Zinc status of human IMR-32 neuroblastoma cells influences their susceptibility to iron-induced oxidative stress.

abstract：:Maternal inflammation has been linked to neurodevelopmental and neuropsychiatric disorders such as cerebral palsy, schizophrenia, and autism. We had previously shown that intrauterine inflammation resulted in a decrease in serotonin, one of the tryptophan metabolites, and a decrease in serotonin fibers in the sensory ...

journal_title：Developmental neuroscience

authors： Williams M,Zhang Z,Nance E,Drewes JL,Lesniak WG,Singh S,Chugani DC,Rangaramanujam K,Graham DR,Kannan S

更新日期：2017-01-01 00:00:00

abstract：:The myelin-associated glycoprotein (MAG) is a 100 K-dalton, integral membrane glycoprotein containing 30% carbohydrate that is in central and peripheral myelin sheaths. Recent research on its function during normal myelinogenesis and possible roles in the pathology of demyelinating diseases is reviewed. Emphasis is pl...

journal_title：Developmental neuroscience

authors： Quarles RH

更新日期：1983-01-01 00:00:00

abstract：:Recent studies have shown a protection from cerebral hypoxic-ischemic (HI) brain damage in the immature rat following a prior systemic hypoxic exposure when compared with those not exposed previously. To investigate the mechanism(s) of hypoxic preconditioning, brain glycogen and high-energy phosphate reserves were mea...

journal_title：Developmental neuroscience

authors： Brucklacher RM,Vannucci RC,Vannucci SJ

更新日期：2002-01-01 00:00:00

abstract：:Neuron-specific enolase (NSE) is a unique form of the glycolytic enzyme, enolase, which, in the brain, is strictly localized in differentiated neurons and neuroendocrine cells. In this report evidence is presented that NSE is first seen in the cell bodies of developing chick auditory and vestibular neurons shortly aft...

journal_title：Developmental neuroscience

authors： Whitehead MC,Marangos PJ,Connolly SM,Morest DK

更新日期：1982-01-01 00:00:00

abstract：:Nogo is a member of the reticulon family. Our understanding of the physiological functions of the Nogo-A protein has grown over the last few years, and this molecule is now recognized as one of the most important axonal regrowth inhibitors present in central nervous system (CNS) myelin. Nogo-A plays other important ro...

journal_title：Developmental neuroscience

authors： Haybaeck J,Llenos IC,Dulay RJ,Bettermann K,Miller CL,Wälchli T,Frei K,Virgintino D,Rizzi M,Weis S

更新日期：2012-01-01 00:00:00

abstract：:Traumatic brain injury (TBI) is predominantly a clinical problem of young persons, resulting in chronic cognitive and behavioral deficits. Specifically, the physiological response to a diffuse biomechanical injury in a maturing brain can clearly alter normal neuroplasticity. To properly evaluate and investigate develo...

journal_title：Developmental neuroscience

authors： Giza CC,Prins ML

更新日期：2006-01-01 00:00:00

abstract：:Radiotherapy is an effective treatment strategy in the treatment of brain tumors, but it is also a major cause of long-term complications, especially in survivors of pediatric brain tumors. Cognitive decline caused by cranial radiotherapy is thought, at least partly, to depend on injury to stem and progenitor cells in...

journal_title：Developmental neuroscience

authors： Roughton K,Andreasson U,Blomgren K,Kalm M

更新日期：2013-01-01 00:00:00

abstract：:In the presence of nerve growth factor (NGF) PC12 pheochromocytoma cells develop properties of sympathetic neurons and extend long microtubule-containing neurites. PC12 cell microtubule protein was isolated using an assembly and disassembly procedure, either directly from an unlabeled cell extract or by copolymerizati...

journal_title：Developmental neuroscience

authors： Richter-Landsberg C,Landreth GE,Shooter EM

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:Neonatal hypoxic-ischemic (HI) encephalopathy occurs in 1-4 per 1,000 live term births and can cause devastating neurodevelopmental disabilities. Currently, therapeutic hypothermia (TH) is the only treatment with proven efficacy. Since TH is associated with decreased cerebral metabolism and cerebral blood fl...

journal_title：Developmental neuroscience

authors： Buckley EM,Patel SD,Miller BF,Franceschini MA,Vannucci SJ

更新日期：2015-01-01 00:00:00

abstract：:Proper eye formation depends on specific interactions between neural and ectodermal tissues coupled with temporally distinct gene expression and a regulated sequence of signaling events. The homeobox gene Pax6 is vitally important to the entire process of eye development in both vertebrates and invertebrates. Pax6 exp...

