Protein Tyrosine Phosphatase PTPRS Is an Inhibitory Receptor on Human and Murine Plasmacytoid Dendritic Cells.

abstract：:The elongated complementary-determining region (CDR) 3beta found in the unliganded KB5-C20 TCR protrudes from the antigen binding site and prevents its docking onto the peptide/MHC (pMHC) surface according to a canonical diagonal orientation. We now present the crystal structure of a complex involving the KB5-C20 TCR ...

journal_title：Immunity

authors： Reiser JB,Grégoire C,Darnault C,Mosser T,Guimezanes A,Schmitt-Verhulst AM,Fontecilla-Camps JC,Mazza G,Malissen B,Housset D

更新日期：2002-03-01 00:00:00

abstract：:Recognition of major histocompatibility class I molecules on target cells by natural killer (NK) cells confers selective protection from NK-mediated lysis. Cross-linking of the p58 NK receptor, involved in the recognition of HLA-C alleles, delivers a negative signal that prevents target cell lysis. Molecular cloning o...

journal_title：Immunity

authors： Wagtmann N,Biassoni R,Cantoni C,Verdiani S,Malnati MS,Vitale M,Bottino C,Moretta L,Moretta A,Long EO

更新日期：1995-05-01 00:00:00

abstract：:For several days after antigenic stimulation, human cytolytic T lymphocyte (CTL) clones exhibit a decrease in their effector activity and in their binding to human leukocyte antigen (HLA)-peptide tetramers. We observed that, when in this state, CTLs lose the colocalization of the T cell receptor (TCR) and CD8. Effecto...

journal_title：Immunity

authors： Demotte N,Stroobant V,Courtoy PJ,Van Der Smissen P,Colau D,Luescher IF,Hivroz C,Nicaise J,Squifflet JL,Mourad M,Godelaine D,Boon T,van der Bruggen P

更新日期：2008-03-01 00:00:00

abstract：:To examine the role of the TNF-R superfamily signaling protein TRAF2 in mature B cell development and NF-kappaB activation, conditionally TRAF2-deficient mice were produced. B cells lacking TRAF2 expression in these mice possessed a selective survival advantage, accumulated in the lymph nodes and splenic marginal zone...

journal_title：Immunity

authors： Grech AP,Amesbury M,Chan T,Gardam S,Basten A,Brink R

更新日期：2004-11-01 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs) and cancer stem cells (CSCs) are important cellular components in the cancer microenvironment and may affect cancer phenotype and patient outcome. The nature of MDSCs and their interaction with CSCs in ovarian carcinoma are unclear. We examined the interaction between MDSCs and...

journal_title：Immunity

authors： Cui TX,Kryczek I,Zhao L,Zhao E,Kuick R,Roh MH,Vatan L,Szeliga W,Mao Y,Thomas DG,Kotarski J,Tarkowski R,Wicha M,Cho K,Giordano T,Liu R,Zou W

更新日期：2013-09-19 00:00:00

abstract：:Epithelial cells orchestrate pulmonary homeostasis and pathogen defense and play a crucial role in the initiation of allergic immune responses. Maintaining the balance between homeostasis and inappropriate immune activation and associated pathology is particularly complex at mucosal sites that are exposed to billions ...

journal_title：Immunity

authors： Denney L,Byrne AJ,Shea TJ,Buckley JS,Pease JE,Herledan GM,Walker SA,Gregory LG,Lloyd CM

更新日期：2015-11-17 00:00:00

abstract：:PKCβ-null (Prkcb-/-) mice are severely immunodeficient. Here we show that mice whose B cells lack PKCβ failed to form germinal centers and plasma cells, which undermined affinity maturation and antibody production in response to immunization. Moreover, these mice failed to develop plasma cells in response to viral inf...

journal_title：Immunity

authors： Tsui C,Martinez-Martin N,Gaya M,Maldonado P,Llorian M,Legrave NM,Rossi M,MacRae JI,Cameron AJ,Parker PJ,Leitges M,Bruckbauer A,Batista FD

