Abstract:
:Insulin binding was measured on crude mitochondrial or plasma membranes prepared from different rat brain regions during postnatal development. In the cerebral cortex and brainstem, insulin binding decreased 60-70% between birth and the adult period. In the cerebellum, insulin binding doubled in the first 10 postnatal days and then decreased 40% in the adult, while in the olfactory bulb, insulin binding changed little during postnatal development. Postnatal reductions of insulin binding in cerebral cortex and brainstem were from a loss of binding sites and not from a change in binding affinity. Of the major postnatal developmental processes, maximal insulin binding was most closely associated with neuronogenesis, less closely with gliogenesis and not with synaptogenesis, neural process formation or myelination.
journal_name
Dev Neuroscijournal_title
Developmental neuroscienceauthors
Marks JL,Eastman CJdoi
10.1159/000111863subject
Has Abstractpub_date
1990-01-01 00:00:00pages
349-58issue
6eissn
0378-5866issn
1421-9859journal_volume
12pub_type
杂志文章abstract::The gene responsible for the audiogenic seizure (AGS) phenotype in Frings mice, which was identified and originally designated Mass1, is now referred to as Mgr1. Although the function of the gene product is not known, the expression pattern suggests a role in the developing CNS. Hearing impairment is often observed in...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000086712
更新日期:2005-01-01 00:00:00
abstract::The metabolism of [1-13C]D-glucose by astrocytes, neurons and mixed astroglial/neuronal cultures derived from the striatum of fetal rats was studied using NMR. Metabolic activity was studied in resting and depolarized cells (55 mM K+), with dibutyryl cyclic-AMP added to the medium to promote cell differentiation, and ...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111346
更新日期:1993-01-01 00:00:00
abstract::Metabolism of glutamate and glutamine in cultured mouse cerebral cortical astrocytes has been investigated using either radioactively labelled (14C) amino acids or 13C-labelled amino acids combined with NMR spectroscopy of cell extracts and lyophilyzed incubation media. Using [U-13C]glutamate it has been shown that in...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000111356
更新日期:1993-01-01 00:00:00
abstract::The activity of glycerophosphorylcholine phosphodiesterases was determined in the mesencephalon, diencephalon, cerebral hemispheres, cerebellum and olfactory bulb during postnatal development from P5 to P70 of rat brain. These activities are low and gradually increase to near adult levels by the end of the first postn...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111882
更新日期:1989-01-01 00:00:00
abstract::In this study, the proliferative activity of cultured chick neuroblasts exposed to high or low concentrations of fetal calf serum (FCS) was investigated. Different experimental evidences showed that the first 2-3 days of culture correspond to a period of neuronal proliferation in our culture conditions, whereas contam...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112344
更新日期:1983-01-01 00:00:00
abstract::Neural stem cells are attracting enormous attention in regenerative medicine due to their ability to self-renew and differentiate into the cell lineages that constitute the central nervous system. However, little is known about the mechanism underlying the regulation of their redox environment, which is essential for ...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000493009
更新日期:2018-01-01 00:00:00
abstract::Various abnormalities in frontal and striatal regions have been reported in children with prenatal alcohol and/or methamphetamine exposure. In a recent fMRI study, we observed a correlation between accuracy on a working-memory task and functional activation in the putamen in children with prenatal methamphetamine and ...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000336242
更新日期:2012-01-01 00:00:00
abstract::In vertebrate species, the neuropeptide oxytocin (OT) has been implicated in neural and behavioral development. Although several OT-like peptides have been characterized in invertebrate species, the ontogenesis of the OT-like system has not yet been described in these species. Thus, the aim of the present study was to...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000235942
更新日期:2010-03-01 00:00:00
abstract::The neonatal brain appears to be selectively vulnerable to oxidative stress. Several potential mechanisms associated with altered reactive oxygen species metabolism would explain the increased susceptibility. They include increased accumulation of hydrogen peroxide with subsequent neurotoxicity. This enhanced neurotox...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000046143
更新日期:2001-01-01 00:00:00
abstract::We have previously provided evidence that ferritin binds selectively to white matter tracts in adult mouse and human brains. In cell culture experiments, ferritin binding is specifically localized to oligodendrocytes. The goal of the present study is to test the hypothesis that the developmental pattern for ferritin b...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000065704
更新日期:2002-01-01 00:00:00
abstract::All known actions of cAMP in the brain require cAMP-dependent protein kinase (cAMPdPK), which consists of regulatory (R) and catalytic (C) subunits (R2C2). Using homologous rat cDNAs for all known cAMPdPK subunit isoforms found in the brain (RI alpha, RI beta, RII alpha, RII beta, C alpha, C beta) we observe that, in ...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112140
更新日期:1991-01-01 00:00:00
abstract::Evidence from retroviral marking techniques and immortalized cell lines indicates that multipotential stem cells exist in many areas of the developing central nervous system. However, the factors that influence the commitment of these stem cells into distinct neuronal or glial lineages are not known. We have created a...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111301
更新日期:1995-01-01 00:00:00
abstract::The neonatal rat model of unilateral cerebral hypoxia-ischemia (HI) is commonly used to test the efficacy of therapeutic strategies for prevention or treatment of stroke in the immature brain. Traditionally neuroprotection has been defined as reduction in tissue injury; there is growing interest in complementary funct...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000075665
更新日期:2003-11-01 00:00:00
abstract::The distribution of the noradrenergic system within the rat cerebellar cortex following low-level X-irradiation was studied using tyrosine hydroxylase immunocytochemistry. X-Irradiation treatments consisted of 1, 3, or 5 successive daily dose beginning on postnatal day 1. When studied 24 h after the last exposure, a d...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112092
