ReaDAPting the Role of PGRP-SD in Bacterial Sensing and Immune Activation.

abstract：:Null mutations that cripple T cell receptor (TCR) signaling explain rare primary immunodeficiencies, but it is not understood why more common polymorphisms that lead to subtle TCR signaling defects are paradoxically associated with autoimmunity. Here we analyzed how a series of Zap70 variants with step-wise decreases ...

journal_title：Immunity

authors： Siggs OM,Miosge LA,Yates AL,Kucharska EM,Sheahan D,Brdicka T,Weiss A,Liston A,Goodnow CC

更新日期：2007-12-01 00:00:00

abstract：:The humoral immune response to protein antigens is composed of a rapid low-affinity IgM antibody response followed by an IgG response exhibiting higher affinity. Here, we demonstrate that Lsc, a protein that regulates G protein-coupled-receptor signaling and RhoA activation, is required by B lymphocytes for the antige...

journal_title：Immunity

authors： Rubtsov A,Strauch P,Digiacomo A,Hu J,Pelanda R,Torres RM

更新日期：2005-11-01 00:00:00

abstract：:Promising vaccines and results from recent clinical trials of therapeutic antibodies against Ebola virus offer hope for an end to this devastating disease. We asked three investigators in the field to share their views on the remaining challenges and important future research directions as we work toward controlling E...

journal_title：Immunity

authors：

更新日期：2019-12-17 00:00:00

abstract：:Effector T cells are critical for clearance of pathogens from sites of infection. Like cytotoxic CD8(+) T cells, CD4(+) helper T cells have been shown to deliver effector molecules directionally toward the immunological synapse, suggesting that infected cells need to be engaged individually to receive effector signals...

journal_title：Immunity

authors： Müller AJ,Filipe-Santos O,Eberl G,Aebischer T,Späth GF,Bousso P

更新日期：2012-07-27 00:00:00

abstract：:We have measured the absolute numbers of EBV-infected B cells in the peripheral blood of healthy persistently infected individuals. Single measurements on a panel of 15 healthy individuals demonstrate that the frequency varies over a wide range from 1-50 per 10(6) B cells. Repeat measurements over 1-3.5 years on sever...

journal_title：Immunity

authors： Khan G,Miyashita EM,Yang B,Babcock GJ,Thorley-Lawson DA

更新日期：1996-08-01 00:00:00

abstract：:Membrane recruitment of SHIP is responsible for the inhibitory signal generated by FcgammaRIIB coligation to the BCR. By reducing the level of PIP3, SHIP regulates the association of the tyrosine kinase Btk with the membrane through PH domain-phosphoinositol lipid interactions. Inhibition of BCR signaling by either Fc...

journal_title：Immunity

authors： Bolland S,Pearse RN,Kurosaki T,Ravetch JV

更新日期：1998-04-01 00:00:00

abstract：:CD8 T cells persist at high frequencies in peripheral organs after resolution of an immune response, and their presence in the periphery is important for resistance to secondary challenge. We show here that LCMV-specific T cells in peripheral tissue (peritoneal cavity, lung, fat pads) reacted much less with the apopto...

journal_title：Immunity

authors： Wang XZ,Stepp SE,Brehm MA,Chen HD,Selin LK,Welsh RM

更新日期：2003-05-01 00:00:00

abstract：:The Toll-like receptor 3 (TLR3) and TLR4-signaling pathway that involves the adaptor protein TRIF activates type I interferon (IFN) and proinflammatory cytokine expression. Little is known about how TRIF pathway-dependent gene expression is regulated. SH2-containing protein tyrosine phosphatase 2 (SHP-2) is a widely e...

journal_title：Immunity

authors： An H,Zhao W,Hou J,Zhang Y,Xie Y,Zheng Y,Xu H,Qian C,Zhou J,Yu Y,Liu S,Feng G,Cao X

更新日期：2006-12-01 00:00:00

abstract：:Transcriptional regulation of the Nos2 gene encoding inducible nitric oxide synthase (iNOS) requires type I interferon (IFN-I) signaling and additional signals emanating from pattern recognition receptors. Here we showed sequential and cooperative contributions of the transcription factors ISGF3 (a complex containing ...

journal_title：Immunity

authors： Farlik M,Reutterer B,Schindler C,Greten F,Vogl C,Müller M,Decker T

更新日期：2010-07-23 00:00:00

abstract：:Ikaros family members play an important role in hematopoietic development. Thompson et al. (2007) show that pre-BCR signaling induces Aiolos expression, which in turn suppresses the expression of the pre-BCR component lambda5 and eliminates the very structure that signaled its appearance. ...

journal_title：Immunity

authors： Kioussis D

更新日期：2007-03-01 00:00:00

abstract：:To define the role of TRAF proteins in CD40-dependent isotype switching in B cells, we introduced wild-type (WT) and mutant CD40 transgenes that lacked the binding motifs for TRAF6 (CD40deltaTRAF6), TRAF2 and TRAF3 (CD40deltaTRAF2/3), or both (CD40deltaTRAFs) into B cells of CD40(-/-) mice. The in vivo isotype switch ...

