Glial disturbances in isolated neocortex: evidence from immunohistochemistry of intraocular grafts.

abstract：:Adult GM2 gangliosidosis is a rare autosomal recessive disease with widely varying neurological and psychiatric manifestations. It is caused by marked deficiency, but not total absence, of beta-hexosaminidase (Hex) A, due to a single base change in the alpha-subunit gene of Hex, resulting in a substitution of Ser for ...

journal_title：Developmental neuroscience

authors： Navon R

更新日期：1991-01-01 00:00:00

abstract：:All known actions of cAMP in the brain require cAMP-dependent protein kinase (cAMPdPK), which consists of regulatory (R) and catalytic (C) subunits (R2C2). Using homologous rat cDNAs for all known cAMPdPK subunit isoforms found in the brain (RI alpha, RI beta, RII alpha, RII beta, C alpha, C beta) we observe that, in ...

journal_title：Developmental neuroscience

authors： Massa JS,Walker PS,Moser DR,Fellows RE,Maurer RA

更新日期：1991-01-01 00:00:00

abstract：:We have previously shown that a single intracranial injection of apotransferrin (aTf) in neonatal rats produces an accelerated mylinogenesis and increases the expression of certain myelin proteins such as myelin basic protein (MBP). In the present work, we studied the effects of aTf upon oligodendrocyte progenitor cel...

journal_title：Developmental neuroscience

authors： Paez PM,Marta CB,Moreno MB,Soto EF,Pasquini JM

更新日期：2002-01-01 00:00:00

abstract：:This study investigated the time of expression of two endothelial cell adhesion molecules, ICAM-1/CD54 and PECAM-1/CD31 in the developing postpartum mouse blood-brain barrier (BBB). Immunoultrastructural studies demonstrated that both adhesion molecules are initially expressed primarily on the luminal endothelial cell...

journal_title：Developmental neuroscience

authors： Lossinsky AS,Wisniewski HM

更新日期：1998-01-01 00:00:00

abstract：:We have previously shown that lipopolysaccharide (LPS) sensitizes the immature rat brain to subsequent hypoxic-ischemic (HI) injury; however, the underlying mechanisms remain unclear. In this study, we examined the role of glucose in the sensitizing effects of LPS and lipoteichoic acid (LTA) in combination with HI in ...

journal_title：Developmental neuroscience

authors： Eklind S,Arvidsson P,Hagberg H,Mallard C

更新日期：2004-01-01 00:00:00

abstract：:The distal segments of the crush-injured and permanently transected sciatic nerve provide models to study Schwann cell activity in the presence and absence of Schwann cell-axonal contact, respectively. We examined the quantity and quality of transcript coding for the myelin-associated glycoprotein (MAG) over a 3-week ...

journal_title：Developmental neuroscience

authors： Gupta SK,Poduslo JF,Dunn R,Roder J,Mezei C

更新日期：1990-01-01 00:00:00

abstract：:Cell polarity is one of the most basic properties of all normal cells and loss of polarity is a hallmark of cancer. While multiple proteins have been implicated in the maintenance of cell polarity, the functionally related neoplastic tumor suppressors Lethal giant larvae (Lgl), Scribble and Disks large comprise a uniq...

journal_title：Developmental neuroscience

authors： Vasioukhin V

更新日期：2006-01-01 00:00:00

abstract：:Preadolescent animals display protracted hormonal stress responses mediated by the hypothalamic-pituitary-adrenal (HPA) axis compared to adults. Though the mechanisms that underlie this shift in stress reactivity are unknown, reduced glucocorticoid-dependent negative feedback on the HPA axis has been posited to contri...

journal_title：Developmental neuroscience

authors： Dziedzic N,Ho A,Adabi B,Foilb AR,Romeo RD

更新日期：2014-01-01 00:00:00

abstract：:While extracellular signals play a major role in brain neurogenesis, little is known about the cell cycle machinery underlying mitogen stimulation of precursor proliferation. Current models suggest that the D cyclins function as primary sensors of extracellular mitogens. Here we define the mechanisms by which basic fi...

journal_title：Developmental neuroscience

authors： Li B,DiCicco-Bloom E

更新日期：2004-03-01 00:00:00

abstract：:The effect of undernutrition on the activity of glutamate decarboxylase (GAD) and choline acetyltransferase (ChAc) (markers for the GABA-ergic and the cholinergic transmitter system, respectively) was studied in various parts of the rat brain at the age of 10, 15 and 21 days, and at day 54 following 33 days of rehabil...

