Characterization of endothelial cell transport in the developing mouse blood-brain barrier.

abstract：:Developmental changes in gangliosides in the course of neurite outgrowth were examined in dissociated fetal rat cerebral neurons in culture. About a 2-fold increase in ganglioside levels was seen with the progression of neurite formation for up to 24 h in predominantly neuronal cultures. Ganglioside patterns appeared ...

journal_title：Developmental neuroscience

authors： Ogiso M,Ohta M,Harada Y,Hirano S

更新日期：1992-01-01 00:00:00

abstract：:In vertebrate species, the neuropeptide oxytocin (OT) has been implicated in neural and behavioral development. Although several OT-like peptides have been characterized in invertebrate species, the ontogenesis of the OT-like system has not yet been described in these species. Thus, the aim of the present study was to...

journal_title：Developmental neuroscience

authors： Bardou I,Maubert E,Leprince J,Chichery R,Dallérac G,Vaudry H,Agin V

更新日期：2010-03-01 00:00:00

abstract：:The neurotoxic effect of monosodium L-glutamate (MSG) on the morphologies in the darkly stained sexually dimorphic nucleus of the preoptic area (SDN-POA) and the lighter-staining surrounding area (non-SDN-POA) within the medial preoptic nucleus (MPN) was evaluated. Male and female Long-Evans rats were used. MSG (4 mg/...

journal_title：Developmental neuroscience

authors： Hsieh YL,Hsu C,Lue SI,Hsu HK,Peng MT

更新日期：1997-01-01 00:00:00

abstract：:Astrocytes in primary cultures constitute an exceedingly useful preparation for studies of astroglial development and function. These cells, however, demonstrate a pronounced plasticity in their reactions to culturing conditions. Thus, species and spatiotemporal region of CNS chosen for source of cells, dissociation p...

journal_title：Developmental neuroscience

authors： Juurlink BH,Hertz L

更新日期：1985-01-01 00:00:00

abstract：:Cortical dysplasia (CD) is now recognized as one of the major causes of pediatric focal neocortical epilepsy, and surgical procedures have been considered early in life. However, the mechanisms involved in seizure generation and intractability in these patients are still unknown. We analyzed with immunocytochemistry f...

journal_title：Developmental neuroscience

authors： Hilbig A,Babb TL,Najm I,Ying Z,Wyllie E,Bingaman W

更新日期：1999-11-01 00:00:00

abstract：:We have previously provided evidence that ferritin binds selectively to white matter tracts in adult mouse and human brains. In cell culture experiments, ferritin binding is specifically localized to oligodendrocytes. The goal of the present study is to test the hypothesis that the developmental pattern for ferritin b...

journal_title：Developmental neuroscience

authors： Hulet SW,Menzies S,Connor JR

更新日期：2002-01-01 00:00:00

abstract：:The postnatal developmental expression and the distribution of the glutamate transporters (GLAST, GLT-1 and EAAC1) were analyzed in rat vestibular nuclei (VN), at birth and during the following 4 weeks. Analyses were performed using reverse transcriptase-polymerase chain reaction and immunoblotting of GLAST, GLT-1 and...

journal_title：Developmental neuroscience

authors： Devau G,Plachez C,Puyal J,Pierrot N,Ventéo S,Raymond J

更新日期：2003-09-01 00:00:00

abstract：:Radiotherapy is an effective treatment strategy in the treatment of brain tumors, but it is also a major cause of long-term complications, especially in survivors of pediatric brain tumors. Cognitive decline caused by cranial radiotherapy is thought, at least partly, to depend on injury to stem and progenitor cells in...

journal_title：Developmental neuroscience

authors： Roughton K,Andreasson U,Blomgren K,Kalm M

更新日期：2013-01-01 00:00:00

abstract：:Adult GM2 gangliosidosis is a rare autosomal recessive disease with widely varying neurological and psychiatric manifestations. It is caused by marked deficiency, but not total absence, of beta-hexosaminidase (Hex) A, due to a single base change in the alpha-subunit gene of Hex, resulting in a substitution of Ser for ...

journal_title：Developmental neuroscience

authors： Navon R

更新日期：1991-01-01 00:00:00

abstract：:NeuroD is a basic helix-loop-helix (bHLH) transcription factor cloned from a two hybrid screen designed to search for new bHLH proteins. In our previous studies, we showed that NeuroD could convert Xenopus ectoderm into fully differentiated neurons and that it could prematurely differentiate neural precursor cells in ...

