Abstract：
:Minor or histocompatibility (H) antigens are recognized by CD4+ and CD8+ T lymphocytes as short polymorphic peptides associated with MHC molecules. They are the targets of graft versus host and graft versus leukemia responses following bone marrow transplantation between HLA-identical siblings. Several genes encoding class I-restricted minor H epitopes have been identified, but approaches used for these have proved difficult to adapt for cloning class II-restricted minor H genes. We have combined the unique antigen-presenting properties of dendritic cells and high levels of episomal expression following transfection of COS cells to identify a Y chromosome gene encoding two HY peptide epitopes, HYAb and HYEk.
journal_name
Immunityjournal_title
Immunityauthors
Scott D,Addey C,Ellis P,James E,Mitchell MJ,Saut N,Jurcevic S,Simpson Edoi
10.1016/s1074-7613(00)80221-6keywords:
subject
Has Abstractpub_date
2000-06-01 00:00:00pages
711-20issue
6eissn
1074-7613issn
1097-4180pii
S1074-7613(00)80221-6journal_volume
12pub_type
杂志文章相关文献
IMMUNITY文献大全abstract：:Invariant chain (Ii)-negative mice exhibit defects in MHC class II assembly and transport that results in reduced levels of surface class II, altered antigen presentation, and inefficient positive selection of CD4+ T cells. Many CD4+ T cells that do mature in Ii-negative mice express a cell surface phenotype consisten...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/1074-7613(95)90120-5
更新日期：1995-09-01 00:00:00
abstract：:In this issue of Immunity, Xu et al. reveal that dermal dendritic cells produce interleukin-31, which acts on neurons to promote wound itch. Their findings link itch associated with deeper wounds-wounds that extend beyond the epithelium-to the cells and cytokines that mediate wound healing. ...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2020.07.016
更新日期：2020-08-18 00:00:00
abstract：:Dietary fiber protects against chronic inflammatory diseases by dampening immune responses through short-chain fatty acids (SCFAs). Here we examined the effect of dietary fiber in viral infection, where the anti-inflammatory properties of SCFAs in principle could prevent protective immunity. Instead, we found that fer...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2018.04.022
更新日期：2018-05-15 00:00:00
abstract：:Chimeric antigen receptors (CARs) redirect T cell cytotoxicity against cancer cells, providing a promising approach to cancer immunotherapy. Despite extensive clinical use, the attributes of CAR co-stimulatory domains that impact persistence and resistance to exhaustion of CAR-T cells remain largely undefined. Here, w...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2016.01.021
更新日期：2016-02-16 00:00:00
abstract：:The c-Myb transcription factor is crucial during definitive hematopoiesis. However, the embryonic lethality of Myb traditional null mutations has precluded analysis of c-Myb function in lymphocytes. Using tissue-specific inactivation at the Myb locus, we demonstrate that loss of Myb causes a partial block during B cel...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2005.08.005
更新日期：2005-09-01 00:00:00
abstract：:Antibodies play major roles in immunity to malaria; however, a limited understanding of mechanisms mediating protection is a major barrier to vaccine development. We have demonstrated that acquired human anti-malarial antibodies promote complement deposition on the merozoite to mediate inhibition of erythrocyte invasi...
journal_title：Immunity
pub_type： 临床试验,杂志文章
doi：10.1016/j.immuni.2015.02.012
更新日期：2015-03-17 00:00:00
abstract：:In this issue of Immunity, Campbell et al. (2014) demonstrate that hypoxia caused by the respiratory burst of infiltrating neutrophils activates hypoxia inducible factor (HIF) in epithelial cells and protects the mucosa cells in an experimental model of inflammatory bowel disease. ...
journal_title：Immunity
pub_type： 评论,杂志文章
doi：10.1016/j.immuni.2013.12.003
更新日期：2014-01-16 00:00:00
abstract：:Autophagy constitutes a mechanism for the sequestration and lysosomal degradation of various cytoplasmic structures, including damaged organelles and invading microorganisms. Autophagy not only represents an essential cell-intrinsic mechanism to protect against internal and external stress conditions but also shapes c...
