当前位置： SCI文献检索 > IMMUNITY期刊下所有文献 > HIV-1-induced thymocyte depletion is associated with indirect cytopathogenicity and infection of progenitor cells in vivo.

HIV-1-induced thymocyte depletion is associated with indirect cytopathogenicity and infection of progenitor cells in vivo.

Abstract：

:Direct and indirect cytopathic mechanisms have been proposed to account for the loss of CD4+ T cells after infection with human immunodeficiency virus type 1 (HIV-1). We report here that HIV-1 infection of the human thymus in vivo results in thymocyte depletion by at least two different mechanisms. Thymocytes within multiple stages of differentiation are induced to die of apoptosis; most of these cells are uninfected. Additionally, thymopoiesis is interrupted by direct infection and destruction of intrathymic CD3-CD4+CD8- progenitor cells. These mechanisms are differentially induced by distinct isolates of HIV-1.

journal_name

Immunity

journal_title

Immunity

authors

Su L,Kaneshima H,Bonyhadi M,Salimi S,Kraft D,Rabin L,McCune JM

doi

10.1016/1074-7613(95)90076-4

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

25-36

issue

1

eissn

1074-7613

issn

1097-4180

pii

1074-7613(95)90076-4

journal_volume

2

pub_type

杂志文章

相关文献

IMMUNITY文献大全
  • Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signals.

    abstract：:Inflammation can activate self-reactive CD8(+) T cells and induce autoimmunity. Here we show in a CD8(+) T cell-mediated model of type 1 diabetes that CD4(+)CD25(+) Treg cells prevent beta cell destruction following localized inflammation in the islets of Langerhans. These Treg cells accumulate preferentially in the p...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(02)00279-0

    authors： Green EA,Choi Y,Flavell RA

    更新日期：2002-02-01 00:00:00

  • ReaDAPting the Role of PGRP-SD in Bacterial Sensing and Immune Activation.

    abstract：:Contradictory to previous reports, Iatsenko et al. (2016) reveal that PGRP-SD regulates the Imd signaling pathway rather than the Toll pathway in Drosophila and shed light on a decade-old mystery of conflicting structural and phenotypic data. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2016.11.002

    authors： Monahan A,Kleino A,Silverman N

    更新日期：2016-11-15 00:00:00

  • The chemokine receptor CXCR6 controls the functional topography of interleukin-22 producing intestinal innate lymphoid cells.

    abstract：:Interleukin-22 (IL-22) plays a critical role in mucosal defense, although the molecular mechanisms that ensure IL-22 tissue distribution remain poorly understood. We show that the CXCL16-CXCR6 chemokine-chemokine receptor axis regulated group 3 innate lymphoid cell (ILC3) diversity and function. CXCL16 was constitutiv...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2014.10.007

    authors： Satoh-Takayama N,Serafini N,Verrier T,Rekiki A,Renauld JC,Frankel G,Di Santo JP

    更新日期：2014-11-20 00:00:00

  • Non-canonical NF-κB Antagonizes STING Sensor-Mediated DNA Sensing in Radiotherapy.

    abstract：:The NF-κB pathway plays a crucial role in supporting tumor initiation, progression, and radioresistance of tumor cells. However, the role of the NF-κB pathway in radiation-induced anti-tumor host immunity remains unclear. Here we demonstrated that inhibiting the canonical NF-κB pathway dampened the therapeutic effect ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2018.07.008

    authors： Hou Y,Liang H,Rao E,Zheng W,Huang X,Deng L,Zhang Y,Yu X,Xu M,Mauceri H,Arina A,Weichselbaum RR,Fu YX

    更新日期：2018-09-18 00:00:00

  • Foxp3 and natural regulatory T cells: key to a cell lineage?

    abstract：:The recent characterization of a mutant strain of mice generated five decades ago in a program to study ionizing radiation in mammals (and, ironically, derived from a nonmutagenized control animal) is helping to dissect a now resurgent area of immunology. Despite a vast literature during the 1970s, the study of suppre...

    journal_title：Immunity

    pub_type： 杂志文章,评审

    doi：10.1016/s1074-7613(03)00207-3

    authors： Ramsdell F

    更新日期：2003-08-01 00:00:00

  • Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to Prostaglandin E2.

    abstract：:Metabolic engagement is intrinsic to immune cell function. Prostaglandin E2 (PGE2) has been shown to modulate macrophage activation, yet how PGE2 might affect metabolism is unclear. Here, we show that PGE2 caused mitochondrial membrane potential (Δψm) to dissipate in interleukin-4-activated (M(IL-4)) macrophages. Effe...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2018.10.011

    authors： Sanin DE,Matsushita M,Klein Geltink RI,Grzes KM,van Teijlingen Bakker N,Corrado M,Kabat AM,Buck MD,Qiu J,Lawless SJ,Cameron AM,Villa M,Baixauli F,Patterson AE,Hässler F,Curtis JD,O'Neill CM,O'Sullivan D,Wu D,Mittler

