Abstract:
:The neurochemical effect of postnatal exposure to methadone (METH), undernutrition (UND), and methadone and undernutrition (METH-UND) on the whole brain and cerebellum were examined in 21- and 60-day-old rats. At 21 days, body weight reductions of UND and METH-UND rats exceeded that of the METH animals. However, METH rats had the most severe deficits in the weight and total DNA content of the brain and cerebellum, as well as in brain DNA concentration. All experimental rats were subnormal in body weight at 60 days, as was the brain weight of METH-UND rats. Total brain DNA content was most reduced in 60-day-old METH animals, whereas brain RNA content and cerebellar DNA content was only lower in UND and METH-UND animals. These results suggest that methadone often has a greater retarding effect on whole brain and cerebellar development than would be expected by reduced caloric intake alone, and that at least part of the growth inhibiting effects of this drug originates from nonnutritional causes.
journal_name
Dev Neuroscijournal_title
Developmental neuroscienceauthors
Zagon IS,McLaughlin PJdoi
10.1159/000112698subject
Has Abstractpub_date
1982-01-01 00:00:00pages
385-93issue
5-6eissn
0378-5866issn
1421-9859journal_volume
5pub_type
杂志文章abstract::We have shown that the developmentally regulated appearance of the two myelin-associated glycoprotein (MAG) polypeptides in normal mouse brain myelin does not reflect the developmental pattern of differential splicing of primary gene transcripts as determined earlier by RNase protection assays. Contrary to expectation...
journal_title:Developmental neuroscience
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journal_title:Developmental neuroscience
pub_type: 杂志文章
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更新日期:1981-01-01 00:00:00
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更新日期:1988-01-01 00:00:00
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journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112759
更新日期:1981-01-01 00:00:00
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