A regional study of the molecular forms of acetylcholinesterase in the brain of developing and adult rats.

abstract：:The fine structure of pituicytes was investigated between 15 days of fetal life and 120 days postnatum. Prior to the penetration of neurosecretory axons into the neural lobe a uniform population of undifferentiated pituicytes is presented. Coincidental with the first appearance of neurosecretory axons in the neural lo...

journal_title：Developmental neuroscience

authors： Dellmann HD,Sikora K

更新日期：1981-01-01 00:00:00

abstract：:The neurochemical effect of postnatal exposure to methadone (METH), undernutrition (UND), and methadone and undernutrition (METH-UND) on the whole brain and cerebellum were examined in 21- and 60-day-old rats. At 21 days, body weight reductions of UND and METH-UND rats exceeded that of the METH animals. However, METH ...

journal_title：Developmental neuroscience

authors： Zagon IS,McLaughlin PJ

更新日期：1982-01-01 00:00:00

abstract：:Neurotransmitters play important roles in neurogenesis; in particular, acetylcholine and serotonin may regulate neurite elongation. Acetylcholine may also activate transcription factors such as early growth response protein 1 (EGR-1), which plays a role in neurite extension. N18TG2 neuroblastoma cells (which do not pr...

journal_title：Developmental neuroscience

authors： Anelli T,Cardarelli S,Ori M,Nardi I,Biagioni S,Poiana G

更新日期：2013-01-01 00:00:00

abstract：:Pediatric traumatic brain injury is a significant problem that affects many children each year. Progress is being made in developing neuroprotective strategies to combat these injuries. However, investigators are a long way from therapies to fully preserve injured neurons and glia. To restore neurological function, re...

journal_title：Developmental neuroscience

authors： Goodus MT,Guzman AM,Calderon F,Jiang Y,Levison SW

更新日期：2015-01-01 00:00:00

abstract：:We have used whole-cell and single-channel recording techniques to investigate the electrophysiological properties of cultured ovine oligodendrocytes (OLGs). Our studies have led to the following conclusions. (1) Cultured mature OLGs express a variety of voltage-dependent K+ conductances including an outward current t...

journal_title：Developmental neuroscience

authors： Soliven B,Szuchet S,Arnason BG,Nelson DJ

更新日期：1989-01-01 00:00:00

abstract：:Birth asphyxia can result in sensory impairment, learning and memory deficits without gross brain injury and severe motor deficits. We developed a model of birth asphyxia resulting in mild neurological injury and cognitive impairment using a long-gestation species with precocial fetal development. Spiny mice (Acomys c...

journal_title：Developmental neuroscience

authors： Hutton LC,Ratnayake U,Shields A,Walker DW

更新日期：2009-01-01 00:00:00

abstract：:Fragile X syndrome (FXS) is a neurodevelopmental disorder characterized by intellectual disability, sensory hypersensitivity, and high incidences of autism spectrum disorders and epilepsy. These phenotypes are suggestive of defects in neural circuit development and imbalances in excitatory glutamatergic and inhibitory...

journal_title：Developmental neuroscience

authors： Paluszkiewicz SM,Martin BS,Huntsman MM

更新日期：2011-01-01 00:00:00

abstract：:The rate of glutaminase-dependent metabolism of glutamine in intact astrocytes was determined under conditions in which the extracellular concentration of glutamine was varied between 0.2 and 3.2 mM glutamine for control and dibutyryl cyclic AMP (dBcAMP)-treated cells. Glutamine metabolism by intact cells increased wi...

journal_title：Developmental neuroscience

authors： Zielke HR,Tildon JT,Zielke CL

更新日期：1996-01-01 00:00:00

abstract：:We studied the developmental changes of soluble and membrane-bound protein kinases (EC 2.7.1.37) in rat brain and found that the elution profiles from a DEAE-cellulose column by NaCl of adenosine-3':5'-monophosphate (cyclic AMP) dependent protein kinase from cytosol were not significantly different in newborn (0.19 M ...

journal_title：Developmental neuroscience

authors： Kinnier WJ,Chikvaidze V,Hollenbeck RA,Chuang DM,Costa E

更新日期：1979-01-01 00:00:00

abstract：:The effects of hyperbaric exposure with high oxygen concentration on the physical activity of developing male rats were investigated. Five-week-old male rats were exposed to an atmospheric pressure of 1.25 with an oxygen concentration of 36.0% for 12 h (7.00-19.00 h) and exercised voluntarily for 12 h (19.00-7.00 h) d...

