Abstract:
:Several studies have shown that exogenous gangliosides can stimulate neurite outgrowth (in vitro), accelerate peripheral nerve regeneration (in vivo) and facilitate CNS recovery after lesioning. Experiments were designed to assess the effects of ganglioside administration on neonatal development. Rat neonates received daily subcutaneous injections of gangliosides from PN day 5 through 15. Learning behavior (acquisition and retention) was facilitated in rats which had received injections of either total, GM1 or GD1b ganglioside. Rats injected with GD1a and GT1b ganglioside were not different from controls. Levels of total AChE activity as well as its 4s and 10s molecular forms in cortex, were assayed at PN days 9, 14, 21 and 28 in rats injected with GM1 ganglioside. These animals had consistently higher levels of enzyme activity as compared to saline controls. It is hypothesized that exogenous gangliosides accelerate CNS maturation.
journal_name
Dev Neuroscijournal_title
Developmental neuroscienceauthors
Karpiak SE,Vilim F,Mahadik SPdoi
10.1159/000112339subject
Has Abstractpub_date
1983-01-01 00:00:00pages
127-35issue
2eissn
0378-5866issn
1421-9859journal_volume
6pub_type
杂志文章abstract::Primary cultures of cerebellum from 5-day-old rats indicated that proliferating neuroblasts synthesize and release nerve growth factor (NGF). Since NGF promotes DNA synthesis in these cells, our findings demonstrate that the early developing cerebellum is a suitable physiological model for studying the autocrine mitog...
journal_title:Developmental neuroscience
pub_type: 杂志文章
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更新日期:1990-01-01 00:00:00
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更新日期:2009-01-01 00:00:00
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更新日期:1991-01-01 00:00:00
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更新日期:2001-01-01 00:00:00
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更新日期:2017-01-01 00:00:00
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journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000017298
更新日期:1998-01-01 00:00:00
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journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000017386
更新日期:1999-11-01 00:00:00
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journal_title:Developmental neuroscience
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journal_title:Developmental neuroscience
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更新日期:2002-01-01 00:00:00
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更新日期:1998-01-01 00:00:00
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更新日期:2002-01-01 00:00:00
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