Is being plastic fantastic? Mechanisms of altered plasticity after developmental traumatic brain injury.

abstract：:This study investigated the time of expression of two endothelial cell adhesion molecules, ICAM-1/CD54 and PECAM-1/CD31 in the developing postpartum mouse blood-brain barrier (BBB). Immunoultrastructural studies demonstrated that both adhesion molecules are initially expressed primarily on the luminal endothelial cell...

journal_title：Developmental neuroscience

authors： Lossinsky AS,Wisniewski HM

更新日期：1998-01-01 00:00:00

abstract：:We have previously provided evidence that ferritin binds selectively to white matter tracts in adult mouse and human brains. In cell culture experiments, ferritin binding is specifically localized to oligodendrocytes. The goal of the present study is to test the hypothesis that the developmental pattern for ferritin b...

journal_title：Developmental neuroscience

authors： Hulet SW,Menzies S,Connor JR

更新日期：2002-01-01 00:00:00

abstract：:Neural stem cells are attracting enormous attention in regenerative medicine due to their ability to self-renew and differentiate into the cell lineages that constitute the central nervous system. However, little is known about the mechanism underlying the regulation of their redox environment, which is essential for ...

journal_title：Developmental neuroscience

authors： Sharma N,Moore L,Chidambaram S,Colangelo NW,de Toledo SM,Azzam EI

更新日期：2018-01-01 00:00:00

abstract：:Neuronal heterotopia is a malformation of cortical development that is closely associated with epilepsy in humans. Despite emerging interest in the structure and function of the heterotopic cortex, little is known about the membrane properties and synaptic connections of these displaced neurons. We used whole-cell pat...

journal_title：Developmental neuroscience

authors： Smith BN,Dudek FE,Roper SN

更新日期：1999-11-01 00:00:00

abstract：:In the presence of nerve growth factor (NGF) PC12 pheochromocytoma cells develop properties of sympathetic neurons and extend long microtubule-containing neurites. PC12 cell microtubule protein was isolated using an assembly and disassembly procedure, either directly from an unlabeled cell extract or by copolymerizati...

journal_title：Developmental neuroscience

authors： Richter-Landsberg C,Landreth GE,Shooter EM

更新日期：1983-01-01 00:00:00

abstract：:We investigated the effects of perinatal hypoxia-ischemia (HI) on brain injury and neurological functional outcome at postnatal day (P)30 through P90. HI was induced by exposing P9 mice to 8% O(2) for 55 min using the Vannucci HI model. Following HI, mice were treated with either vehicle control or Na(+)/H(+) exchange...

journal_title：Developmental neuroscience

authors： Cengiz P,Uluc K,Kendigelen P,Akture E,Hutchinson E,Song C,Zhang L,Lee J,Budoff GE,Meyerand E,Sun D,Ferrazzano P

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Neonatal hypoxic-ischemic (HI) encephalopathy occurs in 1-4 per 1,000 live term births and can cause devastating neurodevelopmental disabilities. Currently, therapeutic hypothermia (TH) is the only treatment with proven efficacy. Since TH is associated with decreased cerebral metabolism and cerebral blood fl...

journal_title：Developmental neuroscience

authors： Buckley EM,Patel SD,Miller BF,Franceschini MA,Vannucci SJ

更新日期：2015-01-01 00:00:00

abstract：:Nitric oxide (NO) is a recently recognized messenger molecule that has been shown to possess pleiotropic properties, including vasodilation, neurotransmission, cytotoxicity and antimicrobial activity. Constitutive and inducible forms of NO synthase (NOS) have been identified. Activation of cNOS releases relatively low...

journal_title：Developmental neuroscience

authors： Brosnan CF,Battistini L,Raine CS,Dickson DW,Casadevall A,Lee SC

更新日期：1994-01-01 00:00:00

abstract：:Dissociated brain cell cultures are a useful model for investigating development and differentiation of oligodendrocytes in vitro. The current studies compare the developmental patterns of expression for oligodendrocyte lineage/myelin markers in both primary and secondary oligodendrocyte cultures derived from mouse an...

journal_title：Developmental neuroscience

authors： Duchala CS,Asotra K,Macklin WB

更新日期：1995-01-01 00:00:00

abstract：:Neurotoxicological studies have indicated that L-glutamate exhibits more pronounced effects on the preoptic area (POA) neurons of male rats than on those of females in the neonatal period. However, no information has previously been available as to whether or not such sexual dimorphism also exists for the effects of g...