    更新日期：2018-12-18 00:00:00

  • Monocyte subsets responsible for immunoglobulin G-dependent effector functions in vivo.

    abstract：:Immunoglobulin G (IgG) antibodies confer protection against pathogenic microorganisms, serve as therapeutics in tumor therapy, and are involved in destruction of healthy tissues during autoimmune diseases. Understanding the molecular pathways and effector cell types involved in antibody-mediated effector functions is ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2011.11.009

    authors： Biburger M,Aschermann S,Schwab I,Lux A,Albert H,Danzer H,Woigk M,Dudziak D,Nimmerjahn F

    更新日期：2011-12-23 00:00:00

  • Systems Medicine in Chronic Inflammatory Diseases.

    abstract：:Chronic inflammatory diseases represent an increasing medical burden, yet neither tools to predict the individual disease course nor causal cures are at hand. We discuss opportunities for systems medicine to derive precise, individualized disease models and outline the European consortium SYSCID as part of the roadmap...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2018.03.022

    authors： Schultze JL,SYSCID consortium.,Rosenstiel P

    更新日期：2018-04-17 00:00:00

  • Noncanonical autophagy is required for type I interferon secretion in response to DNA-immune complexes.

    abstract：:Toll-like receptor-9 (TLR9) is largely responsible for discriminating self from pathogenic DNA. However, association of host DNA with autoantibodies activates TLR9, inducing the pathogenic secretion of type I interferons (IFNs) from plasmacytoid dendritic cells (pDCs). Here, we found that in response to DNA-containing...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2012.09.014

    authors： Henault J,Martinez J,Riggs JM,Tian J,Mehta P,Clarke L,Sasai M,Latz E,Brinkmann MM,Iwasaki A,Coyle AJ,Kolbeck R,Green DR,Sanjuan MA

    更新日期：2012-12-14 00:00:00

  • Immunoglobulin heavy chain gene replacement: a mechanism of receptor editing.

    abstract：:We have generated a site-directed transgenic (sd-tg) mouse model in which the JH locus has been replaced with a rearranged VDJ coding for the heavy chain of an anti-DNA antibody. In these mice, B cells expressing the anti-dsDNA specificity are negatively regulated. We observe a novel mechanism for B cell tolerance, re...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/1074-7613(95)90064-0

    authors： Chen C,Nagy Z,Prak EL,Weigert M

    更新日期：1995-12-01 00:00:00

  • Down-regulation of IL-4 gene transcription and control of Th2 cell differentiation by a mechanism involving NFAT1.

    abstract：:Transcription factors of the NFAT family play a critical role in the immune response by activating the expression of cytokines and other inducible genes in antigen-stimulated cells. Here we show that a member of this family, NFAT1, is involved in down-regulating the late phase of IL-4 gene transcription, thus inhibiti...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80403-3

    authors： Kiani A,Viola JP,Lichtman AH,Rao A

    更新日期：1997-12-01 00:00:00

  • Monocyte-Derived Macrophages: The Missing Link in Organ Transplantation.

    abstract：:Successful organ transplantation requires an optimal innate immune response to avoid tissue injury. In this issue of Immunity, Braza et al. (2018) inhibit pro-inflammatory activation of infiltrating graft macrophages using nanotechnology tools to promote immune tolerance, leading to long-term transplant acceptance in ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2018.11.005

    authors： Pascual-Gil S,Epelman S

    更新日期：2018-11-20 00:00:00

  • Immunological tolerance to a pancreatic antigen as a result of local expression of TNFalpha by islet beta cells.

    abstract：:Recent experiments have suggested that tumor necrosis factor alpha (TNFalpha) can down-regulate islet-specific T cells and prevent the development of autoimmune diabetes. Here we demonstrate that transgenic mice expressing both TNFalpha and the Leishmania major LACK antigen in the pancreas (RIP-TNFalpha/RIP-LACK) exhi...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80361-1

    authors： McSorley SJ,Soldera S,Malherbe L,Carnaud C,Locksley RM,Flavell RA,Glaichenhaus N

    更新日期：1997-09-01 00:00:00

  • Silence of the ROS.

    abstract：:Reactive oxygen species (ROS) are generated during T cell activation and serve a signaling function but can also be damaging. In this issue of Immunity, Zhang et al. (2016) show that miR-23a prevents ROS-elicited necrosis by suppressing cyclophilin D (PPIF), a regulator of ROS escape from mitochondria. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2016.02.027

    authors： Agudo J,Brown BD

    更新日期：2016-03-15 00:00:00

  • Boosting Apoptotic Cell Clearance by Colonic Epithelial Cells Attenuates Inflammation In Vivo.