journal_title：Developmental neuroscience

authors： Reza HM,Yasuda K

更新日期：2004-01-01 00:00:00

abstract：:Glutamine synthesis, the major pathway of ammonia detoxification, and the intracellular concentration of organic osmolytes in primary astrocytes and F98 glioma cells were investigated with multinuclear magnetic resonance spectroscopy. Acute exposure to ammonia (3 h incubation with NH4Cl) raised the concentration of gl...

journal_title：Developmental neuroscience

authors： Zwingmann C,Brand A,Richter-Landsberg C,Leibfritz D

更新日期：1998-01-01 00:00:00

abstract：:Oligodendrocyte precursor cells (OPCs) originate in multiple restricted regions of the developing central nervous system (CNS). Here, we focus on morphological changes of oligodendrocyte lineage cells and their cellular dynamics including cell motility and proliferation. Morphological studies with molecular markers fo...

journal_title：Developmental neuroscience

authors： Ono K,Kagawa T,Tsumori T,Yokota S,Yasui Y

更新日期：2001-01-01 00:00:00

abstract：:Perinatal asphyxia is a leading cause of brain injury in neonates, occurring in 2-4 per 1,000 live births, and there are limited treatment options. Because of their similarity to humans, nonhuman primates are ideal for performing preclinical tests of safety and efficacy for neurotherapeutic interventions. We previousl...

journal_title：Developmental neuroscience

authors： Jacobson Misbe EN,Richards TL,McPherson RJ,Burbacher TM,Juul SE

更新日期：2011-01-01 00:00:00

abstract：:This study of the molecular forms of acetylcholinesterase in several rat brain regions using sucrose gradient centrifugation has revealed only two major forms throughout postnatal development: the 4S and 10S. In all regions studied (cerebral cortex, cerebellum, caudate nucleus, hippocampus, pons-medulla and superior c...

journal_title：Developmental neuroscience

authors： Wade PD,Timiras PS

更新日期：1980-01-01 00:00:00

abstract：:The norepinephrine content of hypothalamus in vehicle-treated control rats gradually increases between days 16 and 45 of life. Norepinephrine contents of the hypothalamus and mesencephalon of the thyroxine-treated (10 microgram/g b.w., s.c., days 8-10) animals also increase between days 16 and 21. Mesencephalic and hy...

journal_title：Developmental neuroscience

authors： Lengvári I,Branch BJ,Taylor AN

更新日期：1980-01-01 00:00:00

abstract：:Using Western blot and immunocytochemistry to detect protein, and in situ hybridization and Northern blot to detect RNA, we studied the expression of Na,K-ATPase subunit isoforms in cultured astrocytes and oligodendrocytes in vitro, and in glial cells in the brain. We found that astrocytes in culture express alpha 1 a...

journal_title：Developmental neuroscience

authors： Fink D,Knapp PE,Mata M

更新日期：1996-01-01 00:00:00

abstract：:Birth asphyxia can result in sensory impairment, learning and memory deficits without gross brain injury and severe motor deficits. We developed a model of birth asphyxia resulting in mild neurological injury and cognitive impairment using a long-gestation species with precocial fetal development. Spiny mice (Acomys c...

journal_title：Developmental neuroscience

authors： Hutton LC,Ratnayake U,Shields A,Walker DW

更新日期：2009-01-01 00:00:00

abstract：:Autism spectrum disorder (ASD) comprises a group of neurodevelopmental disorders characterized by social deficits and stereotyped behaviors. While several theories have emerged, the pathogenesis of ASD remains unknown. Although studies report dopamine signaling abnormalities in autistic patients, a coherent dopamine h...

journal_title：Developmental neuroscience

authors： Pavăl D

更新日期：2017-01-01 00:00:00

abstract：:The M50 and M100 auditory evoked responses reflect early auditory processes in the primary/secondary auditory cortex. Although previous M50 and M100 studies have been conducted on individuals with autism spectrum disorder (ASD) and indicate disruption of encoding simple sensory information, analogous investigations of...

journal_title：Developmental neuroscience

authors： Matsuzaki J,Ku M,Dipiero M,Chiang T,Saby J,Blaskey L,Kuschner ES,Kim M,Berman JI,Bloy L,Chen YH,Dell J,Liu S,Brodkin ES,Embick D,Roberts TPL

更新日期：2019-01-01 00:00:00

abstract：:Neonatal stroke leads to mortality and severe morbidity, but there is no effective treatment currently available. Erythropoietin (EPO) has been shown to promote cytoprotection and neurogenesis and decrease subventricular zone morphologic changes following brain injury. The long-term cellular response to EPO has not be...

