Abstract:
:To define the effects of neurotrophins on oligodendrocytes, we monitored NGF, BDNF and NT-3 actions on basal forebrain (BF) and cortical populations. NGF, BDNF and NT-3 applied to BF oligodendrocytes elicited increases in expression of myelin basic protein (MBP) and enhanced the numbers of MBP+ cells, without affecting total cell numbers. In the cortex, however, while NGF and NT-3 influenced MBP expression, BDNF was without effect. To explore this apparent regional difference in BDNF action, we compared expression of the neurotrophin receptors trkA, trkB and trkC. While BF cells expressed all three trks, cortical cells did not express the full-length BDNF receptor, trkB. Interestingly, in no case was any receptor expressed by all oligodendrocytes, indicating that oligodendrocytes may be heterogeneous within a brain region. The data suggest that BF oligodendrocytes are influenced by BDNF to express MBP and are distinct in this ability from cortical cells.
journal_name
Dev Neuroscijournal_title
Developmental neuroscienceauthors
Du Y,Fischer TZ,Lee LN,Lercher LD,Dreyfus CFdoi
10.1159/000072261keywords:
subject
Has Abstractpub_date
2003-03-01 00:00:00pages
116-26issue
2-4eissn
0378-5866issn
1421-9859pii
72261journal_volume
25pub_type
杂志文章abstract::We report on the effects of etiology and age on the linguistic outcomes in a large pediatric hemispherectomy population. Four populations were considered separately: cortical dysplasia (multilobar involvement), Rasmussen's encephalitis, infarction as a primary etiology and, fourth, children who failed to develop langu...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000017396
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journal_title:Developmental neuroscience
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journal_title:Developmental neuroscience
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doi:10.1159/000235942
更新日期:2010-03-01 00:00:00
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doi:10.1159/000065691
更新日期:2002-01-01 00:00:00
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journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000096212
更新日期:2007-01-01 00:00:00
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journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000017364
更新日期:1999-01-01 00:00:00
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journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000496200
更新日期:2019-03-12 00:00:00
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更新日期:2011-01-01 00:00:00
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journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000112182
更新日期:1991-01-01 00:00:00
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journal_title:Developmental neuroscience
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更新日期:1999-11-01 00:00:00
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更新日期:1982-01-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:1997-01-01 00:00:00
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journal_title:Developmental neuroscience
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pub_type: 杂志文章,评审
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更新日期:2009-01-01 00:00:00