journal_title：Developmental neuroscience

authors： Lee JE

更新日期：1997-01-01 00:00:00

abstract：:The fine structure of pituicytes was investigated between 15 days of fetal life and 120 days postnatum. Prior to the penetration of neurosecretory axons into the neural lobe a uniform population of undifferentiated pituicytes is presented. Coincidental with the first appearance of neurosecretory axons in the neural lo...

journal_title：Developmental neuroscience

authors： Dellmann HD,Sikora K

更新日期：1981-01-01 00:00:00

abstract：:Neurotoxicological studies have indicated that L-glutamate exhibits more pronounced effects on the preoptic area (POA) neurons of male rats than on those of females in the neonatal period. However, no information has previously been available as to whether or not such sexual dimorphism also exists for the effects of g...

journal_title：Developmental neuroscience

authors： Hsu C,Hsieh YL,Ho ML,Hsu HK,Yu JY

更新日期：2001-01-01 00:00:00

abstract：:There is pressing need to employ new advances in structural MR brain imaging to better diagnose brain damage in newborn infants. Timely application of such technology will enable improved therapeutic interventions. Diffusion-weighted sequences are a sensitive marker of very early neuronal injury, the spatial pattern o...

journal_title：Developmental neuroscience

authors： Sfaello I,Daire JL,Husson I,Kosofsky B,Sebag G,Gressens P

更新日期：2005-03-01 00:00:00

abstract：:Reactive oxygen species (ROS) have been reported to affect neural stem cell self-renewal and therefore may be important for normal development and may influence neurodegenerative processes when ROS activity is elevated. To determine if increasing production of superoxide, via activation of NADPH oxidase (Nox), increas...

journal_title：Developmental neuroscience

authors： Topchiy E,Panzhinskiy E,Griffin WS,Barger SW,Das M,Zawada WM

更新日期：2013-01-01 00:00:00

abstract：:Metabolism of glutamate and glutamine in cultured mouse cerebral cortical astrocytes has been investigated using either radioactively labelled (14C) amino acids or 13C-labelled amino acids combined with NMR spectroscopy of cell extracts and lyophilyzed incubation media. Using [U-13C]glutamate it has been shown that in...

journal_title：Developmental neuroscience

authors： Schousboe A,Westergaard N,Sonnewald U,Petersen SB,Huang R,Peng L,Hertz L

更新日期：1993-01-01 00:00:00

abstract：:The current work tested the hypothesis that the zinc status of a cell influences its sensitivity to iron-induced oxidative stress. Human IMR-32 neuroblastoma cells were cultured for 24 h in nonchelated control media (5 microM zinc; 4.5 microM iron), or in media that was treated with DTPA to reduce its zinc content (ch...

journal_title：Developmental neuroscience

authors： Mackenzie GG,Keen CL,Oteiza PI

更新日期：2002-01-01 00:00:00

abstract：:In order to investigate the possible influence of norepinephrine (NE) on neuronal development, the effects of neonatal NE depletion on postnatally developing cell populations were characterized in (1) the normal mouse cerebellum, and (2) a cerebellar model system with delayed germinal cell development produced by neon...

journal_title：Developmental neuroscience

authors： Lovell KL

更新日期：1982-01-01 00:00:00

abstract：:Several studies have shown that exogenous gangliosides can stimulate neurite outgrowth (in vitro), accelerate peripheral nerve regeneration (in vivo) and facilitate CNS recovery after lesioning. Experiments were designed to assess the effects of ganglioside administration on neonatal development. Rat neonates received...

journal_title：Developmental neuroscience

authors： Karpiak SE,Vilim F,Mahadik SP

更新日期：1983-01-01 00:00:00

abstract：:The activity of glycerophosphorylcholine phosphodiesterases was determined in the mesencephalon, diencephalon, cerebral hemispheres, cerebellum and olfactory bulb during postnatal development from P5 to P70 of rat brain. These activities are low and gradually increase to near adult levels by the end of the first postn...

journal_title：Developmental neuroscience

authors： Kanfer JN,McCartney DG

更新日期：1989-01-01 00:00:00

abstract：:Cerebral metabolism is known to be highly dependent upon glucose utilisation. In the neonate, severe hypoglycaemia is now recognized to be associated with subsequent adverse neurodevelopment and in extremis glial and neuronal cell death. However, the level at which hypoglycaemia becomes clinically important is not wel...