journal_title：Developmental neuroscience

authors： Gonzalez FF,McQuillen P,Mu D,Chang Y,Wendland M,Vexler Z,Ferriero DM

更新日期：2007-01-01 00:00:00

abstract：:Ethanol inhibition of L1-mediated cell adhesion may contribute to the spectrum of neurological, behavioral and morphological abnormalities associated with prenatal ethanol exposure. We showed previously that the neuroprotective peptides NAPVSIPQ (NAP) and SALLRSIPA (SAL) antagonize ethanol inhibition of L1 adhesion an...

journal_title：Developmental neuroscience

authors： Chen SY,Charness ME,Wilkemeyer MF,Sulik KK

更新日期：2005-01-01 00:00:00

abstract：:The neurochemical effect of postnatal exposure to methadone (METH), undernutrition (UND), and methadone and undernutrition (METH-UND) on the whole brain and cerebellum were examined in 21- and 60-day-old rats. At 21 days, body weight reductions of UND and METH-UND rats exceeded that of the METH animals. However, METH ...

journal_title：Developmental neuroscience

authors： Zagon IS,McLaughlin PJ

更新日期：1982-01-01 00:00:00

abstract：:Stromal-derived factor 1 (SDF-1), a known chemoattractant, and its receptor CXCR4 are widely expressed in the developing and adult cerebral cortex. Recent studies have highlighted potential roles for SDF-1 during early cortical development. In view of the current findings, our histological analysis has revealed a dist...

journal_title：Developmental neuroscience

authors： Liapi A,Pritchett J,Jones O,Fujii N,Parnavelas JG,Nadarajah B

更新日期：2008-01-01 00:00:00

abstract：:Adrenoleukodystrophy (ALD) is an X-linked recessive disorder that affects mainly the nervous system white matter and the adrenal cortex. It is associated with an abnormal accumulation of saturated very long chain fatty acids and can be diagnosed by demonstrating an excess of these substances in plasma or red cells. Ou...

journal_title：Developmental neuroscience

authors： Moser HW,Moser AB,Naidu S,Bergin A

更新日期：1991-01-01 00:00:00

abstract：:The distribution of the noradrenergic system within the rat cerebellar cortex following low-level X-irradiation was studied using tyrosine hydroxylase immunocytochemistry. X-Irradiation treatments consisted of 1, 3, or 5 successive daily dose beginning on postnatal day 1. When studied 24 h after the last exposure, a d...

journal_title：Developmental neuroscience

authors： Kunkler PE,Anderson WJ

更新日期：1994-01-01 00:00:00

abstract：:Pediatric traumatic brain injury is a significant problem that affects many children each year. Progress is being made in developing neuroprotective strategies to combat these injuries. However, investigators are a long way from therapies to fully preserve injured neurons and glia. To restore neurological function, re...

journal_title：Developmental neuroscience

authors： Goodus MT,Guzman AM,Calderon F,Jiang Y,Levison SW

更新日期：2015-01-01 00:00:00

abstract：:L-Ornithine decarboxylase (ODC), the rate-limiting enzyme of polyamine biosynthesis and thus a unique marker of the proliferation and maturation processes, has been localized by means of immunohistochemistry in the human central nervous system. The enzyme protein has not only been found in the developing nervous syste...

journal_title：Developmental neuroscience

authors： Müller M,Pajunen AE,Järvinen M,Poeggel G,Bernstein HG

更新日期：1993-01-01 00:00:00

abstract：:All known actions of cAMP in the brain require cAMP-dependent protein kinase (cAMPdPK), which consists of regulatory (R) and catalytic (C) subunits (R2C2). Using homologous rat cDNAs for all known cAMPdPK subunit isoforms found in the brain (RI alpha, RI beta, RII alpha, RII beta, C alpha, C beta) we observe that, in ...

journal_title：Developmental neuroscience

authors： Massa JS,Walker PS,Moser DR,Fellows RE,Maurer RA

更新日期：1991-01-01 00:00:00

abstract：:We have previously provided evidence that ferritin binds selectively to white matter tracts in adult mouse and human brains. In cell culture experiments, ferritin binding is specifically localized to oligodendrocytes. The goal of the present study is to test the hypothesis that the developmental pattern for ferritin b...

journal_title：Developmental neuroscience

authors： Hulet SW,Menzies S,Connor JR

更新日期：2002-01-01 00:00:00

abstract：:Creatine kinase (CK) isoenzymes, with emphasis on the mitochondrial CK isoenzymes, were characterized and localized in chicken cerebellum. Chicken cerebellum extracts analyzed by two-dimensional gels, using antipeptide antibodies specific for sarcomeric muscle-type mitochondrial CK (Mib-CK) and revealed the presence o...

journal_title：Developmental neuroscience

authors： Kaldis P,Hemmer W,Zanolla E,Holtzman D,Wallimann T

更新日期：1996-01-01 00:00:00