journal_title：Developmental neuroscience

authors： Patel AJ,del Vecchio M,Atkinson DJ

更新日期：1978-01-01 00:00:00

abstract：:Evidence from retroviral marking techniques and immortalized cell lines indicates that multipotential stem cells exist in many areas of the developing central nervous system. However, the factors that influence the commitment of these stem cells into distinct neuronal or glial lineages are not known. We have created a...

journal_title：Developmental neuroscience

authors： Marone M,Quiñones-Jenab V,Meiners S,Nowakowski RS,Ho SY,Geller HM

更新日期：1995-01-01 00:00:00

abstract：:The neonatal rat model of unilateral cerebral hypoxia-ischemia (HI) is commonly used to test the efficacy of therapeutic strategies for prevention or treatment of stroke in the immature brain. Traditionally neuroprotection has been defined as reduction in tissue injury; there is growing interest in complementary funct...

journal_title：Developmental neuroscience

authors： Grow JL,Liu YQ,Barks JD

更新日期：2003-11-01 00:00:00

abstract：:Neurotoxicological studies have indicated that L-glutamate exhibits more pronounced effects on the preoptic area (POA) neurons of male rats than on those of females in the neonatal period. However, no information has previously been available as to whether or not such sexual dimorphism also exists for the effects of g...

journal_title：Developmental neuroscience

authors： Hsu C,Hsieh YL,Ho ML,Hsu HK,Yu JY

更新日期：2001-01-01 00:00:00

abstract：:Prenatal cocaine exposure results in behavioral abnormalities throughout development in rats, but little is known regarding the biological mechanisms underlying these abnormalities. Pregnant rats received subcutaneous twice-daily injections (1 ml/kg) of normal saline or 15 mg/kg of cocaine hydrochloride throughout ges...

journal_title：Developmental neuroscience

authors： Johns JM,Lubin DA,Lieberman JA,Lauder JM

更新日期：2002-01-01 00:00:00

abstract：:Ethanol inhibition of L1-mediated cell adhesion may contribute to the spectrum of neurological, behavioral and morphological abnormalities associated with prenatal ethanol exposure. We showed previously that the neuroprotective peptides NAPVSIPQ (NAP) and SALLRSIPA (SAL) antagonize ethanol inhibition of L1 adhesion an...

journal_title：Developmental neuroscience

authors： Chen SY,Charness ME,Wilkemeyer MF,Sulik KK

更新日期：2005-01-01 00:00:00

abstract：:Autism spectrum disorder (ASD) comprises a group of neurodevelopmental disorders characterized by social deficits and stereotyped behaviors. While several theories have emerged, the pathogenesis of ASD remains unknown. Although studies report dopamine signaling abnormalities in autistic patients, a coherent dopamine h...

journal_title：Developmental neuroscience

authors： Pavăl D

更新日期：2017-01-01 00:00:00

abstract：:Various abnormalities in frontal and striatal regions have been reported in children with prenatal alcohol and/or methamphetamine exposure. In a recent fMRI study, we observed a correlation between accuracy on a working-memory task and functional activation in the putamen in children with prenatal methamphetamine and ...

journal_title：Developmental neuroscience

authors： Roussotte FF,Rudie JD,Smith L,O'Connor MJ,Bookheimer SY,Narr KL,Sowell ER

更新日期：2012-01-01 00:00:00

abstract：:Although multipotent progenitor cells capable of generating neurons, astrocytes and oligodendrocytes are present within the germinal zones of the brain throughout embryonic, postnatal and adult life, the different neural cell types are generated within discrete temporospatial developmental windows. This might suggest ...

journal_title：Developmental neuroscience

authors： Mehler MF,Mabie PC,Zhu G,Gokhan S,Kessler JA

更新日期：2000-01-01 00:00:00

abstract：:Maternal infection during pregnancy increases the risk of neurobehavioral problems in offspring. Evidence from rodent models indicates that the maternal immune response to infection can alter fetal brain development, particularly in the hippocampus. However, information on the effects of maternal viral infection on fe...

journal_title：Developmental neuroscience

authors： Antonson AM,Balakrishnan B,Radlowski EC,Petr G,Johnson RW

更新日期：2018-01-01 00:00:00

abstract：:In the presence of nerve growth factor (NGF) PC12 pheochromocytoma cells develop properties of sympathetic neurons and extend long microtubule-containing neurites. PC12 cell microtubule protein was isolated using an assembly and disassembly procedure, either directly from an unlabeled cell extract or by copolymerizati...

journal_title：Developmental neuroscience

authors： Richter-Landsberg C,Landreth GE,Shooter EM

更新日期：1983-01-01 00:00:00

abstract：:A total of 216 male and female albino Wistar rats (Rattus norvegicus) between 10 and 60 days old from 42 litters were studied to determine mast cell characteristics within the thalamus. Whereas the mean numbers of mast cells within both the parenchyma and leptomeninges (combined) did not change appreciably after 15 da...

