Abstract:
:The L-type calcium channel activator +/-Bay K 8644 has recently been shown to provoke self-injurious biting in young mice. Since the serotonergic systems have been implicated in the expression of self-injurious behavior in both humans and animals, the present studies tested whether drugs influencing serotonin systems could modify the ability of +/-Bay K 8644 to cause this behavior. The ability of +/-Bay K 8644 to provoke self-biting behavior was increased by the serotonin uptake inhibitor fluoxetine or the monoamine oxidase inhibitor clorgyline. On the other hand, the ability of +/-Bay K 8644 to provoke self-biting was decreased by depletion of serotonin with p-chlorophenylalanine or 5,7-dihyroxytryptamine. These results suggest that the ability of +/-Bay K 8644 to provoke self-injurious behaviors may be mediated by serotonergic influences.
journal_name
Dev Neuroscijournal_title
Developmental neuroscienceauthors
Kasim S,Egami K,Jinnah HAdoi
10.1159/000066747keywords:
subject
Has Abstractpub_date
2002-01-01 00:00:00pages
322-7issue
4eissn
0378-5866issn
1421-9859pii
66747journal_volume
24pub_type
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