journal_title：Developmental neuroscience

authors： Hsu C,Hsieh YL,Ho ML,Hsu HK,Yu JY

更新日期：2001-01-01 00:00:00

abstract：:The metabolism of [1-13C]D-glucose by astrocytes, neurons and mixed astroglial/neuronal cultures derived from the striatum of fetal rats was studied using NMR. Metabolic activity was studied in resting and depolarized cells (55 mM K+), with dibutyryl cyclic-AMP added to the medium to promote cell differentiation, and ...

journal_title：Developmental neuroscience

authors： Leo GC,Driscoll BF,Shank RP,Kaufman E

更新日期：1993-01-01 00:00:00

abstract：:The cell line MN9D, a fusion of embryonic ventral mesencephalic and neuroblastoma cells, is extensively used as a model of dopamine (DA) neurons because it expresses tyrosine hydroxylase and synthesizes and releases DA. These cells are also used to test mechanisms and potential therapeutics relevant to the loss of DA ...

journal_title：Developmental neuroscience

authors： Rick CE,Ebert A,Virag T,Bohn MC,Surmeier DJ

更新日期：2006-01-01 00:00:00

abstract：:Fragments of corpus callosum from P13 normal and jimpy (jp) mutant mice (containing only postmigrating precursors and differentiated oligodendrocytes (ODCs, some of them myelinating soon) have been transplanted into the thalamus of newborn shiverer (shi) mutant mice. The behaviour of transplanted ODCs has been assayed...

journal_title：Developmental neuroscience

authors： Lachapelle F,Lapie P,Gumpel M

更新日期：1992-01-01 00:00:00

abstract：:In the socially monogamous prairie vole, we have observed that small changes in early handling, as well as early hormonal manipulations can have long-lasting and sexually dimorphic effects on behavior. These changes may be mediated in part by changes in parental interactions with their young, acting on systems that re...

journal_title：Developmental neuroscience

authors： Carter CS,Boone EM,Pournajafi-Nazarloo H,Bales KL

更新日期：2009-01-01 00:00:00

abstract：:Neonatal stroke leads to mortality and severe morbidity, but there is no effective treatment currently available. Erythropoietin (EPO) has been shown to promote cytoprotection and neurogenesis and decrease subventricular zone morphologic changes following brain injury. The long-term cellular response to EPO has not be...

journal_title：Developmental neuroscience

authors： Gonzalez FF,McQuillen P,Mu D,Chang Y,Wendland M,Vexler Z,Ferriero DM

更新日期：2007-01-01 00:00:00

abstract：:The expression of voltage-gated potassium channels plays an important role in the acquisition of membrane excitability in neurons. We examined the expression pattern of genes in developing cerebellar granule neurons in vivo and in vitro. In situ hybridization of Kv3.1 mRNA demonstrated that the gene was expressed at h...

journal_title：Developmental neuroscience

authors： Shibata R,Wakazono Y,Nakahira K,Trimmer JS,Ikenaka K

更新日期：1999-01-01 00:00:00

abstract：:Various abnormalities in frontal and striatal regions have been reported in children with prenatal alcohol and/or methamphetamine exposure. In a recent fMRI study, we observed a correlation between accuracy on a working-memory task and functional activation in the putamen in children with prenatal methamphetamine and ...

journal_title：Developmental neuroscience

authors： Roussotte FF,Rudie JD,Smith L,O'Connor MJ,Bookheimer SY,Narr KL,Sowell ER

更新日期：2012-01-01 00:00:00

abstract：:Choline acetyltransferase (ChAT), the biosynthetic enzyme for acetylcholine metabolism, is expressed in a human cholinergic neuroblastoma cell line; MC-IXC. We demonstrate that ChAT activity is regulated in this cell line by cell density. It is believed that the mechanism of stimulation of enzyme activity involves cel...

journal_title：Developmental neuroscience

authors： Casper D,Davies P

更新日期：1988-01-01 00:00:00

abstract：:The developing retina is characterized by 'retinal waves', spontaneous depolarizations that propagate through a developing network of interneurons and retinal ganglion cells. Although the circuitry underlying retinal waves is well characterized, the secreted factors that are critical for its normal development are not...

journal_title：Developmental neuroscience

authors： Colicos MA,Firth SI,Bosze J,Goldstein J,Feller MB

更新日期：2004-01-01 00:00:00

abstract：:Dissociated cells of cerebral hemispheres from 8-day-old chick embryos were cultivated for 8 days in polylysine-coated Petri dishes. Changes of DNA, RNA, total proteins, putrescine, spermidine, spermine, free amino acids and enzymes involved in polyamine and GABA metabolism were studied throughout neuronal development...

