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CCR6 Defines Memory B Cell Precursors in Mouse and Human Germinal Centers, Revealing Light-Zone Location and Predominant Low Antigen Affinity.

Abstract：

:Memory B cells (MBCs) and plasma cells (PCs) constitute the two cellular outputs of germinal center (GC) responses that together facilitate long-term humoral immunity. Although expression of the transcription factor BLIMP-1 identifies cells undergoing PC differentiation, no such marker exists for cells committed to the MBC lineage. Here, we report that the chemokine receptor CCR6 uniquely marks MBC precursors in both mouse and human GCs. CCR6+ GC B cells were highly enriched within the GC light zone (LZ), were the most quiescent of all GC B cells, exhibited a cell-surface phenotype and gene expression signature indicative of an MBC transition, and possessed the augmented response characteristics of MBCs. MBC precursors within the GC LZ predominantly possessed a low affinity for antigen but also included cells from within the high-affinity pool. These data indicate a fundamental dichotomy between the processes that drive MBC and PC differentiation during GC responses.

journal_name

Immunity

journal_title

Immunity

authors

Suan D,Kräutler NJ,Maag JLV,Butt D,Bourne K,Hermes JR,Avery DT,Young C,Statham A,Elliott M,Dinger ME,Basten A,Tangye SG,Brink R

doi

10.1016/j.immuni.2017.11.022

subject

Has Abstract

pub_date

2017-12-19 00:00:00

pages

1142-1153.e4

issue

6

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(17)30523-X

journal_volume

47

pub_type

杂志文章

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