journal_title：Immunity

authors： Jabara H,Laouini D,Tsitsikov E,Mizoguchi E,Bhan A,Castigli E,Dedeoglu F,Pivniouk V,Brodeur S,Geha R

更新日期：2002-09-01 00:00:00

abstract：:It is unclear how an effective T cell repertoire is built from a limited array of T cell receptor (TCR) genes. In this issue of Immunity, Stadinski et al. (2011) demonstrate that TCR variable (V) α chains can indirectly affect Vβ-mediated recognition of the major histocompatibility complex (MHC) molecule. ...

journal_title：Immunity

authors： Turner SJ,Rossjohn J

更新日期：2011-11-23 00:00:00

abstract：:Distinct metabolic programs support the differentiation of CD4(+) T cells into separate functional subsets. In this study, we investigated metabolic mechanisms underlying the differentiation of IL-9-producing CD4(+) T cells (Th9) in allergic airway inflammation and cancerous tumors. We found that histone deacetylase S...

journal_title：Immunity

authors： Wang Y,Bi Y,Chen X,Li C,Li Y,Zhang Z,Wang J,Lu Y,Yu Q,Su H,Yang H,Liu G

更新日期：2016-06-21 00:00:00

abstract：:Following the fate of antigen-specific memory B cells has been difficult. In this issue of Immunity, Krishnamurty et al. (2016) use a novel B cell tetramer to define Plasmodium-specific memory B cells in parasite-infected mice and demonstrate that after re-infection, somatically mutated IgM(+) memory B cells function ...

journal_title：Immunity

authors： Stone SL,Lund FE

更新日期：2016-08-16 00:00:00

abstract：:How antigen valency affects B cells in vivo during immune responses is not well understood. Here, using HIV immunogens with defined valencies ranging from 1 to 60, we investigated the role of antigen valency during different phases of B cell responses in vivo. Highly multimerized immunogens preferentially rapidly acti...

journal_title：Immunity

authors： Kato Y,Abbott RK,Freeman BL,Haupt S,Groschel B,Silva M,Menis S,Irvine DJ,Schief WR,Crotty S

更新日期：2020-09-15 00:00:00

abstract：:In this issue of Immunity, Curotto de Lafaille et al. (2008) show that adaptive T regulatory cells control airway inflammation and that it is when they are generated that determines whether they function during acute or chronic inflammation. ...

journal_title：Immunity

authors： Ziegler SF

更新日期：2008-07-18 00:00:00

abstract：:Lipopolysaccharide binding protein (LBP) has a well-established role in LPS-induced immune responses. Here, we report that LBP also plays an essential role in the innate immune response to Gram-positive pneumococci, specifically to their major inflammatory component, pneumococcal cell wall (PCW). LBP was present in th...

journal_title：Immunity

authors： Weber JR,Freyer D,Alexander C,Schröder NW,Reiss A,Küster C,Pfeil D,Tuomanen EI,Schumann RR

更新日期：2003-08-01 00:00:00

abstract：:Two waves of immunoglobulin gene rearrangements, first of the heavy, then of the light chain chain gene loci form functional immunoglobulin genes during B cell development. In mouse bone marrow the differential surface expression of B220 (CD45R), c-kit, CD25, and surrogate light chain as well as the cell cycle status ...

journal_title：Immunity

authors： Grawunder U,Leu TM,Schatz DG,Werner A,Rolink AG,Melchers F,Winkler TH

更新日期：1995-11-01 00:00:00

abstract：:Monobenzone is a pro-hapten that is exclusively metabolized by melanocytes, thereby haptenizing melanocyte-specific antigens, which results in cytotoxic autoimmunity specifically against pigmented cells. Studying monobenzone in a setting of contact hypersensitivity (CHS), we observed that monobenzone induced a long-la...

journal_title：Immunity

authors： van den Boorn JG,Jakobs C,Hagen C,Renn M,Luiten RM,Melief CJ,Tüting T,Garbi N,Hartmann G,Hornung V

更新日期：2016-06-21 00:00:00

abstract：:Chimeric antigen receptors (CARs) redirect T cell cytotoxicity against cancer cells, providing a promising approach to cancer immunotherapy. Despite extensive clinical use, the attributes of CAR co-stimulatory domains that impact persistence and resistance to exhaustion of CAR-T cells remain largely undefined. Here, w...

journal_title：Immunity

authors： Kawalekar OU,O'Connor RS,Fraietta JA,Guo L,McGettigan SE,Posey AD Jr,Patel PR,Guedan S,Scholler J,Keith B,Snyder NW,Blair IA,Milone MC,June CH

更新日期：2016-02-16 00:00:00

abstract：:Monocytes are circulating, short-lived mononuclear phagocytes, which in mice and man comprise two main subpopulations. Murine Ly6C+ monocytes display developmental plasticity and are recruited to complement tissue-resident macrophages and dendritic cells on demand. Murine vascular Ly6C- monocytes patrol the endotheliu...

journal_title：Immunity

authors： Mildner A,Schönheit J,Giladi A,David E,Lara-Astiaso D,Lorenzo-Vivas E,Paul F,Chappell-Maor L,Priller J,Leutz A,Amit I,Jung S