journal_title：Developmental neuroscience

authors： Seiler N,Sarhan S,Roth-Schechter BF

更新日期：1981-01-01 00:00:00

abstract：:Maternal peptides from the hypothalamic-pituitary-adrenal (HPA) axis rise during human pregnancy. The effects of circulating maternal adrenocorticotropin (ACTH) and beta-endorphin (BE) on human fetal behavior was determined in 135 women during their 32nd week of gestation. Fetal behavior was measured by assessing hear...

journal_title：Developmental neuroscience

authors： Sandman CA,Glynn L,Wadhwa PD,Chicz-DeMet A,Porto M,Garite T

更新日期：2003-01-01 00:00:00

abstract：:The norepinephrine content of hypothalamus in vehicle-treated control rats gradually increases between days 16 and 45 of life. Norepinephrine contents of the hypothalamus and mesencephalon of the thyroxine-treated (10 microgram/g b.w., s.c., days 8-10) animals also increase between days 16 and 21. Mesencephalic and hy...

journal_title：Developmental neuroscience

authors： Lengvári I,Branch BJ,Taylor AN

更新日期：1980-01-01 00:00:00

abstract：:Radiotherapy is an effective treatment strategy in the treatment of brain tumors, but it is also a major cause of long-term complications, especially in survivors of pediatric brain tumors. Cognitive decline caused by cranial radiotherapy is thought, at least partly, to depend on injury to stem and progenitor cells in...

journal_title：Developmental neuroscience

authors： Roughton K,Andreasson U,Blomgren K,Kalm M

更新日期：2013-01-01 00:00:00

abstract：:Cortical dysplasia (CD) is now recognized as one of the major causes of pediatric focal neocortical epilepsy, and surgical procedures have been considered early in life. However, the mechanisms involved in seizure generation and intractability in these patients are still unknown. We analyzed with immunocytochemistry f...

journal_title：Developmental neuroscience

authors： Hilbig A,Babb TL,Najm I,Ying Z,Wyllie E,Bingaman W

更新日期：1999-11-01 00:00:00

abstract：:The fine structure of pituicytes was investigated between 15 days of fetal life and 120 days postnatum. Prior to the penetration of neurosecretory axons into the neural lobe a uniform population of undifferentiated pituicytes is presented. Coincidental with the first appearance of neurosecretory axons in the neural lo...

journal_title：Developmental neuroscience

authors： Dellmann HD,Sikora K

更新日期：1981-01-01 00:00:00

abstract：:Proper eye formation depends on specific interactions between neural and ectodermal tissues coupled with temporally distinct gene expression and a regulated sequence of signaling events. The homeobox gene Pax6 is vitally important to the entire process of eye development in both vertebrates and invertebrates. Pax6 exp...

journal_title：Developmental neuroscience

authors： Reza HM,Yasuda K

更新日期：2004-01-01 00:00:00

abstract：:Rats were exposed to mild hyperoxia and hypoxia by the administration of oxygen/air and nitrogen/air mixtures through plastic tubing held close to their snouts for periods of 3 min. Changes in tissue oxygen were monitored at an implanted carbon paste electrode; local cerebral blood flow (rCBF) at an implanted platinum...

journal_title：Developmental neuroscience

authors： Lowry JP,Demestre M,Fillenz M

更新日期：1998-01-01 00:00:00

abstract：:Adult GM2 gangliosidosis is a rare autosomal recessive disease with widely varying neurological and psychiatric manifestations. It is caused by marked deficiency, but not total absence, of beta-hexosaminidase (Hex) A, due to a single base change in the alpha-subunit gene of Hex, resulting in a substitution of Ser for ...

journal_title：Developmental neuroscience

authors： Navon R

更新日期：1991-01-01 00:00:00

abstract：:The cerebromicrovasculature of immature mice ranging in age from 1-24 days after birth was studied by electron microscopy. A micromanipulator apparatus enabled us to facilitate direction of a needle cannula and injection into leg veins or hearts with horseradish peroxidase (HRP) or ferritin (anionic and cationic) trac...

journal_title：Developmental neuroscience

authors： Lossinsky AS,Vorbrodt AW,Wisniewski HM

更新日期：1986-01-01 00:00:00

abstract：:Prenatal cocaine exposure results in behavioral abnormalities throughout development in rats, but little is known regarding the biological mechanisms underlying these abnormalities. Pregnant rats received subcutaneous twice-daily injections (1 ml/kg) of normal saline or 15 mg/kg of cocaine hydrochloride throughout ges...

journal_title：Developmental neuroscience

authors： Johns JM,Lubin DA,Lieberman JA,Lauder JM

更新日期：2002-01-01 00:00:00