Abstract：
:We have previously reported that a developmental axon-sparing striatal injury induced by hypoxia-ischemia results in a diminished adult number of substantia nigra (SN) tyrosine hydroxylase (TH)-positive neurons, in the absence of direct nigral injury. To examine the specific role of striatal injury, we made selective striatal lesions in the 7-day-old rat with quinolinic acid (QA), 40, 80, 120 and 480 nmol. Striatal lesions resulted in a decrease in the adult number of TH-positive neurons in the ipsilateral SN. The decrease was correlated with the reduction in striatal area (r = 0.76, p < 0.01); a 25-30% reduction in SN neurons was observed at 50-60% striatal area loss. The area of SN pars compacta (SNpc) in animals with 120- and 480-nmol QA lesions was reduced by 12 and 15%, respectively (p < 0.01) and this reduction also correlated with the loss of striatal area (r = 0.63, p < 0.01). Individual TH-positive neuron size and neuron-packing density were unaltered in SNpc on the experimental side. We conclude that the adult number of SN dopaminergic neurons depends on developmental support by the striatum. We hypothesize that less support by the smaller striatum may result in accentuated developmental cell death in the SNpc.
journal_name
Dev Neuroscijournal_title
Developmental neuroscienceauthors
Macaya A,Burke REdoi
10.1159/000111684keywords:
subject
Has Abstractpub_date
1992-01-01 00:00:00pages
362-8issue
5-6eissn
0378-5866issn
1421-9859journal_volume
14pub_type
杂志文章abstract：:Systemic creatine (Cr) supplementation increases brain phosphocreatine (PCr) and prevents hypoxic seizures in 15-day-old rabbits. Between 5 and 30 days of age during normal development, rabbit gray matter mitochondrial creatine kinase (Mi-CK) increases 400% while cytosolic CK (BB-CK) increases 60%. In white matter, bo...
journal_title：Developmental neuroscience
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journal_title：Developmental neuroscience
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pub_type： 杂志文章,评审
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更新日期：2007-01-01 00:00:00
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journal_title：Developmental neuroscience
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doi：10.1159/000017298
更新日期：1998-01-01 00:00:00
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journal_title：Developmental neuroscience
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journal_title：Developmental neuroscience
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journal_title：Developmental neuroscience
pub_type： 杂志文章
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更新日期：1978-01-01 00:00:00
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journal_title：Developmental neuroscience
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更新日期：2016-01-01 00:00:00
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doi：10.1159/000017452
更新日期：2000-01-01 00:00:00
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journal_title：Developmental neuroscience
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更新日期：1990-01-01 00:00:00
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journal_title：Developmental neuroscience
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更新日期：2014-01-01 00:00:00
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journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000111682
更新日期：1992-01-01 00:00:00
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journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000452833
更新日期：2017-01-01 00:00:00
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journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000112695
更新日期：1982-01-01 00:00:00
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journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000111201
更新日期：1997-01-01 00:00:00
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journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000490289
更新日期：2018-01-01 00:00:00
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journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000017310
更新日期：1998-01-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1159/000329420
更新日期：2011-01-01 00:00:00
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journal_title：Developmental neuroscience
pub_type： 杂志文章,评审
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更新日期：1991-01-01 00:00:00
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journal_title：Developmental neuroscience
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doi：10.1159/000111951
更新日期：1988-01-01 00:00:00
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journal_title：Developmental neuroscience
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doi：10.1159/000017339
更新日期：1998-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1159/000017352
更新日期：1998-01-01 00:00:00
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journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000105473
更新日期：2007-01-01 00:00:00
abstract：:The neonatal rat model of unilateral cerebral hypoxia-ischemia (HI) is commonly used to test the efficacy of therapeutic strategies for prevention or treatment of stroke in the immature brain. Traditionally neuroprotection has been defined as reduction in tissue injury; there is growing interest in complementary funct...
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pub_type： 杂志文章
doi：10.1159/000075665
更新日期：2003-11-01 00:00:00
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journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000112301
更新日期：1985-01-01 00:00:00
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journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000111289
更新日期：1995-01-01 00:00:00
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journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000017364
更新日期：1999-01-01 00:00:00
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journal_title：Developmental neuroscience
pub_type： 杂志文章
doi：10.1159/000017429
更新日期：2000-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1159/000111318
更新日期：1993-01-01 00:00:00
