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A RHIM with a View: FLYing with Functional Amyloids.

Abstract：

:Recognition of bacterial peptidoglycan by the Drosophila IMD pathway triggers NF-κB activation and an associated immune response. In this issue of Immunity, Kleino et al. (2017) show that proteins in the IMD pathway form functional amyloids via a cryptic motif resembling the RHIM motif found in mammalian RIPK proteins. Amyloid formation can be negatively regulated, suggesting that it presents a regulatory point in multiple biological processes.

journal_name

Immunity

journal_title

Immunity

authors

Shin S,Cherry S

doi

10.1016/j.immuni.2017.10.001

subject

Has Abstract

pub_date

2017-10-17 00:00:00

pages

604-606

issue

4

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(17)30432-6

journal_volume

47

pub_type

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