Abstract:
:Elevated inflammation in the female genital tract is associated with increased HIV risk. Cervicovaginal bacteria modulate genital inflammation; however, their role in HIV susceptibility has not been elucidated. In a prospective cohort of young, healthy South African women, we found that individuals with diverse genital bacterial communities dominated by anaerobes other than Gardnerella were at over 4-fold higher risk of acquiring HIV and had increased numbers of activated mucosal CD4+ T cells compared to those with Lactobacillus crispatus-dominant communities. We identified specific bacterial taxa linked with reduced (L. crispatus) or elevated (Prevotella, Sneathia, and other anaerobes) inflammation and HIV infection and found that high-risk bacteria increased numbers of activated genital CD4+ T cells in a murine model. Our results suggest that highly prevalent genital bacteria increase HIV risk by inducing mucosal HIV target cells. These findings might be leveraged to reduce HIV acquisition in women living in sub-Saharan Africa.
journal_name
Immunityjournal_title
Immunityauthors
Gosmann C,Anahtar MN,Handley SA,Farcasanu M,Abu-Ali G,Bowman BA,Padavattan N,Desai C,Droit L,Moodley A,Dong M,Chen Y,Ismail N,Ndung'u T,Ghebremichael MS,Wesemann DR,Mitchell C,Dong KL,Huttenhower C,Walker BD,Virgidoi
10.1016/j.immuni.2016.12.013subject
Has Abstractpub_date
2017-01-17 00:00:00pages
29-37issue
1eissn
1074-7613issn
1097-4180pii
S1074-7613(16)30519-2journal_volume
46pub_type
杂志文章相关文献
IMMUNITY文献大全abstract::The concept of an alternative pathway of macrophage activation has stimulated interest in its definition, mechanism, and functional significance in homeostasis and disease. We assess recent research in this field, argue for a restricted definition, and explore pathways by which the T helper 2 (Th2) cell cytokines inte...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2010.05.007
更新日期:2010-05-28 00:00:00
abstract::The Notch2 ligand DL1 is required for marginal zone B cell development. In this issue of Immunity, Tan et al. (2009) show that modification of Notch2 by Fringe enzymes is critical to maturing B cells for accessing DL1 on vascular endothelial cells. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2009.01.003
更新日期:2009-02-20 00:00:00
abstract::A unique subpopulation of spleen dendritic cells (DCs) that express the CD8 surface marker efficiently present phagocytosed antigens to CD8(+) T lymphocytes in a process called "crosspresentation," which initiates cytotoxic immune responses. We now show that the small GTPase Rac2 plays a critical role in antigen cross...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2009.01.013
更新日期:2009-04-17 00:00:00
abstract::We have identified RORgamma t, a novel, thymus-specific isoform of the orphan nuclear receptor RORgamma that is expressed predominantly in CD4+ CD8+ double-positive thymocytes. Ectopic expression of RORgamma t protects T cell hybridomas from activation-induced cell death by inhibiting the upregulation of Fas ligand. F...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80645-7
更新日期:1998-12-01 00:00:00
abstract::Different genetic alterations may lead to type I interferon (IFN) overproduction in human systemic lupus erythematosus (SLE). The increased bioavailability of type I IFN contributes to peripheral tolerance breakdown through the activation of immature myeloid dendritic cells (mDCs). IFN-matured mDCs activate autoreacti...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2006.08.010
更新日期:2006-09-01 00:00:00
abstract::Superantigens (SAgs) are proteins produced by pathogenic microbes to elicit potent, antigen-independent T cell responses that are believed to enhance the microbes' pathogenicity. Here we show that the human lymphotropic herpesvirus Epstein-Barr virus (EBV) transcriptionally activates the env gene of an endogenous retr...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(01)00210-2
更新日期:2001-10-01 00:00:00
abstract::Inflammation can activate self-reactive CD8(+) T cells and induce autoimmunity. Here we show in a CD8(+) T cell-mediated model of type 1 diabetes that CD4(+)CD25(+) Treg cells prevent beta cell destruction following localized inflammation in the islets of Langerhans. These Treg cells accumulate preferentially in the p...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(02)00279-0
更新日期:2002-02-01 00:00:00
abstract::Reactive oxygen species (ROS) are generated during T cell activation and serve a signaling function but can also be damaging. In this issue of Immunity, Zhang et al. (2016) show that miR-23a prevents ROS-elicited necrosis by suppressing cyclophilin D (PPIF), a regulator of ROS escape from mitochondria. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2016.02.027