更新日期：2018-06-19 00:00:00

abstract：:Activation of the transcription factor NF-kappa B and pre-T cell receptor (pre-TCR) expression is tightly correlated during thymocyte development. Inhibition of NF-kappa B in isolated thymocytes in vitro results in spontaneous apoptosis of cells expressing the pre-TCR, whereas inhibition of NF-kappa B in transgenic mi...

journal_title：Immunity

authors： Voll RE,Jimi E,Phillips RJ,Barber DF,Rincon M,Hayday AC,Flavell RA,Ghosh S

更新日期：2000-11-01 00:00:00

abstract：:Antigen-dependent T cell activation drives the formation of signaling microclusters containing the adaptor SLP-76. Costimulatory integrins regulate SLP-76 phosphorylation and could influence SLP-76 microclusters in the integrin-rich periphery of the immune synapse. We report that costimulation by the integrin VLA-4 (a...

journal_title：Immunity

authors： Nguyen K,Sylvain NR,Bunnell SC

更新日期：2008-06-01 00:00:00

abstract：:Fever, an evolutionarily conserved physiological response to infection, is also commonly associated with many autoimmune diseases, but its role in T cell differentiation and autoimmunity remains largely unclear. T helper 17 (Th17) cells are critical in host defense and autoinflammatory diseases, with distinct phenotyp...

journal_title：Immunity

authors： Wang X,Ni L,Wan S,Zhao X,Ding X,Dejean A,Dong C

更新日期：2020-02-18 00:00:00

abstract：:Particulate pollution is thought to function as an adjuvant that can induce allergic responses. However, the exact cell types and immunological factors that initiate the lung-specific immune responses are unclear. We found that upon intratracheal instillation, particulates such as aluminum salts and silica killed alve...

journal_title：Immunity

authors： Kuroda E,Ozasa K,Temizoz B,Ohata K,Koo CX,Kanuma T,Kusakabe T,Kobari S,Horie M,Morimoto Y,Nakajima S,Kabashima K,Ziegler SF,Iwakura Y,Ise W,Kurosaki T,Nagatake T,Kunisawa J,Takemura N,Uematsu S,Hayashi M,Aoshi T

更新日期：2016-12-20 00:00:00

abstract：:Distinct metabolic programs support the differentiation of CD4(+) T cells into separate functional subsets. In this study, we investigated metabolic mechanisms underlying the differentiation of IL-9-producing CD4(+) T cells (Th9) in allergic airway inflammation and cancerous tumors. We found that histone deacetylase S...

journal_title：Immunity

authors： Wang Y,Bi Y,Chen X,Li C,Li Y,Zhang Z,Wang J,Lu Y,Yu Q,Su H,Yang H,Liu G

更新日期：2016-06-21 00:00:00

abstract：:Lymphoid tissue inducer (LTi) cells are key components of the machinery required for the construction of the lymphoid structures underlying immune responses. In this issue of Immunity, Vonarbourg et. al. (2010) describe how these cells assume several different guises, each associated with different LTi functions. ...

journal_title：Immunity

authors： Strober W

更新日期：2010-11-24 00:00:00

abstract：:T helper 17 (Th17) cells play major roles in autoimmunity and bacterial infections, yet how T cell receptor (TCR) signaling affects Th17 cell differentiation is relatively unknown. We demonstrate that CD4(+) T cells lacking Itk, a tyrosine kinase required for full TCR-induced phospholipase C-gamma (PLC-gamma1) activat...

journal_title：Immunity

authors： Gomez-Rodriguez J,Sahu N,Handon R,Davidson TS,Anderson SM,Kirby MR,August A,Schwartzberg PL

更新日期：2009-10-16 00:00:00

abstract：:Kupffer cells (KCs) are liver-resident macrophages that self-renew by proliferation in the adult independently from monocytes. However, how they are maintained during non-alcoholic steatohepatitis (NASH) remains ill defined. We found that a fraction of KCs derived from Ly-6C+ monocytes during NASH, underlying impaired...