    abstract：:Few apoptotic corpses are seen even in tissues with high cellular turnover, leading to the notion that the capacity for engulfment in vivo is vast. Whether corpse clearance can be enhanced in vivo for potential benefit is not known. In a colonic inflammation model, we noted that the expression of the phagocytic recept...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2016.02.005

    authors： Lee CS,Penberthy KK,Wheeler KM,Juncadella IJ,Vandenabeele P,Lysiak JJ,Ravichandran KS

    更新日期：2016-04-19 00:00:00

  • Human tyk2 kinase deficiency: another primary immunodeficiency syndrome.

    abstract：:Janus kinases are critical for cytokine signaling. Mutations of Jak3 cause primary immunodeficiency, but Minegishi et al. (2006) now show that mutation of another Jak, tyrosine kinase 2, underlies another human immunodeficiency syndrome. ...

    journal_title：Immunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.immuni.2006.10.007

    authors： Watford WT,O'Shea JJ

    更新日期：2006-11-01 00:00:00

  • Whole-body anatomy of human T cells.

    abstract：:Knowledge of the regional tissue distribution of T cell subsets is a prerequisite for understanding protective immunity and the pathophysiology of T cell-mediated diseases. In this issue of Immunity, Sathaliyawala et al. (2012) present a comprehensive human tissue T cell analysis. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2013.01.006

    authors： Neuenhahn M,Busch DH

    更新日期：2013-01-24 00:00:00

  • Inflammasome Activation Triggers Caspase-1-Mediated Cleavage of cGAS to Regulate Responses to DNA Virus Infection.

    abstract：:Viral infection triggers host innate immune responses that result in the production of various cytokines including type I interferons (IFN), activation of inflammasomes, and programmed cell death of the infected cells. Tight control of inflammatory cytokine production is crucial for the triggering of an effective immu...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2017.02.011

    authors： Wang Y,Ning X,Gao P,Wu S,Sha M,Lv M,Zhou X,Gao J,Fang R,Meng G,Su X,Jiang Z

    更新日期：2017-03-21 00:00:00

  • Group 3 innate lymphoid cells inhibit T-cell-mediated intestinal inflammation through aryl hydrocarbon receptor signaling and regulation of microflora.

    abstract：:Aryl hydrocarbon receptor (Ahr) is crucial for the maintenance and function of group 3 innate lymphoid cells (ILCs), which are important in gut immunity. Because Ahr promotes T helper 17 (Th17) cell differentiation in vitro, it is reasonable to expect that Ahr would enhance Th17 cells in vivo. Instead, we show that Ah...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2013.08.002

    authors： Qiu J,Guo X,Chen ZM,He L,Sonnenberg GF,Artis D,Fu YX,Zhou L

    更新日期：2013-08-22 00:00:00

  • Feeling a little SYK after mixing BAFF with BCR.

    abstract：:In this issue of Immunity, Schweighoffer et al. (2013) report that full BAFF responsiveness in B cells requires the tyrosine kinase Syk and that BAFF may co-opt components of the B cell receptor in transmitting its survival signal. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2013.03.001

    authors： Infantino S,Tarlinton DM

    更新日期：2013-03-21 00:00:00

  • Stat5 activation plays a critical role in Th2 differentiation.

    abstract：:Upon TCR engagement, naive CD4 T cells differentiate toward the Th1 or Th2 phenotype. IL-4, acting through Stat6, plays a major role in Th2 differentiation; IL-2 has also been reported to be essential. Here, we report that retroviral (RV)-mediated expression of a constitutively active Stat5A mutant (STAT5A1*6) can ful...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(03)00292-9

    authors： Zhu J,Cote-Sierra J,Guo L,Paul WE

    更新日期：2003-11-01 00:00:00

  • Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology.

    abstract：:Macrophage/neutrophil-specific IL-4 receptor alpha-deficient mice (LysM(Cre)IL-4Ralpha(-/flox)) were generated to understand the role of IL-4/IL-13 responsive myeloid cells during Type 2 immune responses. LysM(Cre)IL-4Ralpha(-/flox) mice developed protective immunity against Nippostrongylus brasiliensis accompanied by...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(04)00107-4

    authors： Herbert DR,Hölscher C,Mohrs M,Arendse B,Schwegmann A,Radwanska M,Leeto M,Kirsch R,Hall P,Mossmann H,Claussen B,Förster I,Brombacher F

    更新日期：2004-05-01 00:00:00

  • Defining Genetic Variation in Widely Used Congenic and Backcrossed Mouse Models Reveals Varied Regulation of Genes Important for Immune Responses.