更新日期:2016-03-15 00:00:00
abstract::Chronic inflammatory diseases represent an increasing medical burden, yet neither tools to predict the individual disease course nor causal cures are at hand. We discuss opportunities for systems medicine to derive precise, individualized disease models and outline the European consortium SYSCID as part of the roadmap...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2018.03.022
更新日期:2018-04-17 00:00:00
abstract::In this issue of Immunity, Mrdjen et al. (2018) use high-dimensional single-cell proteomics and high parametric mass cytometry to provide insight into the long-lasting issue of how to identify and characterize both resident and recruited leukocyte populations in healthy, aged, and diseased CNS. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2018.02.009
更新日期:2018-02-20 00:00:00
abstract::Gene-expression profiling has become a mainstay in immunology, but subtle changes in gene networks related to biological processes are hard to discern when comparing various datasets. For instance, conservation of the transcriptional response to sepsis in mouse models and human disease remains controversial. To improv...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2015.12.006
更新日期:2016-01-19 00:00:00
abstract::Latent and activated forms of Stat1 and Stat6 have been expressed and purified, enabling biochemical experiments relating to their functional activities. Stat1 bound to a phosphotyrosine peptide derived from the IFN gamma receptor with a KD of 50 nM, whereas Stat6 bound to an IL-4 receptor peptide with a KD of 300 nM....
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/1074-7613(95)90013-6
更新日期:1995-06-01 00:00:00
abstract::Diet-induced obesity can induce low-level inflammation and insulin resistance. Interleukin-1β (IL-1β) is one of the key proinflammatory cytokines that contributes to the generation of insulin resistance and diabetes, but the mechanisms that regulate obesity-driven inflammation are ill defined. Here we found reduced ex...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2014.11.013
更新日期:2014-12-18 00:00:00
abstract::Two waves of immunoglobulin gene rearrangements, first of the heavy, then of the light chain chain gene loci form functional immunoglobulin genes during B cell development. In mouse bone marrow the differential surface expression of B220 (CD45R), c-kit, CD25, and surrogate light chain as well as the cell cycle status ...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/1074-7613(95)90131-0
更新日期:1995-11-01 00:00:00
abstract::In this issue of Immunity, Xu et al. reveal that dermal dendritic cells produce interleukin-31, which acts on neurons to promote wound itch. Their findings link itch associated with deeper wounds-wounds that extend beyond the epithelium-to the cells and cytokines that mediate wound healing. ...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2020.07.016
更新日期:2020-08-18 00:00:00
abstract::The c-Myb transcription factor is crucial during definitive hematopoiesis. However, the embryonic lethality of Myb traditional null mutations has precluded analysis of c-Myb function in lymphocytes. Using tissue-specific inactivation at the Myb locus, we demonstrate that loss of Myb causes a partial block during B cel...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2005.08.005
更新日期:2005-09-01 00:00:00
abstract::The contribution of MyD88 adaptor-mediated signaling in immune responses to fungi is largely unexplored. In this issue of Immunity, show that MyD88 is dispensable in several aspects of dendritic-cell trafficking and T cell differentiation in response to a respiratory fungus. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2006.09.004
更新日期:2006-10-01 00:00:00
abstract::Kupffer cells (KCs) are liver-resident macrophages that self-renew by proliferation in the adult independently from monocytes. However, how they are maintained during non-alcoholic steatohepatitis (NASH) remains ill defined. We found that a fraction of KCs derived from Ly-6C+ monocytes during NASH, underlying impaired...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2020.06.003
更新日期:2020-09-15 00:00:00
abstract::Notch proteins are cell surface receptors that mediate developmental cell specification events. To explore the function of murine Notch1, an essential portion of the gene was flanked with loxP sites and inactivation induced via interferon-regulated Cre recombinase. Mice with a neonatally induced loss of Notch1 functio...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80054-0
