Abstract:
:Dissociated cells of cerebral hemispheres from 8-day-old chick embryos were cultivated for 8 days in polylysine-coated Petri dishes. Changes of DNA, RNA, total proteins, putrescine, spermidine, spermine, free amino acids and enzymes involved in polyamine and GABA metabolism were studied throughout neuronal development in culture. The presence of GABAergic neurons in the cultured cell population was demonstrated. There were time-dependent changes in cellular polyamine concentrations and the activities of the enzymes involved in polyamine metabolism. Since no significant proliferation took place after the first day in culture, the observed changes indicate a role of polyamine metabolism during neuronal differentiation; it was not possible, however, to attribute the observed changes to specific functions. This culture system seems especially useful for the study of biochemical and of functional correlations between GABA and polyamine metabolism and morphological and functional developments of neurons.
journal_name
Dev Neuroscijournal_title
Developmental neuroscienceauthors
Seiler N,Sarhan S,Roth-Schechter BFdoi
10.1159/000112755subject
Has Abstractpub_date
1981-01-01 00:00:00pages
181-7issue
3eissn
0378-5866issn
1421-9859journal_volume
4pub_type
杂志文章abstract::Neural stem cells are attracting enormous attention in regenerative medicine due to their ability to self-renew and differentiate into the cell lineages that constitute the central nervous system. However, little is known about the mechanism underlying the regulation of their redox environment, which is essential for ...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000493009
更新日期:2018-01-01 00:00:00
abstract::The hippocampal formation is a multicomponent region of the medial temporal lobe preferentially involved in declarative and relational memory processing. Behavioral studies have suggested a protracted functional maturation of these structures in primates, and postnatal developmental abnormalities in the hippocampal fo...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000096222
更新日期:2007-01-01 00:00:00
abstract::The distribution of the noradrenergic system within the rat cerebellar cortex following low-level X-irradiation was studied using tyrosine hydroxylase immunocytochemistry. X-Irradiation treatments consisted of 1, 3, or 5 successive daily dose beginning on postnatal day 1. When studied 24 h after the last exposure, a d...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112092
更新日期:1994-01-01 00:00:00
abstract::The lipids of white matter and peripheral nerve from mutant mice with known myelin deficiencies were analyzed by one- and two-dimensional high-performance thin-layer chromatography and quantitated by densitometry. In optic nerve, the mutants jp/Y, jpmsd/Y, qk/qk, shi/shi and shimld/shimld, which have severe central ne...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111961
更新日期:1988-01-01 00:00:00
abstract::The neurotoxic effect of monosodium L-glutamate (MSG) on the morphologies in the darkly stained sexually dimorphic nucleus of the preoptic area (SDN-POA) and the lighter-staining surrounding area (non-SDN-POA) within the medial preoptic nucleus (MPN) was evaluated. Male and female Long-Evans rats were used. MSG (4 mg/...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111231
更新日期:1997-01-01 00:00:00
abstract::The M50 and M100 auditory evoked responses reflect early auditory processes in the primary/secondary auditory cortex. Although previous M50 and M100 studies have been conducted on individuals with autism spectrum disorder (ASD) and indicate disruption of encoding simple sensory information, analogous investigations of...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000504960
更新日期:2019-01-01 00:00:00
abstract::There is an important unmet need to further improve the outcome of neonatal encephalopathy in term infants. Meta-analyses of large controlled trials now suggest that maternal magnesium sulfate (MgSO4) therapy is associated with a reduced risk of cerebral palsy and gross motor dysfunction after premature birth, but tha...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000362206
更新日期:2014-01-01 00:00:00
abstract::Proper eye formation depends on specific interactions between neural and ectodermal tissues coupled with temporally distinct gene expression and a regulated sequence of signaling events. The homeobox gene Pax6 is vitally important to the entire process of eye development in both vertebrates and invertebrates. Pax6 exp...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000082273
更新日期:2004-01-01 00:00:00
abstract::Early developmental treatment of rats with 3,4-methylenedioxymethamphetamine (MDMA) was previously found to cause an abnormal pattern of forebrain serotonergic axon density in adulthood consisting of a cortical hypoinnervation and a striatal hyperinnervation. The present study tested the hypothesis that this reorganiz...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000207497
更新日期:2009-01-01 00:00:00
abstract::A total of 216 male and female albino Wistar rats (Rattus norvegicus) between 10 and 60 days old from 42 litters were studied to determine mast cell characteristics within the thalamus. Whereas the mean numbers of mast cells within both the parenchyma and leptomeninges (combined) did not change appreciably after 15 da...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112759
更新日期:1981-01-01 00:00:00
abstract::Prenatal cocaine exposure results in behavioral abnormalities throughout development in rats, but little is known regarding the biological mechanisms underlying these abnormalities. Pregnant rats received subcutaneous twice-daily injections (1 ml/kg) of normal saline or 15 mg/kg of cocaine hydrochloride throughout ges...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000069363
更新日期:2002-01-01 00:00:00
abstract::We studied the developmental changes of soluble and membrane-bound protein kinases (EC 2.7.1.37) in rat brain and found that the elution profiles from a DEAE-cellulose column by NaCl of adenosine-3':5'-monophosphate (cyclic AMP) dependent protein kinase from cytosol were not significantly different in newborn (0.19 M ...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112450
更新日期:1979-01-01 00:00:00
abstract::Adult neuronal ceroid lipofuscinosis (NCL), also called Kufs' disease, is clinically distinct from the other NCLs. It is a rare condition which is difficult to diagnose. More than 50% of the reported cases of Kufs' disease are not adult NCL and correspond very likely to a heterogeneous spectrum of lipidoses. Various c...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000112182
更新日期:1991-01-01 00:00:00
abstract::In the developing brain the majority of neurons migrate from their birthplace to their final destination. This active movement is essential for the formation of cortical layers and nuclei. The impairment of migration does not affect the viability of neurons but often results in abnormal differentiation. The proper mig...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000109847
