Abstract:
:Although cortical malformations (CMs) are often associated with epilepsy, the underlying mechanisms are unknown. The reeler mouse is a model of CM with enhanced susceptibility to epileptiform activity, including the in vitro dentate gyrus, a region normally resistant to seizures. In this study, field potential recordings in hippocampal slices and the Timm stain were used to examine mossy fiber distribution in the dentate gyrus. In artificial cerebrospinal fluid containing bicuculline, 100% of reeler slices and 0% of control slices had spontaneous and antidromic evoked prolonged negative field potential shifts that were blocked by glutamate receptor antagonists. Sections from reeler mice, but not controls, exhibited a dark band of Timm's stain at the molecular layer/granule cell layer border. These data reveal that mossy fiber distribution is altered in reeler mice and coincides with the presence of an abnormal proconvulsive glutamatergic circuit.
journal_name
Dev Neuroscijournal_title
Developmental neuroscienceauthors
Patrylo PR,Willingham Adoi
10.1159/000096212subject
Has Abstractpub_date
2007-01-01 00:00:00pages
73-83issue
1-2eissn
0378-5866issn
1421-9859pii
96212journal_volume
29pub_type
杂志文章abstract::A total of 216 male and female albino Wistar rats (Rattus norvegicus) between 10 and 60 days old from 42 litters were studied to determine mast cell characteristics within the thalamus. Whereas the mean numbers of mast cells within both the parenchyma and leptomeninges (combined) did not change appreciably after 15 da...
journal_title:Developmental neuroscience
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pub_type: 杂志文章,评审
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journal_title:Developmental neuroscience
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journal_title:Developmental neuroscience
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journal_title:Developmental neuroscience
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doi:10.1159/000437302
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journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112695
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journal_title:Developmental neuroscience
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journal_title:Developmental neuroscience
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journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000086712
更新日期:2005-01-01 00:00:00
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journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000322887
更新日期:2011-01-01 00:00:00
abstract::Quaking is a neurological mutation leading to pleiotropic phenotypic expression, the most prominent being disturbed myelin formation in the central nervous system (CNS) with minor abnormalities in the peripheral nervous system. Previous immunochemical measurements of glial fibrillary acidic protein (GFAP) revealed a m...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111682
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journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
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更新日期:2006-01-01 00:00:00
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journal_title:Developmental neuroscience
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journal_title:Developmental neuroscience
pub_type: 杂志文章
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