更新日期：2017-05-16 00:00:00

abstract：:Several experimental evidences suggested that beta1 integrin-mediated adhesion of hematopoietic stem cells (HSC) is important for their function in the bone marrow (BM). Using induced deletion of the beta1 integrin gene restricted to the hematopoietic system, we show that beta1 integrin is not essential for HSC retent...

journal_title：Immunity

authors： Brakebusch C,Fillatreau S,Potocnik AJ,Bungartz G,Wilhelm P,Svensson M,Kearney P,Körner H,Gray D,Fässler R

更新日期：2002-03-01 00:00:00

abstract：:Macrophage/neutrophil-specific IL-4 receptor alpha-deficient mice (LysM(Cre)IL-4Ralpha(-/flox)) were generated to understand the role of IL-4/IL-13 responsive myeloid cells during Type 2 immune responses. LysM(Cre)IL-4Ralpha(-/flox) mice developed protective immunity against Nippostrongylus brasiliensis accompanied by...

journal_title：Immunity

authors： Herbert DR,Hölscher C,Mohrs M,Arendse B,Schwegmann A,Radwanska M,Leeto M,Kirsch R,Hall P,Mossmann H,Claussen B,Förster I,Brombacher F

更新日期：2004-05-01 00:00:00

abstract：:According to the traditional view, atherosclerosis results from a passive buildup of cholesterol in the artery wall. Yet, burgeoning evidence implicates inflammation and immune effector mechanisms in the pathogenesis of this disease. Both innate and adaptive immunity operate during atherogenesis and link many traditio...

journal_title：Immunity

authors： Libby P,Lichtman AH,Hansson GK

更新日期：2013-06-27 00:00:00

abstract：:Plasmacytoid dendritic cells (pDCs) are primary producers of type I interferon (IFN) in response to viruses. The IFN-producing capacity of pDCs is regulated by specific inhibitory receptors, yet none of the known receptors are conserved in evolution. We report that within the human immune system, receptor protein tyro...

journal_title：Immunity

authors： Bunin A,Sisirak V,Ghosh HS,Grajkowska LT,Hou ZE,Miron M,Yang C,Ceribelli M,Uetani N,Chaperot L,Plumas J,Hendriks W,Tremblay ML,Häcker H,Staudt LM,Green PH,Bhagat G,Reizis B

更新日期：2015-08-18 00:00:00

abstract：:Recent evidence has suggested that signals other than those from Toll-like receptors (TLRs) could contribute to the elicitation of antigen-specific immunity. Therefore, we examined the role of the Nod-like receptor (NLR) family member, Nod1, in the generation of adaptive immune responses. Our findings show that innate...

journal_title：Immunity

authors： Fritz JH,Le Bourhis L,Sellge G,Magalhaes JG,Fsihi H,Kufer TA,Collins C,Viala J,Ferrero RL,Girardin SE,Philpott DJ

更新日期：2007-04-01 00:00:00

abstract：:Inhibition of immune regulatory checkpoints, such as CTLA-4 and the PD-1-PD-L1 axis, is at the forefront of immunotherapy for cancers of various histological types. However, such immunotherapies fail to control neoplasia in a significant proportion of patients. Here, we review how a range of cancer-cell-autonomous cue...

journal_title：Immunity

authors： Pitt JM,Vétizou M,Daillère R,Roberti MP,Yamazaki T,Routy B,Lepage P,Boneca IG,Chamaillard M,Kroemer G,Zitvogel L

更新日期：2016-06-21 00:00:00

abstract：:The cause of common polygenic autoimmune diseases is not understood because of genetic and cellular complexity. Here, we pinpoint the action of a subset of autoimmune susceptibility loci in the NOD mouse strain linked to D1mit181, D2mit490, D7mit101, and D15mit229, which cause a generalized resistance to thymic deleti...

journal_title：Immunity

authors： Liston A,Lesage S,Gray DH,O'Reilly LA,Strasser A,Fahrer AM,Boyd RL,Wilson J,Baxter AG,Gallo EM,Crabtree GR,Peng K,Wilson SR,Goodnow CC

更新日期：2004-12-01 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1)-infected corneas can develop a blinding immunoinflammatory condition called herpes stromal keratitis (HSK), which involves the loss of corneal sensitivity due to retraction of sensory nerves and subsequent hyperinnervation with sympathetic nerves. Increased concentrations of the cyt...

journal_title：Immunity

authors： Yun H,Yee MB,Lathrop KL,Kinchington PR,Hendricks RL,St Leger AJ

更新日期：2020-11-17 00:00:00

abstract：:Fever, an evolutionarily conserved physiological response to infection, is also commonly associated with many autoimmune diseases, but its role in T cell differentiation and autoimmunity remains largely unclear. T helper 17 (Th17) cells are critical in host defense and autoinflammatory diseases, with distinct phenotyp...

journal_title：Immunity

authors： Wang X,Ni L,Wan S,Zhao X,Ding X,Dejean A,Dong C

更新日期：2020-02-18 00:00:00