更新日期:1999-05-01 00:00:00
abstract::B7-0 or B7-2 (CD86) is a T cell costimulatory molecule that binds the same receptors (CD28 and CTLA-4) as B7-1 (CD80), but shares with it only approximately 25% sequence identity and is expressed earlier during an immune response. Here we show that human CD86 maintains similar (within approximately 2- to 3-fold) overa...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(94)80021-9
更新日期:1994-12-01 00:00:00
abstract::The Toll-like receptor 3 (TLR3) and TLR4-signaling pathway that involves the adaptor protein TRIF activates type I interferon (IFN) and proinflammatory cytokine expression. Little is known about how TRIF pathway-dependent gene expression is regulated. SH2-containing protein tyrosine phosphatase 2 (SHP-2) is a widely e...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2006.10.014
更新日期:2006-12-01 00:00:00
abstract::Cytokine regulation of B cell development was analyzed using interleukin-2 (IL-2)-induced transcription of the J chain gene as a model system. A nuclear target of the IL-2 signal was identified as the Pax5 transcription factor, BSAP, which recognizes a negative regulatory motif in the J chain promoter. Functional assa...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80263-0
更新日期:1996-10-01 00:00:00
abstract::The tumor necrosis factor receptor superfamily member HVEM is one of the most frequently mutated surface proteins in germinal center (GC)-derived B cell lymphomas. We found that HVEM deficiency increased B cell competitiveness during pre-GC and GC responses. The immunoglobulin (Ig) superfamily protein BTLA regulated H...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2019.05.022
更新日期:2019-08-20 00:00:00
abstract::Metabolic engagement is intrinsic to immune cell function. Prostaglandin E2 (PGE2) has been shown to modulate macrophage activation, yet how PGE2 might affect metabolism is unclear. Here, we show that PGE2 caused mitochondrial membrane potential (Δψm) to dissipate in interleukin-4-activated (M(IL-4)) macrophages. Effe...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2018.10.011
更新日期:2018-12-18 00:00:00
abstract::NKG2D is an activating receptor on CD8(+) T cells and NK cells that has been implicated in immunity against tumors and microbial pathogens. Here we show that RAE-1 is present in prediabetic pancreas islets of NOD mice and that autoreactive CD8(+) T cells infiltrating the pancreas express NKG2D. Treatment with a nondep...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2004.05.008
更新日期:2004-06-01 00:00:00
abstract::Oxidative stress leads to impaired T cell activation. A central integrator of T cell activation is the actin-remodelling protein cofilin. Cofilin is activated through dephosphorylation at Ser3. Activated cofilin enables actin dynamics through severing and depolymerization of F-actin. Binding of cofilin to actin is req...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2008.06.016
更新日期:2008-09-19 00:00:00
abstract::The participation of a specific subset of B cells and how they are regulated in cancer is unclear. Here, we demonstrate that the proportion of CD5(+) relative to interleukin-6 receptor α (IL-6Rα)-expressing B cells was greatly increased in tumors. CD5(+) B cells responded to IL-6 in the absence of IL-6Rα. IL-6 directl...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2016.04.003
更新日期:2016-04-19 00:00:00
abstract::The immunological synapse is characterized by the reorganization of membrane proteins at the immunological synapse. Active cytoskeletal mechanisms are involved in recruiting the TCR, accessory molecules, and the integrin LFA-1 to the contact area. Other molecules like CD43 are excluded from the contact area, but the m...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/s1074-7613(01)00237-0
更新日期:2001-11-01 00:00:00
abstract::Virus-specific memory T cell populations demonstrate plasticity in antigenic and functional phenotype, in recognition of antigen, and in their ability to accommodate new memory T cell populations. The adaptability of complex antigen-specific T cell repertoires allows the host to respond to a diverse array of pathogens...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/s1074-7613(03)00356-x
更新日期:2004-01-01 00:00:00
abstract::Members of the extended interleukin-1 (IL-1) cytokine family, such as IL-1, IL-18, IL-33, and IL-36, play a pivotal role in the initiation and amplification of immune responses. However, deregulated production and/or activation of these cytokines can lead to the development of multiple inflammatory disorders. IL-1 fam...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2015.06.003
更新日期:2015-06-16 00:00:00