Abstract:
:The proximodistal axonal transport of choline acetyltransferase (ChAc) has been studied in the chick sciatic nerve in the absence of any experimental manipulation. The phenomenon utilized by us is a physiological transient fall in the activity of ChAc. This fall occurs in most areas of the chick central nervous system after hatching, and moves toward the periphery along the nerves. Having ruled out the presence of transient inhibitors, the movement of the fall towards skeletal muscles has been considered to correspond to the proximodistal transport of ChAc. The calculated average velocity is 7.86 mm/day, corresponding to the slow rate of transport. Nevertheless, the kinematics study suggests that the velocity varies along the nerve from a state of rest to an intermediate rate of transport (16 mm/day). The possible influence of variations in the resistance of the conductor on these changes in velocity is discussed.
journal_name
Dev Neuroscijournal_title
Developmental neuroscienceauthors
Giacobini G,Cannas M,Panattoni GL,Filogamo Gdoi
10.1159/000112484subject
Has Abstractpub_date
1979-01-01 00:00:00pages
225-34issue
5eissn
0378-5866issn
1421-9859journal_volume
2pub_type
杂志文章abstract::In the development of an integrated approach to study metabolic compartmentation and regulation in brain, we have emphasized the importance, versatility, and need to exploit the recent methodological advances in (1) NMR spectroscopy, (2) primary cultures of neurons and glial cells, and (3) subcellular fractionation (e...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000111334
更新日期:1993-01-01 00:00:00
abstract::The spontaneously immortalized S16 Schwann cell line expresses higher levels of myelin-associated glycoprotein (MAG) and PO glycoprotein and their messenger RNAs when grown at high density than at low density [Sasagasako et al: J Neurochem 1996;66:1432-1439]. This up-regulation of myelin protein expression at high den...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000017409
更新日期:1999-01-01 00:00:00
abstract::Cultures of rat oligodendrocytes were used to test the possible role of the cerebellar soluble lectin (CSL) in myelin formation. Immunocytochemistry at the ultrastructural level showed that the lectin is present in the cytoplasm of the perikaryon of cultured oligodendrocytes and also on the plasma membrane of the cell...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111970
更新日期:1988-01-01 00:00:00
abstract::Uncertainty reigns over whether or not glutamate uptake in astrocytes leads to strong stimulation of glucose utilization, measured as accumulation of radioactive deoxyglucose-6-phosphate. This is an important issue, not only because glutamate is the major excitatory transmitter, but also because it has been postulated...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000017329
更新日期:1998-01-01 00:00:00
abstract::As a step toward using two closely related members of the nuclear receptor family, RORalpha and RORbeta, as markers and tools for genetic manipulations in mouse forebrain, we have used in situ hybridization to analyze their expression from E10.5 to P7. At later embryonic and early postnatal ages, RORalpha expression i...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000072271
更新日期:2003-03-01 00:00:00
abstract::Stromal-derived factor 1 (SDF-1), a known chemoattractant, and its receptor CXCR4 are widely expressed in the developing and adult cerebral cortex. Recent studies have highlighted potential roles for SDF-1 during early cortical development. In view of the current findings, our histological analysis has revealed a dist...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000109857
更新日期:2008-01-01 00:00:00
abstract::In this study, the proliferative activity of cultured chick neuroblasts exposed to high or low concentrations of fetal calf serum (FCS) was investigated. Different experimental evidences showed that the first 2-3 days of culture correspond to a period of neuronal proliferation in our culture conditions, whereas contam...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112344
更新日期:1983-01-01 00:00:00
abstract::Maternal inflammation has been linked to neurodevelopmental and neuropsychiatric disorders such as cerebral palsy, schizophrenia, and autism. We had previously shown that intrauterine inflammation resulted in a decrease in serotonin, one of the tryptophan metabolites, and a decrease in serotonin fibers in the sensory ...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000471509
更新日期:2017-01-01 00:00:00