journal_title：Immunity

authors： Tran S,Baba I,Poupel L,Dussaud S,Moreau M,Gélineau A,Marcelin G,Magréau-Davy E,Ouhachi M,Lesnik P,Boissonnas A,Le Goff W,Clausen BE,Yvan-Charvet L,Sennlaub F,Huby T,Gautier EL

更新日期：2020-09-15 00:00:00

abstract：:Apoptotic death of T lymphocytes is critical for shutdown of immune responses and hemopoietic cell homeostasis. Both death receptor (Fas) activation and mitochondrial apoptosis triggered by the BH3-only protein Bim have been implicated in the killing of antigen-stimulated T cells. We examined mice lacking the gene enc...

journal_title：Immunity

authors： Hughes PD,Belz GT,Fortner KA,Budd RC,Strasser A,Bouillet P

更新日期：2008-02-01 00:00:00

abstract：:The kinases RIPK1 and RIPK3 and the pseudo-kinase MLKL have been identified as key regulators of the necroptotic cell death pathway, although a role for MLKL within the whole animal has not yet been established. Here, we have shown that MLKL deficiency rescued the embryonic lethality caused by loss of Caspase-8 or FAD...

journal_title：Immunity

authors： Alvarez-Diaz S,Dillon CP,Lalaoui N,Tanzer MC,Rodriguez DA,Lin A,Lebois M,Hakem R,Josefsson EC,O'Reilly LA,Silke J,Alexander WS,Green DR,Strasser A

更新日期：2016-09-20 00:00:00

abstract：:In comparison to murine dendritic cells (DCs), less is known about the function of human DCs in tissues. Here, we analyzed, by using lung tissues from humans and humanized mice, the role of human CD1c(+) and CD141(+) DCs in determining the type of CD8(+) T cell immunity generated to live-attenuated influenza virus (LA...

journal_title：Immunity

authors： Yu CI,Becker C,Wang Y,Marches F,Helft J,Leboeuf M,Anguiano E,Pourpe S,Goller K,Pascual V,Banchereau J,Merad M,Palucka K

更新日期：2013-04-18 00:00:00

abstract：:We and others have defined a transcriptional silencer critical for the proper expression of the CD4 gene at all stages of T cell development. In this report, we use biochemical techniques to identify three different factor-binding sites within the CD4 silencer, denoted sites I, II, and III. Using transgenic analyses, ...

journal_title：Immunity

authors： Duncan DD,Adlam M,Siu G

更新日期：1996-03-01 00:00:00

abstract：:B cell subsets expressing the transcription factor T-bet are associated with humoral immune responses and autoimmunity. Here, we examined the anatomic distribution, clonal relationships, and functional properties of T-bet+ and T-bet- memory B cells (MBCs) in the context of the influenza-specific immune response. In mi...

journal_title：Immunity

authors： Johnson JL,Rosenthal RL,Knox JJ,Myles A,Naradikian MS,Madej J,Kostiv M,Rosenfeld AM,Meng W,Christensen SR,Hensley SE,Yewdell J,Canaday DH,Zhu J,McDermott AB,Dori Y,Itkin M,Wherry EJ,Pardi N,Weissman D,Naji A,Pra

更新日期：2020-05-19 00:00:00

abstract：:Antigen presentation and microbial killing are critical arms of host defense that depend upon cargo trafficking into lysosomes. Yet, the molecular regulators of traffic into lysosomes are only partly understood. Here, using a lysosome-dependent immunological screen of a trafficking shRNA library, we identified the Arf...

journal_title：Immunity

authors： Garg S,Sharma M,Ung C,Tuli A,Barral DC,Hava DL,Veerapen N,Besra GS,Hacohen N,Brenner MB

更新日期：2011-08-26 00:00:00

abstract：:Latent and activated forms of Stat1 and Stat6 have been expressed and purified, enabling biochemical experiments relating to their functional activities. Stat1 bound to a phosphotyrosine peptide derived from the IFN gamma receptor with a KD of 50 nM, whereas Stat6 bound to an IL-4 receptor peptide with a KD of 300 nM....