journal_title：Immunity
pub_type： 杂志文章,评审
doi：10.1016/j.immuni.2013.07.017
更新日期：2013-08-22 00:00:00
abstract：:Fas receptor-induced apoptosis plays critical roles in immune homeostasis. However, most of the signal transduction events distal to Fas ligation have not been elucidated. Here, we show that Ras is activated following ligation of Fas on lymphoid lines. The activation of Ras is a critical component of this apoptotic pa...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/1074-7613(95)90142-6
更新日期：1995-04-01 00:00:00
abstract：:Appropriate priming of tolerogenic or effector immune responses is crucial for intestinal homeostasis. Recently in Nature, Esterházy et al. (2019) reveal how compartmentalization of lymphatic drainage to functionally distinct lymph nodes facilitates the simultaneous induction of tolerogenic and effector responses. ...
journal_title：Immunity
pub_type： 评论,杂志文章
doi：10.1016/j.immuni.2019.06.018
更新日期：2019-07-16 00:00:00
abstract：:Indoleamine 2,3 dioxygenase (IDO) catabolizes the amino acid tryptophan. IDO-expressing immunoregulatory dendritic cells (DCs) have been implicated in settings including tumors, autoimmunity, and transplant tolerance. However, the downstream molecular mechanisms by which IDO functions to regulate T cell responses rema...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2005.03.013
更新日期：2005-05-01 00:00:00
abstract：:Follicular helper T (Tfh) cells are specialized providers of T cell help to B cells, and are essential for germinal center formation, affinity maturation, and the development of most high-affinity antibodies and memory B cells. Tfh cell differentiation is a multistage, multifactorial process involving B cell lymphoma ...
journal_title：Immunity
pub_type： 杂志文章,评审
doi：10.1016/j.immuni.2014.10.004
更新日期：2014-10-16 00:00:00
abstract：:Following the fate of antigen-specific memory B cells has been difficult. In this issue of Immunity, Krishnamurty et al. (2016) use a novel B cell tetramer to define Plasmodium-specific memory B cells in parasite-infected mice and demonstrate that after re-infection, somatically mutated IgM(+) memory B cells function ...
journal_title：Immunity
pub_type： 评论,杂志文章
doi：10.1016/j.immuni.2016.08.005
更新日期：2016-08-16 00:00:00
abstract：:Description of macrophage activation is currently contentious and confusing. Like the biblical Tower of Babel, macrophage activation encompasses a panoply of descriptors used in different ways. The lack of consensus on how to define macrophage activation in experiments in vitro and in vivo impedes progress in multiple...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2014.06.008
更新日期：2014-07-17 00:00:00
abstract：:Among 631 substitutions present in 90 nurse shark immunoglobulin light chain somatic mutants, 338 constitute 2-4 bp stretches of adjacent changes. An absence of mutations in perinatal sequences and the bias for one mutating V gene in adults suggest that the diversification is antigen dependent. The substitutions share...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/s1074-7613(02)00300-x
更新日期：2002-04-01 00:00:00
abstract：:Intraepithelial T lymphocytes possess a (TGF beta)-inducible integrin complex that consists of the beta 7 integrin chain in association with a novel alpha chain, murine alpha M290. Using antibodies directed against the murine alpha M290 chain, IL-3-dependent murine bone marrow-derived mast cells demonstrated positive ...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/1074-7613(94)90070-1
更新日期：1994-08-01 00:00:00
abstract：:Virus-specific memory T cell populations demonstrate plasticity in antigenic and functional phenotype, in recognition of antigen, and in their ability to accommodate new memory T cell populations. The adaptability of complex antigen-specific T cell repertoires allows the host to respond to a diverse array of pathogens...
journal_title：Immunity
pub_type： 杂志文章,评审
doi：10.1016/s1074-7613(03)00356-x
更新日期：2004-01-01 00:00:00
abstract：:Mouse blood monocytes include two main subsets usually discriminated by the expression of the Ly6C surface marker. The study by Mildner et al. (2017) in this issue of Immunity clarifies the transcriptional circuits controlling the generation of Ly6C- cells from their obligate precursors, the Ly6C+ monocytes. ...
journal_title：Immunity
pub_type： 评论,杂志文章
doi：10.1016/j.immuni.2017.04.010
更新日期：2017-05-16 00:00:00
abstract：:The β common chain cytokines GM-CSF, IL-3, and IL-5 regulate varied inflammatory responses that promote the rapid clearance of pathogens but also contribute to pathology in chronic inflammation. Therapeutic interventions manipulating these cytokines are approved for use in some cancers as well as allergic and autoimmu...
