Oligodendrocyte Progenitor Cell Proliferation and Fate after White Matter Stroke in Juvenile and Adult Mice.

abstract：:The cell line MN9D, a fusion of embryonic ventral mesencephalic and neuroblastoma cells, is extensively used as a model of dopamine (DA) neurons because it expresses tyrosine hydroxylase and synthesizes and releases DA. These cells are also used to test mechanisms and potential therapeutics relevant to the loss of DA ...

journal_title：Developmental neuroscience

authors： Rick CE,Ebert A,Virag T,Bohn MC,Surmeier DJ

更新日期：2006-01-01 00:00:00

abstract：:Rats were exposed to mild hyperoxia and hypoxia by the administration of oxygen/air and nitrogen/air mixtures through plastic tubing held close to their snouts for periods of 3 min. Changes in tissue oxygen were monitored at an implanted carbon paste electrode; local cerebral blood flow (rCBF) at an implanted platinum...

journal_title：Developmental neuroscience

authors： Lowry JP,Demestre M,Fillenz M

更新日期：1998-01-01 00:00:00

abstract：:Ethanol inhibition of L1-mediated cell adhesion may contribute to the spectrum of neurological, behavioral and morphological abnormalities associated with prenatal ethanol exposure. We showed previously that the neuroprotective peptides NAPVSIPQ (NAP) and SALLRSIPA (SAL) antagonize ethanol inhibition of L1 adhesion an...

journal_title：Developmental neuroscience

authors： Chen SY,Charness ME,Wilkemeyer MF,Sulik KK

更新日期：2005-01-01 00:00:00

abstract：:Creatine kinase (CK) isoenzymes, with emphasis on the mitochondrial CK isoenzymes, were characterized and localized in chicken cerebellum. Chicken cerebellum extracts analyzed by two-dimensional gels, using antipeptide antibodies specific for sarcomeric muscle-type mitochondrial CK (Mib-CK) and revealed the presence o...

journal_title：Developmental neuroscience

authors： Kaldis P,Hemmer W,Zanolla E,Holtzman D,Wallimann T

更新日期：1996-01-01 00:00:00

abstract：:Disorders primarily affecting the nervous system comprise approximately one third of all established Mendelian genetic diseases in man. Recombinant DNA technology provides new approaches to the diagnosis and elucidation of the molecular pathology of these disorders. For a small but increasing number of disorders the D...

journal_title：Developmental neuroscience

authors： Hayden MR,Nichols JL

更新日期：1983-01-01 00:00:00

abstract：:Developmental expression of neutral monoglycosylceramides (MGCs) has been examined in rat brain from embryonic day 15 (E15) to postnatal day 30 (P30) and adulthood. To this point, glucosylceramide (GlcCer) is the only MGC that has been characterized in embryonic brain. Galactosylceramide (GalCer) appears at P1, increa...

journal_title：Developmental neuroscience

authors： Dasgupta S,Everhart MB,Bhat NR,Hogan EL

更新日期：1997-01-01 00:00:00

abstract：:There are distinct symptoms for attention deficit hyperactivity disorder (ADHD) at different ages. To explore the developmental mechanism of ADHD from childhood to adolescence, patients from different age groups with ADHD drawn from a large dataset should be investigated. In this study, we hypothesized that there are ...

journal_title：Developmental neuroscience

authors： Tang C,Wei Y,Zhao J,Nie J

更新日期：2018-01-01 00:00:00

abstract：:Perinatal asphyxia is a leading cause of brain injury in neonates, occurring in 2-4 per 1,000 live births, and there are limited treatment options. Because of their similarity to humans, nonhuman primates are ideal for performing preclinical tests of safety and efficacy for neurotherapeutic interventions. We previousl...

journal_title：Developmental neuroscience

authors： Jacobson Misbe EN,Richards TL,McPherson RJ,Burbacher TM,Juul SE

更新日期：2011-01-01 00:00:00

abstract：:The proximodistal axonal transport of choline acetyltransferase (ChAc) has been studied in the chick sciatic nerve in the absence of any experimental manipulation. The phenomenon utilized by us is a physiological transient fall in the activity of ChAc. This fall occurs in most areas of the chick central nervous system...

journal_title：Developmental neuroscience

authors： Giacobini G,Cannas M,Panattoni GL,Filogamo G

更新日期：1979-01-01 00:00:00

abstract：:Apoptosis contributes greatly to the morphological and biochemical features of cell death after neonatal cerebral hypoxia-ischemia (HI), making this mode of cell death a promising therapeutic target. We previously showed that 10 mg/kg of the caspase inhibitor Q-VD-OPh at the onset of and immediately after HI on postna...

