Abstract:
:Neuroblastoma is a childhood cancer caused by the transformation of sympathoadrenal progenitors. By following the formation of tumors in homozygous TH-MYCN mice, an established mouse model of neuroblastoma, we were able to capture transformed cells prior to the formation of large, vascularized tumors in order to determine the responsiveness of cells to neurotrophic factors. We discovered that the ciliary neurotrophic factor (CNTF) receptor is abundantly expressed in tumor cells from these mice. Furthermore, CNTF - but not nerve growth factor, brain-derived nerve growth factor, neurotrophin 3, or glial cell line-derived neurotrophic factor - promoted neuronal differentiation and withdrawal from the cell cycle. Thus, the transformation of sympathoadrenal progenitors by MYCN overexpression differentially affects responsiveness to neurotrophic molecules.
journal_name
Dev Neuroscijournal_title
Developmental neuroscienceauthors
DeWitt J,Pappas A,Nishi Rdoi
10.1159/000365281subject
Has Abstractpub_date
2014-01-01 00:00:00pages
422-31issue
5eissn
0378-5866issn
1421-9859pii
000365281journal_volume
36pub_type
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journal_title:Developmental neuroscience
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