journal_title：Immunity
pub_type： 杂志文章,评审
doi：10.1016/j.immuni.2019.03.022
更新日期：2019-04-16 00:00:00
abstract：:For a preferential homing of T cells to the gut, expression of the integrin alpha4beta7 and the chemokine receptor CCR9 is essential and is induced by antigenic stimulation with dendritic cells from the gut-associated lymphoid organs. Here, we show that the vitamin A (retinol) metabolite, retinoic acid, enhances the e...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2004.08.011
更新日期：2004-10-01 00:00:00
abstract：:Recruitment of immune cells with antimicrobial activities is essential to fight local infections but has the potential to trigger immunopathology. Whether the immune system has the ability to sense inflammation intensity and self-adjust accordingly to limit tissue damage remains to be fully established. During local i...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2018.07.014
更新日期：2018-10-16 00:00:00
abstract：:CD4+ T cells orchestrate immune responses and destruction of allogeneic organ transplants, but how this process is regulated on a transcriptional level remains unclear. Here, we demonstrated that interferon regulatory factor 4 (IRF4) was a key transcriptional determinant controlling T cell responses during transplanta...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2017.11.003
更新日期：2017-12-19 00:00:00
abstract：:Notch signaling has been identified as an important regulator of leukocyte differentiation and thymic maturation. Less is known about the role of Notch signaling in regulating mature T cells. We examined the role of Notch 1 in regulating peripheral T cell activity in vitro and in vivo. Coligation of Notch 1 together w...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/s1074-7613(04)00081-0
更新日期：2004-04-01 00:00:00
abstract：:How antigen valency affects B cells in vivo during immune responses is not well understood. Here, using HIV immunogens with defined valencies ranging from 1 to 60, we investigated the role of antigen valency during different phases of B cell responses in vivo. Highly multimerized immunogens preferentially rapidly acti...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2020.08.001
更新日期：2020-09-15 00:00:00
abstract：:Recognition of major histocompatibility class I molecules on target cells by natural killer (NK) cells confers selective protection from NK-mediated lysis. Cross-linking of the p58 NK receptor, involved in the recognition of HLA-C alleles, delivers a negative signal that prevents target cell lysis. Molecular cloning o...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/1074-7613(95)90025-x
更新日期：1995-05-01 00:00:00
abstract：:CD4(+) T cells deficient in signaling lymphocyte activation molecule (SLAM)-associated protein (SAP) exhibit a selective impairment in adhesion to antigen-presenting B cells but not dendritic cells (DCs), resulting in defective germinal center formation. However, the nature of this selective adhesion defect remained u...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2010.01.010
更新日期：2010-02-26 00:00:00
abstract：:Elevated inflammation in the female genital tract is associated with increased HIV risk. Cervicovaginal bacteria modulate genital inflammation; however, their role in HIV susceptibility has not been elucidated. In a prospective cohort of young, healthy South African women, we found that individuals with diverse genita...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2016.12.013
更新日期：2017-01-17 00:00:00
abstract：:The innate immune system comprises several classes of pattern recognition receptors, including Toll-like receptors (TLRs), NOD-like receptors (NLRs), and RIG-1-like receptors (RLRs). TLRs recognize microbes on the cell surface and in endosomes, whereas NLRs and RLRs detect microbial components in the cytosol. Here we ...
journal_title：Immunity
pub_type： 杂志文章,评审
doi：10.1016/j.immuni.2007.10.002
更新日期：2007-10-01 00:00:00
abstract：:PCR analyses of the kappaL chain locus in single B-lineage cells of wild-type, Ckappa-, or JCkappa-deficient homozygous or heterozygous mice often detect multiple in- and out-of-frame rearrangements at the kappaL and lambdaL loci. They are most frequent in small pre-BII cells and equally so in wild-type and kappaL cha...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/s1074-7613(00)80107-7
更新日期：1999-09-01 00:00:00
abstract：:The transcription factor Blimp-1 regulates the overall accumulation of virus-specific CD8⁺ T cells during acute viral infections. We found that increased proliferation and survival of Blimp-1-deficient CD8⁺ T cells resulted from sustained expression of CD25 and CD27 and persistent cytokine responsiveness. Silencing of...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2013.08.032
更新日期：2013-10-17 00:00:00