abstract::Perinatal hypoxic ischemic (HI) brain injury is a leading cause of long-term neurological handicap in newborn babies. Recently, excessive activity of matrix metalloproteinases (MMPs), and in particular MMP-9, has been implicated in the aetiology of HI injuries to the immature brain. Our previous study suggested that M...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000343257
更新日期:2012-01-01 00:00:00
abstract::Dissociated cells of cerebral hemispheres from 8-day-old chick embryos were cultivated for 8 days in polylysine-coated Petri dishes. Changes of DNA, RNA, total proteins, putrescine, spermidine, spermine, free amino acids and enzymes involved in polyamine and GABA metabolism were studied throughout neuronal development...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112755
更新日期:1981-01-01 00:00:00
abstract::The myelin-associated glycoprotein (MAG) is a 100 K-dalton, integral membrane glycoprotein containing 30% carbohydrate that is in central and peripheral myelin sheaths. Recent research on its function during normal myelinogenesis and possible roles in the pathology of demyelinating diseases is reviewed. Emphasis is pl...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000112356
更新日期:1983-01-01 00:00:00
abstract::We have previously provided evidence that ferritin binds selectively to white matter tracts in adult mouse and human brains. In cell culture experiments, ferritin binding is specifically localized to oligodendrocytes. The goal of the present study is to test the hypothesis that the developmental pattern for ferritin b...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000065704
更新日期:2002-01-01 00:00:00
abstract::Developmental expression of neutral monoglycosylceramides (MGCs) has been examined in rat brain from embryonic day 15 (E15) to postnatal day 30 (P30) and adulthood. To this point, glucosylceramide (GlcCer) is the only MGC that has been characterized in embryonic brain. Galactosylceramide (GalCer) appears at P1, increa...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111201
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Therapeutic hypothermia provides incomplete neuroprotection for neonatal hypoxic-ischemic encephalopathy (HIE). We examined whether hemodynamic goals that support autoregulation are associated with decreased brain injury and whether these relationships are affected by birth asphyxia or vary by anatomic regio...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000452833
更新日期:2017-01-01 00:00:00
abstract::All known actions of cAMP in the brain require cAMP-dependent protein kinase (cAMPdPK), which consists of regulatory (R) and catalytic (C) subunits (R2C2). Using homologous rat cDNAs for all known cAMPdPK subunit isoforms found in the brain (RI alpha, RI beta, RII alpha, RII beta, C alpha, C beta) we observe that, in ...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112140
更新日期:1991-01-01 00:00:00
abstract::Metabolism of glutamate and glutamine in cultured mouse cerebral cortical astrocytes has been investigated using either radioactively labelled (14C) amino acids or 13C-labelled amino acids combined with NMR spectroscopy of cell extracts and lyophilyzed incubation media. Using [U-13C]glutamate it has been shown that in...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000111356
更新日期:1993-01-01 00:00:00
abstract::It has been demonstrated that postweaning social isolation alters dendritic development in the medial prefrontal cortex (mPFC) of the rat. In addition, (-)-deprenyl, a monoamine oxidase B (MAO-B) inhibitor, promotes dendritic growth in prefrontocortical pyramidal cells. This study examined whether prefrontocortical de...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000096413
更新日期:2007-01-01 00:00:00
abstract::We have previously reported that a developmental axon-sparing striatal injury induced by hypoxia-ischemia results in a diminished adult number of substantia nigra (SN) tyrosine hydroxylase (TH)-positive neurons, in the absence of direct nigral injury. To examine the specific role of striatal injury, we made selective ...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111684
更新日期:1992-01-01 00:00:00
abstract::Insulin binding was measured on crude mitochondrial or plasma membranes prepared from different rat brain regions during postnatal development. In the cerebral cortex and brainstem, insulin binding decreased 60-70% between birth and the adult period. In the cerebellum, insulin binding doubled in the first 10 postnatal...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111863
更新日期:1990-01-01 00:00:00
