当前位置： SCI文献检索 > IMMUNITY期刊下所有文献 > TIM-1 glycoprotein binds the adhesion receptor P-selectin and mediates T cell trafficking during inflammation and autoimmunity.

TIM-1 glycoprotein binds the adhesion receptor P-selectin and mediates T cell trafficking during inflammation and autoimmunity.

Abstract：

:Selectins play a central role in leukocyte trafficking by mediating tethering and rolling on vascular surfaces. Here we have reported that T cell immunoglobulin and mucin domain 1 (TIM-1) is a P-selectin ligand. We have shown that human and murine TIM-1 binds to P-selectin, and that TIM-1 mediates tethering and rolling of T helper 1 (Th1) and Th17, but not Th2 and regulatory T cells on P-selectin. Th1 and Th17 cells lacking the TIM-1 mucin domain showed reduced rolling in thrombin-activated mesenteric venules and inflamed brain microcirculation. Inhibition of TIM-1 had no effect on naive T cell homing, but it reduced T cell recruitment in a skin hypersensitivity model and blocked experimental autoimmune encephalomyelitis. Uniquely, the TIM-1 immunoglobulin variable domain was also required for P-selectin binding. Our data demonstrate that TIM-1 is a major P-selectin ligand with a specialized role in T cell trafficking during inflammatory responses and the induction of autoimmune disease.

journal_name

Immunity

journal_title

Immunity

authors

Angiari S,Donnarumma T,Rossi B,Dusi S,Pietronigro E,Zenaro E,Della Bianca V,Toffali L,Piacentino G,Budui S,Rennert P,Xiao S,Laudanna C,Casasnovas JM,Kuchroo VK,Constantin G

doi

10.1016/j.immuni.2014.03.004

subject

Has Abstract

pub_date

2014-04-17 00:00:00

pages

542-53

issue

4

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(14)00084-3

journal_volume

40

pub_type

杂志文章

相关文献

IMMUNITY文献大全
  • Class switch recombination and somatic hypermutation in early mouse B cells are mediated by B cell and Toll-like receptors.

    abstract：:Activation-induced cytidine deaminase (AID) is required for immunoglobulin (Ig) gene class switch recombination (CSR), somatic hypermutation (SHM), and somatic hyperconversion. In general, high AID expression is found in mature B cells that are responding to antigens. However, AID expression and SHM have also been det...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2007.05.018

    authors： Han JH,Akira S,Calame K,Beutler B,Selsing E,Imanishi-Kari T

    更新日期：2007-07-01 00:00:00

  • Rapid expansion and IL-4 expression by Leishmania-specific naive helper T cells in vivo.

    abstract：:CD4 T cells are pivotal for effective immunity, yet their initial differentiation into effector subsets after infection remains poorly defined. We examined CD4 T cells specific for the immunodominant Leishmania major LACK antigen using MHC/peptide tetramers and IL-4 reporter mice. Comprising approximately 15 cells/lym...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(02)00363-1

    authors： Stetson DB,Mohrs M,Mallet-Designe V,Teyton L,Locksley RM

    更新日期：2002-08-01 00:00:00

  • 2.8 A resolution crystal structure of human TRAIL, a cytokine with selective antitumor activity.

    abstract：:TRAIL is a newly identified cytokine belonging to the large tumor necrosis factor (TNF) family. TRAIL is a novel molecule inducing apoptosis in a wide variety of tumor cells but not in normal cells. To help in elucidating its biological roles and designing mutants with improved therapeutic potential, we have determine...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80100-4

    authors： Cha SS,Kim MS,Choi YH,Sung BJ,Shin NK,Shin HC,Sung YC,Oh BH

    更新日期：1999-08-01 00:00:00

  • Boosting Apoptotic Cell Clearance by Colonic Epithelial Cells Attenuates Inflammation In Vivo.

    abstract：:Few apoptotic corpses are seen even in tissues with high cellular turnover, leading to the notion that the capacity for engulfment in vivo is vast. Whether corpse clearance can be enhanced in vivo for potential benefit is not known. In a colonic inflammation model, we noted that the expression of the phagocytic recept...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2016.02.005

    authors： Lee CS,Penberthy KK,Wheeler KM,Juncadella IJ,Vandenabeele P,Lysiak JJ,Ravichandran KS

