Abstract:
:Mouse NK cells express at least seven inhibitory Ly49 receptors. Here we employ a semiquantitative cell-cell adhesion assay as well as class I/peptide tetramers to provide a comprehensive analysis of specificities of Ly49 receptors for class I MHC molecules in eight MHC haplotypes. Different Ly49 receptors exhibited diverse binding properties. The degree of class I binding was related to the extent of functional inhibition. The tetramer studies demonstrated that neither glycosylation nor coreceptors were necessary for class I binding to Ly49 receptors and uncovered peptide-specific recognition by a Ly49 receptor. The results provide a foundation for interpreting and integrating many existing functional studies as well as for designing tests of NK cell development and self-tolerance.
journal_name
Immunityjournal_title
Immunityauthors
Hanke T,Takizawa H,McMahon CW,Busch DH,Pamer EG,Miller JD,Altman JD,Liu Y,Cado D,Lemonnier FA,Bjorkman PJ,Raulet DHdoi
10.1016/s1074-7613(00)80082-5keywords:
subject
Has Abstractpub_date
1999-07-01 00:00:00pages
67-77issue
1eissn
1074-7613issn
1097-4180pii
S1074-7613(00)80082-5journal_volume
11pub_type
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