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Alternative activation of macrophages: mechanism and functions.

Abstract：

:The concept of an alternative pathway of macrophage activation has stimulated interest in its definition, mechanism, and functional significance in homeostasis and disease. We assess recent research in this field, argue for a restricted definition, and explore pathways by which the T helper 2 (Th2) cell cytokines interleukin-4 (IL-4) and IL-13 mediate their effects on macrophage cell biology, their biosynthesis, and responses to a normal and pathological microenvironment. The stage is now set to gain deeper insights into the role of alternatively activated macrophages in immunobiology.

journal_name

Immunity

journal_title

Immunity

authors

Gordon S,Martinez FO

doi

10.1016/j.immuni.2010.05.007

subject

Has Abstract

pub_date

2010-05-28 00:00:00

pages

593-604

issue

5

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(10)00173-1

journal_volume

32

pub_type

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