journal_title：Developmental neuroscience

authors： Han W,Sun Y,Wang X,Zhu C,Blomgren K

更新日期：2014-01-01 00:00:00

abstract：:In the era of therapeutic hypothermia, reliable preclinical studies are integral to successfully identify neuroprotective strategies to further improve outcomes of encephalopathy at term. We reviewed preclinical neuroprotection studies reported between January 2014 and June 2016 to assess the use of effective temperat...

journal_title：Developmental neuroscience

authors： Galinsky R,Dean JM,Lear CA,Davidson JO,Dhillon S,Wassink G,Bennet L,Gunn AJ

更新日期：2017-01-01 00:00:00

abstract：:Nogo is a member of the reticulon family. Our understanding of the physiological functions of the Nogo-A protein has grown over the last few years, and this molecule is now recognized as one of the most important axonal regrowth inhibitors present in central nervous system (CNS) myelin. Nogo-A plays other important ro...

journal_title：Developmental neuroscience

authors： Haybaeck J,Llenos IC,Dulay RJ,Bettermann K,Miller CL,Wälchli T,Frei K,Virgintino D,Rizzi M,Weis S

更新日期：2012-01-01 00:00:00

abstract：:We investigated the effects of perinatal hypoxia-ischemia (HI) on brain injury and neurological functional outcome at postnatal day (P)30 through P90. HI was induced by exposing P9 mice to 8% O(2) for 55 min using the Vannucci HI model. Following HI, mice were treated with either vehicle control or Na(+)/H(+) exchange...

journal_title：Developmental neuroscience

authors： Cengiz P,Uluc K,Kendigelen P,Akture E,Hutchinson E,Song C,Zhang L,Lee J,Budoff GE,Meyerand E,Sun D,Ferrazzano P

更新日期：2011-01-01 00:00:00

abstract：:In this study, the proliferative activity of cultured chick neuroblasts exposed to high or low concentrations of fetal calf serum (FCS) was investigated. Different experimental evidences showed that the first 2-3 days of culture correspond to a period of neuronal proliferation in our culture conditions, whereas contam...

journal_title：Developmental neuroscience

authors： Barakat I,Labourdette G,Sensenbrenner M

更新日期：1983-01-01 00:00:00

abstract：:The myelin-associated glycoprotein (MAG) in primary cultures of oligodendrocytes is subject to phosphorylation in the absence of neurons. The positive response of this phosphorylation to vanadate suggests that one of the modified sites in MAG is phosphotyrosine. We found that phosphorylation was enhanced by brief trea...

journal_title：Developmental neuroscience

authors： Bambrick LL,Braun PE

更新日期：1991-01-01 00:00:00

abstract：:In this study we have examined the susceptibility of the mitochondrial respiratory chain of astrocytes and astrocytes depleted of glutathione to peroxynitrite exposure. Astrocytes, as reported previously by us, appeared resistant to the actions of peroxynitrite. In contrast, depletion (-94%) of astrocytic glutathione ...

journal_title：Developmental neuroscience

authors： Barker JE,Bolaños JP,Land JM,Clark JB,Heales SJ

更新日期：1996-01-01 00:00:00

abstract：:Parallel developmental studies of central nervous system myelin proteins and morphology (postnatal days 15-118; P15-118) confirm qualitative similarities but substantial quantitative differences between homozygous mld mice with Billings-Gagliardi and Wolf's 'USA' versus Matthieu's 'Swiss' genetic backgrounds. The USA ...

journal_title：Developmental neuroscience

authors： Billings-Gagliardi S,Tosic M,Matthieu JM,Kirschner DA,Wolf MK

更新日期：1991-01-01 00:00:00

abstract：:Prior studies suggest that non-canonical proteolipid protein (PLP) gene expression occurs during development in non-myelinating neurons as well as myelinating oligodendroglia in mammalian brain. To assess this possibility in neostriatum, a region of uncertain PLP gene expression in neurons, morphological and electroph...

journal_title：Developmental neuroscience

authors： Fulton D,Paez P,Spreur V,Handley V,Colwell CS,Campagnoni A,Fisher R

更新日期：2011-01-01 00:00:00

abstract：:The activity of glycerophosphorylcholine phosphodiesterases was determined in the mesencephalon, diencephalon, cerebral hemispheres, cerebellum and olfactory bulb during postnatal development from P5 to P70 of rat brain. These activities are low and gradually increase to near adult levels by the end of the first postn...

journal_title：Developmental neuroscience

authors： Kanfer JN,McCartney DG

更新日期：1989-01-01 00:00:00

abstract：:We have used whole-cell and single-channel recording techniques to investigate the electrophysiological properties of cultured ovine oligodendrocytes (OLGs). Our studies have led to the following conclusions. (1) Cultured mature OLGs express a variety of voltage-dependent K+ conductances including an outward current t...