journal_title：Immunity

authors： Schindler U,Wu P,Rothe M,Brasseur M,McKnight SL

更新日期：1995-06-01 00:00:00

abstract：:The structure of H-2Dd complexed with the HIV-derived peptide P18-I10 (RGPGRAFVTI) has been determined by X-ray crystallography at 2.4 A resolution. This MHC class I molecule has an unusual binding motif with four anchor residues in the peptide (G2, P3, R/K/H5, and I/L/F9 or 10). The cleft architecture of H-2Dd includ...

journal_title：Immunity

authors： Achour A,Persson K,Harris RA,Sundbäck J,Sentman CL,Lindqvist Y,Schneider G,Kärre K

更新日期：1998-08-01 00:00:00

abstract：:Toll-like receptor-9 (TLR9) is largely responsible for discriminating self from pathogenic DNA. However, association of host DNA with autoantibodies activates TLR9, inducing the pathogenic secretion of type I interferons (IFNs) from plasmacytoid dendritic cells (pDCs). Here, we found that in response to DNA-containing...

journal_title：Immunity

authors： Henault J,Martinez J,Riggs JM,Tian J,Mehta P,Clarke L,Sasai M,Latz E,Brinkmann MM,Iwasaki A,Coyle AJ,Kolbeck R,Green DR,Sanjuan MA

更新日期：2012-12-14 00:00:00

abstract：:MicroRNAs have been shown to be critical for a number of aspects of immune system regulation and function. Here, we have examined the role of microRNAs in terminal B cell differentiation by analyzing Cd19-Cre(ki/+) Dicer1(fl/fl) mice. We found that in the absence of Dicer, the transitional and marginal zone (MZ) B cel...

journal_title：Immunity

authors： Belver L,de Yébenes VG,Ramiro AR

更新日期：2010-11-24 00:00:00

abstract：:Among 631 substitutions present in 90 nurse shark immunoglobulin light chain somatic mutants, 338 constitute 2-4 bp stretches of adjacent changes. An absence of mutations in perinatal sequences and the bias for one mutating V gene in adults suggest that the diversification is antigen dependent. The substitutions share...

journal_title：Immunity

authors： Lee SS,Tranchina D,Ohta Y,Flajnik MF,Hsu E

更新日期：2002-04-01 00:00:00

abstract：:Recognition of bacterial peptidoglycan by the Drosophila IMD pathway triggers NF-κB activation and an associated immune response. In this issue of Immunity, Kleino et al. (2017) show that proteins in the IMD pathway form functional amyloids via a cryptic motif resembling the RHIM motif found in mammalian RIPK proteins...

journal_title：Immunity

authors： Shin S,Cherry S

更新日期：2017-10-17 00:00:00

abstract：:Higher- or lower-affinity germinal center (GC) B cells are directed either to plasma cell or GC recycling, respectively; however, how commitment to the plasma cell fate takes place is unclear. We found that a population of light zone (LZ) GC cells, Bcl6loCD69hi expressing a transcription factor IRF4 and higher-affinit...

journal_title：Immunity

authors： Ise W,Fujii K,Shiroguchi K,Ito A,Kometani K,Takeda K,Kawakami E,Yamashita K,Suzuki K,Okada T,Kurosaki T

更新日期：2018-04-17 00:00:00

abstract：:A tumor-specific CD8+ T cell response was studied using adoptive transfer of OT-I TCR transgenic cells. Upon i.p. challenge with E.G7 tumor, OT-I cells undergo CD4+ T cell-independent expansion at the tumor site and develop lytic function. Before tumor elimination, however, they leave the peritoneal cavity (PC) and ap...

journal_title：Immunity

authors： Shrikant P,Khoruts A,Mescher MF

更新日期：1999-10-01 00:00:00

abstract：:The Foxp3+ T cell lineage is thought to arise from self-specific precursors during development. By using a unique mouse model, Pacholczyk et al. (2007) present compelling evidence that self-specific cells are exceedingly rare among Foxp3(-) and, surprisingly, Foxp3+ subsets. ...

journal_title：Immunity

authors： Stephens GL,Shevach EM

更新日期：2007-09-01 00:00:00