    abstract：:Genetic variation influences how the genome is interpreted in individuals and in mouse strains used to model immune responses. We developed approaches to utilize next-generation sequencing datasets to identify sequence variation in genes and enhancer elements in congenic and backcross mouse models. We defined genetic ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2019.05.006

    authors： Chisolm DA,Cheng W,Colburn SA,Silva-Sanchez A,Meza-Perez S,Randall TD,Weinmann AS

    更新日期：2019-07-16 00:00:00

  • Is EBV persistence in vivo a model for B cell homeostasis?

    abstract：:We have measured the absolute numbers of EBV-infected B cells in the peripheral blood of healthy persistently infected individuals. Single measurements on a panel of 15 healthy individuals demonstrate that the frequency varies over a wide range from 1-50 per 10(6) B cells. Repeat measurements over 1-3.5 years on sever...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80493-8

    authors： Khan G,Miyashita EM,Yang B,Babcock GJ,Thorley-Lawson DA

    更新日期：1996-08-01 00:00:00

  • Innate-like Cytotoxic Function of Bystander-Activated CD8+ T Cells Is Associated with Liver Injury in Acute Hepatitis A.

    abstract：:Acute hepatitis A (AHA) involves severe CD8+ T cell-mediated liver injury. Here we showed during AHA, CD8+ T cells specific to unrelated viruses became activated. Hepatitis A virus (HAV)-infected cells produced IL-15 that induced T cell receptor (TCR)-independent activation of memory CD8+ T cells. TCR-independent acti...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2017.11.025

    authors： Kim J,Chang DY,Lee HW,Lee H,Kim JH,Sung PS,Kim KH,Hong SH,Kang W,Lee J,Shin SY,Yu HT,You S,Choi YS,Oh I,Lee DH,Lee DH,Jung MK,Suh KS,Hwang S,Kim W,Park SH,Kim HJ,Shin EC

    更新日期：2018-01-16 00:00:00

  • Small but Mighty: Selected Commensal Bacterial Species Determine the Effectiveness of Anti-cancer Immunotherapies.

    abstract：:Commensal microorganisms influence malignant progression by altering systemic inflammation. New data from two groups (Vétizou et al., 2015; Sivan et al., 2015) indicate that the abundance of specific commensal bacterial species enhances the anti-cancer activity of immune checkpoint inhibitors. ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2015.11.014

    authors： Conejo-Garcia JR,Rutkowski MR

    更新日期：2015-12-15 00:00:00

  • Genome-wide Screens Identify Lineage- and Tumor-Specific Genes Modulating MHC-I- and MHC-II-Restricted Immunosurveillance of Human Lymphomas.

    abstract：:Tumors frequently subvert major histocompatibility complex class I (MHC-I) peptide presentation to evade CD8+ T cell immunosurveillance, though how this is accomplished is not always well defined. To identify the global regulatory networks controlling antigen presentation, we employed genome-wide screening in human di...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2020.11.002

    authors： Dersh D,Phelan JD,Gumina ME,Wang B,Arbuckle JH,Holly J,Kishton RJ,Markowitz TE,Seedhom MO,Fridlyand N,Wright GW,Huang DW,Ceribelli M,Thomas CJ,Lack JB,Restifo NP,Kristie TM,Staudt LM,Yewdell JW

    更新日期：2021-01-12 00:00:00

  • We Can Still Be Friends: IFN-γ Breaks Up Macrophage Enhancers.

    abstract：:Interferon (IFN)-γ can prime macrophages for inflammatory responses by several mechanisms, including enhancer establishment and gene activation. In this issue of Immunity, Kang et al. (2017) provide insight into the mechanisms of IFN-γ-mediated gene repression as they show that IFN-γ promotes the disassembly of select...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2017.08.002

    authors： Novakovic B,Wang C,Logie C

    更新日期：2017-08-15 00:00:00

  • Monocytes Take Their Own Path to IL-1β.

    abstract：:Generally, two signals are required to activate the NLRP3 inflammasome. In this issue of Immunity, Hornung and colleagues (2016) describe an alternative inflammasome activation pathway in human monocytes triggering activation of the NLRP3 inflammasome in response to a single stimulus. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2016.03.015

    authors： Elliott EI,Sutterwala FS

    更新日期：2016-04-19 00:00:00

  • C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaB.

    abstract：:Adaptive immune responses by dendritic cells (DCs) are critically controlled by Toll-like receptor (TLR) function. Little is known about modulation of TLR-specific signaling by other pathogen receptors. Here, we have identified a molecular signaling pathway induced by the C-type lectin DC-SIGN that modulates TLR signa...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2007.03.012

    authors： Gringhuis SI,den Dunnen J,Litjens M,van Het Hof B,van Kooyk Y,Geijtenbeek TB

    更新日期：2007-05-01 00:00:00