abstract::We investigated the effects of perinatal hypoxia-ischemia (HI) on brain injury and neurological functional outcome at postnatal day (P)30 through P90. HI was induced by exposing P9 mice to 8% O(2) for 55 min using the Vannucci HI model. Following HI, mice were treated with either vehicle control or Na(+)/H(+) exchange...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000328430
更新日期:2011-01-01 00:00:00
abstract::The neurochemical effect of postnatal exposure to methadone (METH), undernutrition (UND), and methadone and undernutrition (METH-UND) on the whole brain and cerebellum were examined in 21- and 60-day-old rats. At 21 days, body weight reductions of UND and METH-UND rats exceeded that of the METH animals. However, METH ...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112698
更新日期:1982-01-01 00:00:00
abstract::To define the effects of neurotrophins on oligodendrocytes, we monitored NGF, BDNF and NT-3 actions on basal forebrain (BF) and cortical populations. NGF, BDNF and NT-3 applied to BF oligodendrocytes elicited increases in expression of myelin basic protein (MBP) and enhanced the numbers of MBP+ cells, without affectin...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000072261
更新日期:2003-03-01 00:00:00
abstract::Perinatal asphyxia is a leading cause of brain injury in neonates, occurring in 2-4 per 1,000 live births, and there are limited treatment options. Because of their similarity to humans, nonhuman primates are ideal for performing preclinical tests of safety and efficacy for neurotherapeutic interventions. We previousl...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000327246
更新日期:2011-01-01 00:00:00
abstract::Adrenoleukodystrophy (ALD) is an X-linked recessive disorder that affects mainly the nervous system white matter and the adrenal cortex. It is associated with an abnormal accumulation of saturated very long chain fatty acids and can be diagnosed by demonstrating an excess of these substances in plasma or red cells. Ou...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000112170
更新日期:1991-01-01 00:00:00
abstract::The postnatal developmental expression and the distribution of the glutamate transporters (GLAST, GLT-1 and EAAC1) were analyzed in rat vestibular nuclei (VN), at birth and during the following 4 weeks. Analyses were performed using reverse transcriptase-polymerase chain reaction and immunoblotting of GLAST, GLT-1 and...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000073510
更新日期:2003-09-01 00:00:00
abstract::Neurotoxicological studies have indicated that L-glutamate exhibits more pronounced effects on the preoptic area (POA) neurons of male rats than on those of females in the neonatal period. However, no information has previously been available as to whether or not such sexual dimorphism also exists for the effects of g...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000048726
更新日期:2001-01-01 00:00:00
abstract::Various abnormalities in frontal and striatal regions have been reported in children with prenatal alcohol and/or methamphetamine exposure. In a recent fMRI study, we observed a correlation between accuracy on a working-memory task and functional activation in the putamen in children with prenatal methamphetamine and ...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000336242
更新日期:2012-01-01 00:00:00
abstract::Cortex cerebri pieces from fetal donors were homologously and bilaterally grafted to the anterior eye chamber of adult albino rats. After intraocular maturation, presence of an external glial membrane, glial membranes surrounding blood vessels and cortical astrocytes was demonstrated using antisera raised against glia...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112703
更新日期:1982-01-01 00:00:00
abstract::Previous studies have demonstrated that exposure to ethanol during development delays the rate at which axons in certain central nervous system tracts acquire myelin. This delay appears to be related to an alteration in oligodendrocyte function and not to an aberrancy in axon size or number. The present study was desi...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112154
更新日期:1991-01-01 00:00:00
abstract::Apoptosis is a controlled form of cell death that participates in the demise of neuronal cells during development, neurodegenerative disorders and exposure to neurotoxic agents. In recent years, the mitochondria have emerged as being pivotal in controlling apoptosis. They house a number of apoptogenic molecules that a...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000017460
更新日期:2000-09-01 00:00:00