journal_title：Developmental neuroscience

authors： Soliven B,Szuchet S,Arnason BG,Nelson DJ

更新日期：1989-01-01 00:00:00

abstract：:The postnatal development of the complexes of the electron transport chain in mitochondria isolated from rat brain synaptosomes was investigated. Synaptosomal brain mitochondria were isolated from rats aged 10-60 days, and the activities of mitochondrial complex I, complex II-III, complex IV and complex V were measure...

journal_title：Developmental neuroscience

authors： Almeida A,Brooks KJ,Sammut I,Keelan J,Davey GP,Clark JB,Bates TE

更新日期：1995-01-01 00:00:00

abstract：:The cerebromicrovasculature of immature mice ranging in age from 1-24 days after birth was studied by electron microscopy. A micromanipulator apparatus enabled us to facilitate direction of a needle cannula and injection into leg veins or hearts with horseradish peroxidase (HRP) or ferritin (anionic and cationic) trac...

journal_title：Developmental neuroscience

authors： Lossinsky AS,Vorbrodt AW,Wisniewski HM

更新日期：1986-01-01 00:00:00

abstract：:Myelinogenesis in different brain parts of trout was studied comparatively by means of histochemistry and biochemistry. A more detailed approach, including ultrastructural analysis, to characterize this important differentiation process, particularly in the optic tectum, revealed a good correlation between the structu...

journal_title：Developmental neuroscience

authors： Jeserich G

更新日期：1981-01-01 00:00:00

abstract：:In cultured glial cells from chick embryonic brain, both influx and efflux of 42K+ and 22Na+ are dependent on the external Ca++ and concentration ([Ca++]0) between 2 and 0.1 mM although intracellular concentrations of K+ ([K+]i) and Na+ ([Na+]i) do not change. Only a reduction of [Ca++]0 below 0.1 mM results in both a...

journal_title：Developmental neuroscience

authors： Latzkovits L,Rimanóczy A,Juhász A,Torday C,Sensenbrenner M

更新日期：1982-01-01 00:00:00

abstract：:Prenatal cocaine exposure results in behavioral abnormalities throughout development in rats, but little is known regarding the biological mechanisms underlying these abnormalities. Pregnant rats received subcutaneous twice-daily injections (1 ml/kg) of normal saline or 15 mg/kg of cocaine hydrochloride throughout ges...

journal_title：Developmental neuroscience

authors： Johns JM,Lubin DA,Lieberman JA,Lauder JM

更新日期：2002-01-01 00:00:00

abstract：:Neonatal stroke leads to mortality and severe morbidity, but there is no effective treatment currently available. Erythropoietin (EPO) has been shown to promote cytoprotection and neurogenesis and decrease subventricular zone morphologic changes following brain injury. The long-term cellular response to EPO has not be...

journal_title：Developmental neuroscience

authors： Gonzalez FF,McQuillen P,Mu D,Chang Y,Wendland M,Vexler Z,Ferriero DM

更新日期：2007-01-01 00:00:00

abstract：:The postnatal developmental expression and the distribution of the glutamate transporters (GLAST, GLT-1 and EAAC1) were analyzed in rat vestibular nuclei (VN), at birth and during the following 4 weeks. Analyses were performed using reverse transcriptase-polymerase chain reaction and immunoblotting of GLAST, GLT-1 and...

journal_title：Developmental neuroscience

authors： Devau G,Plachez C,Puyal J,Pierrot N,Ventéo S,Raymond J

更新日期：2003-09-01 00:00:00

abstract：:In the presence of nerve growth factor (NGF) PC12 pheochromocytoma cells develop properties of sympathetic neurons and extend long microtubule-containing neurites. PC12 cell microtubule protein was isolated using an assembly and disassembly procedure, either directly from an unlabeled cell extract or by copolymerizati...

journal_title：Developmental neuroscience

authors： Richter-Landsberg C,Landreth GE,Shooter EM

更新日期：1983-01-01 00:00:00

abstract：:Dissociated brain cell cultures are a useful model for investigating development and differentiation of oligodendrocytes in vitro. The current studies compare the developmental patterns of expression for oligodendrocyte lineage/myelin markers in both primary and secondary oligodendrocyte cultures derived from mouse an...

journal_title：Developmental neuroscience

authors： Duchala CS,Asotra K,Macklin WB

更新日期：1995-01-01 00:00:00

abstract：:The expression of voltage-gated potassium channels plays an important role in the acquisition of membrane excitability in neurons. We examined the expression pattern of genes in developing cerebellar granule neurons in vivo and in vitro. In situ hybridization of Kv3.1 mRNA demonstrated that the gene was expressed at h...

journal_title：Developmental neuroscience

authors： Shibata R,Wakazono Y,Nakahira K,Trimmer JS,Ikenaka K

更新日期：1999-01-01 00:00:00