更新日期:1994-01-01 00:00:00
abstract::Neurotoxicological studies have indicated that L-glutamate exhibits more pronounced effects on the preoptic area (POA) neurons of male rats than on those of females in the neonatal period. However, no information has previously been available as to whether or not such sexual dimorphism also exists for the effects of g...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000048726
更新日期:2001-01-01 00:00:00
abstract::Fragile X syndrome (FXS) is a neurodevelopmental disorder characterized by intellectual disability, sensory hypersensitivity, and high incidences of autism spectrum disorders and epilepsy. These phenotypes are suggestive of defects in neural circuit development and imbalances in excitatory glutamatergic and inhibitory...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000329420
更新日期:2011-01-01 00:00:00
abstract::We have previously shown that a single intracranial injection of apotransferrin (aTf) in neonatal rats produces an accelerated mylinogenesis and increases the expression of certain myelin proteins such as myelin basic protein (MBP). In the present work, we studied the effects of aTf upon oligodendrocyte progenitor cel...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000064945
更新日期:2002-01-01 00:00:00
abstract::Dissociated brain cell cultures are a useful model for investigating development and differentiation of oligodendrocytes in vitro. The current studies compare the developmental patterns of expression for oligodendrocyte lineage/myelin markers in both primary and secondary oligodendrocyte cultures derived from mouse an...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111276
更新日期:1995-01-01 00:00:00
abstract::The fine structure of pituicytes was investigated between 15 days of fetal life and 120 days postnatum. Prior to the penetration of neurosecretory axons into the neural lobe a uniform population of undifferentiated pituicytes is presented. Coincidental with the first appearance of neurosecretory axons in the neural lo...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112744
更新日期:1981-01-01 00:00:00
abstract::Adrenoleukodystrophy (ALD) is an X-linked recessive disorder that affects mainly the nervous system white matter and the adrenal cortex. It is associated with an abnormal accumulation of saturated very long chain fatty acids and can be diagnosed by demonstrating an excess of these substances in plasma or red cells. Ou...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000112170
更新日期:1991-01-01 00:00:00
abstract::Steroid hormones have profound effects on vertebrate behaviors. Yet, in most cases we can neither identify the neurons responsible for particular behaviors nor how steroids alter their excitability. Electric fish emit sexually dimorphic electric organ discharges (EODs) the waveform of which may be altered by steroid t...
journal_title:Developmental neuroscience
pub_type: 杂志文章,评审
doi:10.1159/000111399
更新日期:1996-01-01 00:00:00
abstract::Developmental expression of neutral monoglycosylceramides (MGCs) has been examined in rat brain from embryonic day 15 (E15) to postnatal day 30 (P30) and adulthood. To this point, glucosylceramide (GlcCer) is the only MGC that has been characterized in embryonic brain. Galactosylceramide (GalCer) appears at P1, increa...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111201
更新日期:1997-01-01 00:00:00
abstract::Neurite outgrowth is dependent on the presence in neurites of assembled microtubules which consist of polymerized tubulin to which microtubule-associated proteins (MAPs) are bound. This study adds to previous evidence of the similarity between the high molecular weight MAPs, MAP1X, MAP1B and MAP5, and explains the dif...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111318
更新日期:1993-01-01 00:00:00
abstract::Perinatal asphyxia is a leading cause of brain injury in neonates, occurring in 2-4 per 1,000 live births, and there are limited treatment options. Because of their similarity to humans, nonhuman primates are ideal for performing preclinical tests of safety and efficacy for neurotherapeutic interventions. We previousl...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000327246
更新日期:2011-01-01 00:00:00
abstract::The distal segments of the crush-injured and permanently transected sciatic nerve provide models to study Schwann cell activity in the presence and absence of Schwann cell-axonal contact, respectively. We examined the quantity and quality of transcript coding for the myelin-associated glycoprotein (MAG) over a 3-week ...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111832
更新日期:1990-01-01 00:00:00
abstract::The cerebromicrovasculature of immature mice ranging in age from 1-24 days after birth was studied by electron microscopy. A micromanipulator apparatus enabled us to facilitate direction of a needle cannula and injection into leg veins or hearts with horseradish peroxidase (HRP) or ferritin (anionic and cationic) trac...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000112242
更新日期:1986-01-01 00:00:00
abstract::Quaking is a neurological mutation leading to pleiotropic phenotypic expression, the most prominent being disturbed myelin formation in the central nervous system (CNS) with minor abnormalities in the peripheral nervous system. Previous immunochemical measurements of glial fibrillary acidic protein (GFAP) revealed a m...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111682
更新日期:1992-01-01 00:00:00
abstract::The metabolism of [1, 2-13C2] acetate via the tricarboxylic acid (TCA) cycle leads to the formation of a number of key mass isotopomers of glutamate. The distribution of these isotopomers which is a function of pyruvate carboxylase, pyruvate dehydrogenase and pyruvate recycling was used to determine the relative anapl...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111442
更新日期:1996-01-01 00:00:00
abstract::Preadolescent animals display protracted hormonal stress responses mediated by the hypothalamic-pituitary-adrenal (HPA) axis compared to adults. Though the mechanisms that underlie this shift in stress reactivity are unknown, reduced glucocorticoid-dependent negative feedback on the HPA axis has been posited to contri...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000362873
更新日期:2014-01-01 00:00:00
abstract::Fragments of corpus callosum from P13 normal and jimpy (jp) mutant mice (containing only postmigrating precursors and differentiated oligodendrocytes (ODCs, some of them myelinating soon) have been transplanted into the thalamus of newborn shiverer (shi) mutant mice. The behaviour of transplanted ODCs has been assayed...
journal_title:Developmental neuroscience
pub_type: 杂志文章
doi:10.1159/000111654
更新日期:1992-01-01 00:00:00