journal_title：Developmental neuroscience

authors： Matsumoto A,Okiura T,Morimatsu F,Ohira Y,Ishihara A

更新日期：2007-01-01 00:00:00

abstract：:It has been demonstrated that postweaning social isolation alters dendritic development in the medial prefrontal cortex (mPFC) of the rat. In addition, (-)-deprenyl, a monoamine oxidase B (MAO-B) inhibitor, promotes dendritic growth in prefrontocortical pyramidal cells. This study examined whether prefrontocortical de...

journal_title：Developmental neuroscience

authors： Pascual R,Zamora-León SP

更新日期：2007-01-01 00:00:00

abstract：:Using Western blot and immunocytochemistry to detect protein, and in situ hybridization and Northern blot to detect RNA, we studied the expression of Na,K-ATPase subunit isoforms in cultured astrocytes and oligodendrocytes in vitro, and in glial cells in the brain. We found that astrocytes in culture express alpha 1 a...

journal_title：Developmental neuroscience

authors： Fink D,Knapp PE,Mata M

更新日期：1996-01-01 00:00:00

abstract：:The spontaneously immortalized S16 Schwann cell line expresses higher levels of myelin-associated glycoprotein (MAG) and PO glycoprotein and their messenger RNAs when grown at high density than at low density [Sasagasako et al: J Neurochem 1996;66:1432-1439]. This up-regulation of myelin protein expression at high den...

journal_title：Developmental neuroscience

authors： Sasagasako N,Ohno M,Quarles RH

更新日期：1999-01-01 00:00:00

abstract：:The effect of undernutrition on the activity of glutamate decarboxylase (GAD) and choline acetyltransferase (ChAc) (markers for the GABA-ergic and the cholinergic transmitter system, respectively) was studied in various parts of the rat brain at the age of 10, 15 and 21 days, and at day 54 following 33 days of rehabil...

journal_title：Developmental neuroscience

authors： Patel AJ,del Vecchio M,Atkinson DJ

更新日期：1978-01-01 00:00:00

abstract：:In order to investigate the possible influence of norepinephrine (NE) on neuronal development, the effects of neonatal NE depletion on postnatally developing cell populations were characterized in (1) the normal mouse cerebellum, and (2) a cerebellar model system with delayed germinal cell development produced by neon...

journal_title：Developmental neuroscience

authors： Lovell KL

更新日期：1982-01-01 00:00:00

abstract：:The neonatal brain appears to be selectively vulnerable to oxidative stress. Several potential mechanisms associated with altered reactive oxygen species metabolism would explain the increased susceptibility. They include increased accumulation of hydrogen peroxide with subsequent neurotoxicity. This enhanced neurotox...

journal_title：Developmental neuroscience

authors： Ferriero DM

更新日期：2001-01-01 00:00:00

abstract：:Preterm birth is an important cause of perinatal brain injury (PBI). Neurological injury in extremely preterm infants often begins in utero with chorioamnionitis (CHORIO) or inflammation/infection of the placenta and concomitant placental insufficiency. Studies in humans have shown dysregulated inflammatory signaling ...

journal_title：Developmental neuroscience

authors： Yellowhair TR,Noor S,Mares B,Jose C,Newville JC,Maxwell JR,Northington FJ,Milligan ED,Robinson S,Jantzie LL

更新日期：2019-03-28 00:00:00

abstract：:The proximodistal axonal transport of choline acetyltransferase (ChAc) has been studied in the chick sciatic nerve in the absence of any experimental manipulation. The phenomenon utilized by us is a physiological transient fall in the activity of ChAc. This fall occurs in most areas of the chick central nervous system...

journal_title：Developmental neuroscience

authors： Giacobini G,Cannas M,Panattoni GL,Filogamo G

更新日期：1979-01-01 00:00:00

abstract：:Recent studies have shown a protection from cerebral hypoxic-ischemic (HI) brain damage in the immature rat following a prior systemic hypoxic exposure when compared with those not exposed previously. To investigate the mechanism(s) of hypoxic preconditioning, brain glycogen and high-energy phosphate reserves were mea...

journal_title：Developmental neuroscience

authors： Brucklacher RM,Vannucci RC,Vannucci SJ

更新日期：2002-01-01 00:00:00

abstract：:Nitric oxide may serve as a retrograde messenger to refine or stabilize synapses in the developing nervous system. Whether this action is dependent upon glutamate and the N-methyl-D-aspartate receptor is not yet established. We have used the patch-cluster system in the intermediate gray layer (IGL) of the rat superior...