    更新日期：2016-04-19 00:00:00

  • Bacterial infections promote T cell recognition of self-glycolipids.

    abstract：:Recognition of self is essential for repertoire selection, immune regulation, and autoimmunity and may be a consequence of infection. Self-induced recognition may represent the escape mechanism adopted by pathogens but may also incite autoimmune diseases. Here, we show that bacterial infection may promote activation o...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2005.04.013

    authors： De Libero G,Moran AP,Gober HJ,Rossy E,Shamshiev A,Chelnokova O,Mazorra Z,Vendetti S,Sacchi A,Prendergast MM,Sansano S,Tonevitsky A,Landmann R,Mori L

    更新日期：2005-06-01 00:00:00

  • Oxidation of cofilin mediates T cell hyporesponsiveness under oxidative stress conditions.

    abstract：:Oxidative stress leads to impaired T cell activation. A central integrator of T cell activation is the actin-remodelling protein cofilin. Cofilin is activated through dephosphorylation at Ser3. Activated cofilin enables actin dynamics through severing and depolymerization of F-actin. Binding of cofilin to actin is req...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2008.06.016

    authors： Klemke M,Wabnitz GH,Funke F,Funk B,Kirchgessner H,Samstag Y

    更新日期：2008-09-19 00:00:00

  • F-actin is an evolutionarily conserved damage-associated molecular pattern recognized by DNGR-1, a receptor for dead cells.

    abstract：:Sterile inflammation can be initiated by innate immune recognition of markers of tissue injury termed damage-associated molecular patterns (DAMPs). DAMP recognition by dendritic cells (DCs) has also been postulated to lead to T cell responses to foreign antigens in tumors or allografts. Many DAMPs represent intracellu...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2012.03.008

    authors： Ahrens S,Zelenay S,Sancho D,Hanč P,Kjær S,Feest C,Fletcher G,Durkin C,Postigo A,Skehel M,Batista F,Thompson B,Way M,Reis e Sousa C,Schulz O

    更新日期：2012-04-20 00:00:00

  • Pathogen recognition: TLRs throw us a curve.

    abstract：:Toll-like receptors (TLRs) are the archetypal pattern recognition receptors (PRRs) envisioned by as innate sensors of pathogen attack and host triggers of an adaptive immune response. Two recent papers (Choe et al., 2005; Bell et al., 2005) reveal the distinctive architecture of a TLR sensor domain and hint at how thi...

    journal_title：Immunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.immuni.2005.09.008

    authors： Kirk P,Bazan JF

    更新日期：2005-10-01 00:00:00

  • Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim.

    abstract：:The cause of common polygenic autoimmune diseases is not understood because of genetic and cellular complexity. Here, we pinpoint the action of a subset of autoimmune susceptibility loci in the NOD mouse strain linked to D1mit181, D2mit490, D7mit101, and D15mit229, which cause a generalized resistance to thymic deleti...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2004.10.014

    authors： Liston A,Lesage S,Gray DH,O'Reilly LA,Strasser A,Fahrer AM,Boyd RL,Wilson J,Baxter AG,Gallo EM,Crabtree GR,Peng K,Wilson SR,Goodnow CC

    更新日期：2004-12-01 00:00:00

  • IL-33 Deals with the Gray Matter.

    abstract：:The central nervous system undergoes extensive postnatal synapse remodeling that is critical for the formation of mature neural circuits. In a recent issue of Science, Vainchtein et al. (2018) describe an additional role for astrocyte-derived interleukin-33 (IL-33) in promoting synapse refinement by microglia in the d...

    journal_title：Immunity

    pub_type： 信件

    doi：10.1016/j.immuni.2018.03.005

    authors： Delmas C,Dalmas E

    更新日期：2018-03-20 00:00:00

  • Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors.

    abstract：:Monocytes are effectors of the inflammatory response to microbes. Human CD14(+) monocytes specialize in phagocytosis and production of reactive oxygen species and secrete inflammatory cytokines in response to a broad range of microbial cues. Here, we have characterized the functions of human monocytes that lack CD14 (...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2010.08.012

    authors： Cros J,Cagnard N,Woollard K,Patey N,Zhang SY,Senechal B,Puel A,Biswas SK,Moshous D,Picard C,Jais JP,D'Cruz D,Casanova JL,Trouillet C,Geissmann F