journal_title：Developmental neuroscience

authors： Persinger MA

更新日期：1981-01-01 00:00:00

abstract：:The postnatal developmental expression and the distribution of the glutamate transporters (GLAST, GLT-1 and EAAC1) were analyzed in rat vestibular nuclei (VN), at birth and during the following 4 weeks. Analyses were performed using reverse transcriptase-polymerase chain reaction and immunoblotting of GLAST, GLT-1 and...

journal_title：Developmental neuroscience

authors： Devau G,Plachez C,Puyal J,Pierrot N,Ventéo S,Raymond J

更新日期：2003-09-01 00:00:00

abstract：:Prenatal fever could result in brain function impairments in the offspring. The present study investigated the effect of interleukin-6 (IL-6)-induced maternal fever on the offspring and the involvement of connexin 36 in this process. Pregnant C57BL/6J mice were injected with IL-6 on gestational day 15. The levels of i...

journal_title：Developmental neuroscience

authors： Wang R,Yang Y,Xiao M,Guo B,Liu W,Wang H

更新日期：2019-01-01 00:00:00

abstract：:Systemic creatine (Cr) supplementation increases brain phosphocreatine (PCr) and prevents hypoxic seizures in 15-day-old rabbits. Between 5 and 30 days of age during normal development, rabbit gray matter mitochondrial creatine kinase (Mi-CK) increases 400% while cytosolic CK (BB-CK) increases 60%. In white matter, bo...

journal_title：Developmental neuroscience

authors： Kekelidze T,Khait I,Togliatti A,Holtzman D

更新日期：2000-09-01 00:00:00

abstract：:Radiotherapy is an effective treatment strategy in the treatment of brain tumors, but it is also a major cause of long-term complications, especially in survivors of pediatric brain tumors. Cognitive decline caused by cranial radiotherapy is thought, at least partly, to depend on injury to stem and progenitor cells in...

journal_title：Developmental neuroscience

authors： Roughton K,Andreasson U,Blomgren K,Kalm M

更新日期：2013-01-01 00:00:00

abstract：:The long noncoding RNA MSNP1AS (moesin pseudogene 1, antisense) is a functional element that was previously associated with autism spectrum disorder (ASD) with genome-wide significance. Expression of MSNP1AS was increased 12-fold in the cerebral cortex of individuals with ASD and 22-fold in individuals with a genome-w...

journal_title：Developmental neuroscience

authors： DeWitt JJ,Hecht PM,Grepo N,Wilkinson B,Evgrafov OV,Morris KV,Knowles JA,Campbell DB

更新日期：2016-01-01 00:00:00

abstract：:Excitotoxicity plays a key role during insults to the developing brain such as neonatal encephalopathy, stroke, and encephalopathy of prematurity. Such insults affect many thousands of infants each year. Excitotoxicity causes frank lesions due to cell death and gliosis and disturbs normal developmental process, leadin...

journal_title：Developmental neuroscience

authors： Blaise BJ,Schwendimann L,Chhor V,Degos V,Hodson MP,Dallmann G,Keller M,Gressens P,Fleiss B

更新日期：2017-01-01 00:00:00

abstract：:Our previous studies of H218, a sphingosine 1-phosphate (S1P) receptor and a member of the G-protein-coupled receptor superfamily, suggest that it may participate in mammalian nervous system development. Thus, brain levels of H218 mRNA are higher during early neurogenesis than postnatally. In addition, embryonic H218 ...

journal_title：Developmental neuroscience

authors： MacLennan AJ,Devlin BK,Marks L,Gaskin AA,Neitzel KL,Lee N

更新日期：2000-01-01 00:00:00

abstract：:As a step toward using two closely related members of the nuclear receptor family, RORalpha and RORbeta, as markers and tools for genetic manipulations in mouse forebrain, we have used in situ hybridization to analyze their expression from E10.5 to P7. At later embryonic and early postnatal ages, RORalpha expression i...

journal_title：Developmental neuroscience

authors： Nakagawa Y,O'Leary DD

更新日期：2003-03-01 00:00:00

abstract：:Chick embryo retina neurons in culture extend neurites and form synapses. Seven different culture substrates were compared to determine which culture surface would produce the best neuronal survival and neurite extension. The order of survival of retina neurons during 7 days of culture is salt-precipitated collagen gr...

journal_title：Developmental neuroscience

authors： Thompson JM,Pelto DJ

更新日期：1982-01-01 00:00:00