journal_title：Developmental neuroscience

authors： Land JM

更新日期：1994-01-01 00:00:00

abstract：:In some cells, the development of voltage-gated channels requires synaptic input, while in others it does not. Here we investigate whether the sodium and potassium currents in the skeletal muscle of zebrafish sofa potato (sop(-/-)) mutants develop normally. Zebrafish sop(-/-) mutants do not express nicotinic acetylcho...

journal_title：Developmental neuroscience

authors： Coutts CA,Cunningham ME,Ali DW

更新日期：2009-01-01 00:00:00

abstract：:Prenatal fever could result in brain function impairments in the offspring. The present study investigated the effect of interleukin-6 (IL-6)-induced maternal fever on the offspring and the involvement of connexin 36 in this process. Pregnant C57BL/6J mice were injected with IL-6 on gestational day 15. The levels of i...

journal_title：Developmental neuroscience

authors： Wang R,Yang Y,Xiao M,Guo B,Liu W,Wang H

更新日期：2019-01-01 00:00:00

abstract：:Myelinogenesis in different brain parts of trout was studied comparatively by means of histochemistry and biochemistry. A more detailed approach, including ultrastructural analysis, to characterize this important differentiation process, particularly in the optic tectum, revealed a good correlation between the structu...

journal_title：Developmental neuroscience

authors： Jeserich G

更新日期：1981-01-01 00:00:00

abstract：:The proximodistal axonal transport of choline acetyltransferase (ChAc) has been studied in the chick sciatic nerve in the absence of any experimental manipulation. The phenomenon utilized by us is a physiological transient fall in the activity of ChAc. This fall occurs in most areas of the chick central nervous system...

journal_title：Developmental neuroscience

authors： Giacobini G,Cannas M,Panattoni GL,Filogamo G

更新日期：1979-01-01 00:00:00

abstract：:Prenatal stress has been associated with detrimental outcomes of pregnancy, including altered brain development leading to behavioural pathologies. The neurosteroid allopregnanolone has been implicated in mediating some of these adverse outcomes following prenatal stress due to its potent inhibitory and anxiolytic eff...

journal_title：Developmental neuroscience

authors： Bennett GA,Palliser HK,Shaw JC,Walker D,Hirst JJ

更新日期：2015-01-01 00:00:00

abstract：:Fragments of corpus callosum from P13 normal and jimpy (jp) mutant mice (containing only postmigrating precursors and differentiated oligodendrocytes (ODCs, some of them myelinating soon) have been transplanted into the thalamus of newborn shiverer (shi) mutant mice. The behaviour of transplanted ODCs has been assayed...

journal_title：Developmental neuroscience

authors： Lachapelle F,Lapie P,Gumpel M

更新日期：1992-01-01 00:00:00

abstract：:Necrotizing enterocolitis (NEC) increases the risk of brain injury and impaired neurodevelopment. Rapid brain maturation prior to birth may explain why preterm brains are particularly vulnerable to serious infections. Using pigs as models, we hypothesized that preterm birth was associated with altered blood-cerebrospi...

journal_title：Developmental neuroscience

authors： Brunse A,Abbaspour A,Sangild PT

更新日期：2018-01-01 00:00:00

abstract：:Various abnormalities in frontal and striatal regions have been reported in children with prenatal alcohol and/or methamphetamine exposure. In a recent fMRI study, we observed a correlation between accuracy on a working-memory task and functional activation in the putamen in children with prenatal methamphetamine and ...

journal_title：Developmental neuroscience

authors： Roussotte FF,Rudie JD,Smith L,O'Connor MJ,Bookheimer SY,Narr KL,Sowell ER

更新日期：2012-01-01 00:00:00

abstract：:The myelin-associated glycoprotein (MAG) in primary cultures of oligodendrocytes is subject to phosphorylation in the absence of neurons. The positive response of this phosphorylation to vanadate suggests that one of the modified sites in MAG is phosphotyrosine. We found that phosphorylation was enhanced by brief trea...

journal_title：Developmental neuroscience

authors： Bambrick LL,Braun PE

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Therapeutic hypothermia provides incomplete neuroprotection for neonatal hypoxic-ischemic encephalopathy (HIE). We examined whether hemodynamic goals that support autoregulation are associated with decreased brain injury and whether these relationships are affected by birth asphyxia or vary by anatomic regio...

journal_title：Developmental neuroscience

authors： Lee JK,Poretti A,Perin J,Huisman TAGM,Parkinson C,Chavez-Valdez R,O'Connor M,Reyes M,Armstrong J,Jennings JM,Gilmore MM,Koehler RC,Northington FJ,Tekes A

更新日期：2017-01-01 00:00:00