更新日期:2008-01-01 00:00:00
abstract::Hypoxic-ischemic brain injury is a leading cause of neurodevelopmental morbidities in preterm and full-term infants. Blood-brain barrier dysfunction represents an important component of perinatal hypoxic-ischemic brain injury. The extracellular matrix (ECM) is a vital component of the blood-brain barrier. Matrix metal...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000489700
更新日期:2018-01-01 00:00:00
abstract::Reactive oxygen species (ROS) have been reported to affect neural stem cell self-renewal and therefore may be important for normal development and may influence neurodegenerative processes when ROS activity is elevated. To determine if increasing production of superoxide, via activation of NADPH oxidase (Nox), increas...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000350502
更新日期:2013-01-01 00:00:00
abstract::The developing retina is characterized by 'retinal waves', spontaneous depolarizations that propagate through a developing network of interneurons and retinal ganglion cells. Although the circuitry underlying retinal waves is well characterized, the secreted factors that are critical for its normal development are not...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000082283
更新日期:2004-01-01 00:00:00
abstract::We report on the effects of etiology and age on the linguistic outcomes in a large pediatric hemispherectomy population. Four populations were considered separately: cortical dysplasia (multilobar involvement), Rasmussen's encephalitis, infarction as a primary etiology and, fourth, children who failed to develop langu...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000017396
更新日期:1999-11-01 00:00:00
abstract::Disorders primarily affecting the nervous system comprise approximately one third of all established Mendelian genetic diseases in man. Recombinant DNA technology provides new approaches to the diagnosis and elucidation of the molecular pathology of these disorders. For a small but increasing number of disorders the D...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000112346
更新日期:1983-01-01 00:00:00
abstract::Quaking is a neurological mutation leading to pleiotropic phenotypic expression, the most prominent being disturbed myelin formation in the central nervous system (CNS) with minor abnormalities in the peripheral nervous system. Previous immunochemical measurements of glial fibrillary acidic protein (GFAP) revealed a m...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111682
更新日期:1992-01-01 00:00:00
abstract::There is pressing need to employ new advances in structural MR brain imaging to better diagnose brain damage in newborn infants. Timely application of such technology will enable improved therapeutic interventions. Diffusion-weighted sequences are a sensitive marker of very early neuronal injury, the spatial pattern o...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000085988
更新日期:2005-03-01 00:00:00
abstract::Creatine kinase (CK) isoenzymes, with emphasis on the mitochondrial CK isoenzymes, were characterized and localized in chicken cerebellum. Chicken cerebellum extracts analyzed by two-dimensional gels, using antipeptide antibodies specific for sarcomeric muscle-type mitochondrial CK (Mib-CK) and revealed the presence o...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000111452
更新日期:1996-01-01 00:00:00
abstract::The distal segments of the crush-injured and permanently transected sciatic nerve provide models to study Schwann cell activity in the presence and absence of Schwann cell-axonal contact, respectively. We examined the quantity and quality of transcript coding for the myelin-associated glycoprotein (MAG) over a 3-week ...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111832
更新日期:1990-01-01 00:00:00
abstract::The proximodistal axonal transport of choline acetyltransferase (ChAc) has been studied in the chick sciatic nerve in the absence of any experimental manipulation. The phenomenon utilized by us is a physiological transient fall in the activity of ChAc. This fall occurs in most areas of the chick central nervous system...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112484
更新日期:1979-01-01 00:00:00
abstract::HIV-1 is able to penetrate the developing human central nervous system and induce damage. Clinical and neuropathological observations demonstrate that (a) the virus is transmitted during the late phase of pregnancy or at the time of delivery; (b) the main infected cells within the brain are macrophages, and (c) the me...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000112100
更新日期:1994-01-01 00:00:00
abstract::Our previous studies of H218, a sphingosine 1-phosphate (S1P) receptor and a member of the G-protein-coupled receptor superfamily, suggest that it may participate in mammalian nervous system development. Thus, brain levels of H218 mRNA are higher during early neurogenesis than postnatally. In addition, embryonic H218 ...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000017452
更新日期:2000-01-01 00:00:00
abstract::The postnatal developmental expression and the distribution of the glutamate transporters (GLAST, GLT-1 and EAAC1) were analyzed in rat vestibular nuclei (VN), at birth and during the following 4 weeks. Analyses were performed using reverse transcriptase-polymerase chain reaction and immunoblotting of GLAST, GLT-1 and...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000073510
更新日期:2003-09-01 00:00:00
abstract::Transient early cerebral laminar organization resulting from normal developmental events has been revealed in human beings through histology and imaging studies. DTI studies have postulated that the fractional anisotropy (FA)-based differentiation of different laminar structures reflects both differing cellular densit...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000229500
更新日期:2009-01-01 00:00:00
abstract::Nitric oxide may serve as a retrograde messenger to refine or stabilize synapses in the developing nervous system. Whether this action is dependent upon glutamate and the N-methyl-D-aspartate receptor is not yet established. We have used the patch-cluster system in the intermediate gray layer (IGL) of the rat superior...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111215
更新日期:1997-01-01 00:00:00
abstract::Neurotoxicological studies have indicated that L-glutamate exhibits more pronounced effects on the preoptic area (POA) neurons of male rats than on those of females in the neonatal period. However, no information has previously been available as to whether or not such sexual dimorphism also exists for the effects of g...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000048726
更新日期:2001-01-01 00:00:00