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111346
更新日期:1993-01-01 00:00:00
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journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112140
更新日期:1991-01-01 00:00:00
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journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111442
更新日期:1996-01-01 00:00:00
abstract::Nitric oxide may serve as a retrograde messenger to refine or stabilize synapses in the developing nervous system. Whether this action is dependent upon glutamate and the N-methyl-D-aspartate receptor is not yet established. We have used the patch-cluster system in the intermediate gray layer (IGL) of the rat superior...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111215
更新日期:1997-01-01 00:00:00
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journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000362206
更新日期:2014-01-01 00:00:00
abstract::Schizophrenia is a chronic and debilitating mental illness characterized by a broad range of abnormal behaviors, including delusions and hallucinations, impaired cognitive function, as well as mood disturbances and social withdrawal. Due to the heterogeneous nature of the disease, the causes of schizophrenia are very ...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000346157
更新日期:2013-01-01 00:00:00
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journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000096222
更新日期:2007-01-01 00:00:00
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journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000330321
更新日期:2011-01-01 00:00:00
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journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000437302
更新日期:2015-01-01 00:00:00
abstract::In vertebrate species, the neuropeptide oxytocin (OT) has been implicated in neural and behavioral development. Although several OT-like peptides have been characterized in invertebrate species, the ontogenesis of the OT-like system has not yet been described in these species. Thus, the aim of the present study was to...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000235942
更新日期:2010-03-01 00:00:00
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journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000082137
更新日期:2004-03-01 00:00:00
abstract::Previous studies have demonstrated that exposure to ethanol during development delays the rate at which axons in certain central nervous system tracts acquire myelin. This delay appears to be related to an alteration in oligodendrocyte function and not to an aberrancy in axon size or number. The present study was desi...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112154
更新日期:1991-01-01 00:00:00
abstract::The spontaneously immortalized S16 Schwann cell line expresses higher levels of myelin-associated glycoprotein (MAG) and PO glycoprotein and their messenger RNAs when grown at high density than at low density [Sasagasako et al: J Neurochem 1996;66:1432-1439]. This up-regulation of myelin protein expression at high den...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000017409
更新日期:1999-01-01 00:00:00
abstract::There is pressing need to employ new advances in structural MR brain imaging to better diagnose brain damage in newborn infants. Timely application of such technology will enable improved therapeutic interventions. Diffusion-weighted sequences are a sensitive marker of very early neuronal injury, the spatial pattern o...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000085988
更新日期:2005-03-01 00:00:00
abstract::Adult neuronal ceroid lipofuscinosis (NCL), also called Kufs' disease, is clinically distinct from the other NCLs. It is a rare condition which is difficult to diagnose. More than 50% of the reported cases of Kufs' disease are not adult NCL and correspond very likely to a heterogeneous spectrum of lipidoses. Various c...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000112182
更新日期:1991-01-01 00:00:00
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journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111276
更新日期:1995-01-01 00:00:00
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journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000504960
更新日期:2019-01-01 00:00:00
abstract::We report on the effects of etiology and age on the linguistic outcomes in a large pediatric hemispherectomy population. Four populations were considered separately: cortical dysplasia (multilobar involvement), Rasmussen's encephalitis, infarction as a primary etiology and, fourth, children who failed to develop langu...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000017396
更新日期:1999-11-01 00:00:00
abstract::Birth asphyxia can result in sensory impairment, learning and memory deficits without gross brain injury and severe motor deficits. We developed a model of birth asphyxia resulting in mild neurological injury and cognitive impairment using a long-gestation species with precocial fetal development. Spiny mice (Acomys c...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000251907
更新日期:2009-01-01 00:00:00
abstract::The distribution of the noradrenergic system within the rat cerebellar cortex following low-level X-irradiation was studied using tyrosine hydroxylase immunocytochemistry. X-Irradiation treatments consisted of 1, 3, or 5 successive daily dose beginning on postnatal day 1. When studied 24 h after the last exposure, a d...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112092
更新日期:1994-01-01 00:00:00
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journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112145
更新日期:1991-01-01 00:00:00
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journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112339
更新日期:1983-01-01 00:00:00
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journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000321342
更新日期:2010-01-01 00:00:00
abstract::Evidence from retroviral marking techniques and immortalized cell lines indicates that multipotential stem cells exist in many areas of the developing central nervous system. However, the factors that influence the commitment of these stem cells into distinct neuronal or glial lineages are not known. We have created a...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111301
更新日期:1995-01-01 00:00:00
abstract::We studied the developmental changes of soluble and membrane-bound protein kinases (EC 2.7.1.37) in rat brain and found that the elution profiles from a DEAE-cellulose column by NaCl of adenosine-3':5'-monophosphate (cyclic AMP) dependent protein kinase from cytosol were not significantly different in newborn (0.19 M ...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112450
更新日期:1979-01-01 00:00:00
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journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112377
更新日期:1980-01-01 00:00:00
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journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000343143
更新日期:2012-01-01 00:00:00
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journal_title:Developmental neuroscience
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pub_type: 杂志文章
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更新日期:1990-01-01 00:00:00