journal_title：Developmental neuroscience

authors： Mize RR,Scheiner CA,Salvatore MF,Cork RJ

更新日期：1997-01-01 00:00:00

abstract：:Cell polarity is one of the most basic properties of all normal cells and loss of polarity is a hallmark of cancer. While multiple proteins have been implicated in the maintenance of cell polarity, the functionally related neoplastic tumor suppressors Lethal giant larvae (Lgl), Scribble and Disks large comprise a uniq...

journal_title：Developmental neuroscience

authors： Vasioukhin V

更新日期：2006-01-01 00:00:00

abstract：:Uncertainty reigns over whether or not glutamate uptake in astrocytes leads to strong stimulation of glucose utilization, measured as accumulation of radioactive deoxyglucose-6-phosphate. This is an important issue, not only because glutamate is the major excitatory transmitter, but also because it has been postulated...

journal_title：Developmental neuroscience

authors： Hertz L,Swanson RA,Newman GC,Marrif H,Juurlink BH,Peng L

更新日期：1998-01-01 00:00:00

abstract：:Apoptosis is a controlled form of cell death that participates in the demise of neuronal cells during development, neurodegenerative disorders and exposure to neurotoxic agents. In recent years, the mitochondria have emerged as being pivotal in controlling apoptosis. They house a number of apoptogenic molecules that a...

journal_title：Developmental neuroscience

authors： Gorman AM,Ceccatelli S,Orrenius S

更新日期：2000-09-01 00:00:00

abstract：:The M50 and M100 auditory evoked responses reflect early auditory processes in the primary/secondary auditory cortex. Although previous M50 and M100 studies have been conducted on individuals with autism spectrum disorder (ASD) and indicate disruption of encoding simple sensory information, analogous investigations of...

journal_title：Developmental neuroscience

authors： Matsuzaki J,Ku M,Dipiero M,Chiang T,Saby J,Blaskey L,Kuschner ES,Kim M,Berman JI,Bloy L,Chen YH,Dell J,Liu S,Brodkin ES,Embick D,Roberts TPL

更新日期：2019-01-01 00:00:00

abstract：:While extracellular signals play a major role in brain neurogenesis, little is known about the cell cycle machinery underlying mitogen stimulation of precursor proliferation. Current models suggest that the D cyclins function as primary sensors of extracellular mitogens. Here we define the mechanisms by which basic fi...

journal_title：Developmental neuroscience

authors： Li B,DiCicco-Bloom E

更新日期：2004-03-01 00:00:00

abstract：:Several studies have shown that exogenous gangliosides can stimulate neurite outgrowth (in vitro), accelerate peripheral nerve regeneration (in vivo) and facilitate CNS recovery after lesioning. Experiments were designed to assess the effects of ganglioside administration on neonatal development. Rat neonates received...

journal_title：Developmental neuroscience

authors： Karpiak SE,Vilim F,Mahadik SP

更新日期：1983-01-01 00:00:00

abstract：:There is an important unmet need to further improve the outcome of neonatal encephalopathy in term infants. Meta-analyses of large controlled trials now suggest that maternal magnesium sulfate (MgSO4) therapy is associated with a reduced risk of cerebral palsy and gross motor dysfunction after premature birth, but tha...

journal_title：Developmental neuroscience

authors： Galinsky R,Bennet L,Groenendaal F,Lear CA,Tan S,van Bel F,Juul SE,Robertson NJ,Mallard C,Gunn AJ

更新日期：2014-01-01 00:00:00

abstract：:Neural stem cells are attracting enormous attention in regenerative medicine due to their ability to self-renew and differentiate into the cell lineages that constitute the central nervous system. However, little is known about the mechanism underlying the regulation of their redox environment, which is essential for ...

journal_title：Developmental neuroscience

authors： Sharma N,Moore L,Chidambaram S,Colangelo NW,de Toledo SM,Azzam EI

更新日期：2018-01-01 00:00:00

abstract：:Chick embryo retina neurons in culture extend neurites and form synapses. Seven different culture substrates were compared to determine which culture surface would produce the best neuronal survival and neurite extension. The order of survival of retina neurons during 7 days of culture is salt-precipitated collagen gr...

journal_title：Developmental neuroscience

authors： Thompson JM,Pelto DJ

更新日期：1982-01-01 00:00:00

abstract：:In the socially monogamous prairie vole, we have observed that small changes in early handling, as well as early hormonal manipulations can have long-lasting and sexually dimorphic effects on behavior. These changes may be mediated in part by changes in parental interactions with their young, acting on systems that re...

journal_title：Developmental neuroscience

authors： Carter CS,Boone EM,Pournajafi-Nazarloo H,Bales KL

更新日期：2009-01-01 00:00:00