Abstract：
:Activation of the transcription factor NF-kappa B and pre-T cell receptor (pre-TCR) expression is tightly correlated during thymocyte development. Inhibition of NF-kappa B in isolated thymocytes in vitro results in spontaneous apoptosis of cells expressing the pre-TCR, whereas inhibition of NF-kappa B in transgenic mice through expression of a mutated, superrepressor form of I kappa B alpha leads to a loss of beta-selected thymocytes. In contrast, the forced activation of NF-kappa B through expression of a dominant-active I kappa B kinase allows differentiation to proceed to the CD4(+)CD8(+) stage in a Rag1(-/-) mouse that cannot assemble the pre-TCR. Therefore, signals emanating from the pre-TCR are mediated at least in part by NF-kappa B, which provides a selective survival signal for developing thymocytes with productive beta chain rearrangements.
journal_name
Immunityjournal_title
Immunityauthors
Voll RE,Jimi E,Phillips RJ,Barber DF,Rincon M,Hayday AC,Flavell RA,Ghosh Sdoi
10.1016/s1074-7613(00)00067-4keywords:
subject
Has Abstractpub_date
2000-11-01 00:00:00pages
677-89issue
5eissn
1074-7613issn
1097-4180pii
S1074-7613(00)00067-4journal_volume
13pub_type
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