    更新日期：2010-09-24 00:00:00

  • Interleukin-18 in intestinal inflammation: friend and foe?

    abstract：:Genetic studies and other experimental data have linked inflammatory bowel diseases with inflammasome activation. In this issue of Immunity, Zaki et al. (2010) and Dupaul-Chicoine et al. (2010) provide a detailed characterization of the regulatory task of the inflammasome in intestinal epithelial cells. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2010.03.010

    authors： Siegmund B

    更新日期：2010-03-26 00:00:00

  • Production of the Cytokine VEGF-A by CD4+ T and Myeloid Cells Disrupts the Corneal Nerve Landscape and Promotes Herpes Stromal Keratitis.

    abstract：:Herpes simplex virus type 1 (HSV-1)-infected corneas can develop a blinding immunoinflammatory condition called herpes stromal keratitis (HSK), which involves the loss of corneal sensitivity due to retraction of sensory nerves and subsequent hyperinnervation with sympathetic nerves. Increased concentrations of the cyt...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2020.10.013

    authors： Yun H,Yee MB,Lathrop KL,Kinchington PR,Hendricks RL,St Leger AJ

    更新日期：2020-11-17 00:00:00

  • Dichotomous Expression of TNF Superfamily Ligands on Antigen-Presenting Cells Controls Post-priming Anti-viral CD4+ T Cell Immunity.

    abstract：:T cell antigen-presenting cell (APC) interactions early during chronic viral infection are crucial for determining viral set point and disease outcome, but how and when different APC subtypes contribute to these outcomes is unclear. The TNF receptor superfamily (TNFRSF) member GITR is important for CD4+ T cell accumul...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2017.10.014

    authors： Chang YH,Wang KC,Chu KL,Clouthier DL,Tran AT,Torres Perez MS,Zhou AC,Abdul-Sater AA,Watts TH

    更新日期：2017-11-21 00:00:00

  • Microglia Get a Little Help from "Th"-eir Friends.

    abstract：:The presence of CD4+ T cells in the healthy brain parenchyma remains controversial due to the barrier function of the glia limitans. Pasciuto, Burton, Roca et al. in Cell describe the dynamic recruitment of CD4+ T cells within the brain parenchyma, their unexpected contribution to microglial maturation, and, ultimatel...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2020.08.011

    authors： Locatelli G,Engelhardt B

    更新日期：2020-09-15 00:00:00

  • Interleukin-10 Directly Inhibits CD8+ T Cell Function by Enhancing N-Glycan Branching to Decrease Antigen Sensitivity.

    abstract：:Chronic viral infections remain a global health concern. The early events that facilitate viral persistence have been linked to the activity of the immunoregulatory cytokine IL-10. However, the mechanisms by which IL-10 facilitates the establishment of chronic infection are not fully understood. Herein, we demonstrate...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2018.01.006

    authors： Smith LK,Boukhaled GM,Condotta SA,Mazouz S,Guthmiller JJ,Vijay R,Butler NS,Bruneau J,Shoukry NH,Krawczyk CM,Richer MJ

    更新日期：2018-02-20 00:00:00

  • Superficial Immunity: Antimicrobial Responses Are More Than Skin Deep.

    abstract：:The skin barrier is essential for host defense, but how the skin provides protection when the barrier is breached is not well understood. In this issue of Immunity, Gallo and colleagues report that keratinocytes integrate signals from antimicrobial peptides via MAVS signaling to amplify their antiviral immune response...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2016.07.001

    authors： Mack MR,Kim BS

    更新日期：2016-07-19 00:00:00

  • Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production.

    abstract：:Pancreatic-islet inflammation contributes to the failure of β cell insulin secretion during obesity and type 2 diabetes. However, little is known about the nature and function of resident immune cells in this context or in homeostasis. Here we show that interleukin (IL)-33 was produced by islet mesenchymal cells and e...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2017.10.015

    authors： Dalmas E,Lehmann FM,Dror E,Wueest S,Thienel C,Borsigova M,Stawiski M,Traunecker E,Lucchini FC,Dapito DH,Kallert SM,Guigas B,Pattou F,Kerr-Conte J,Maechler P,Girard JP,Konrad D,Wolfrum C,Böni-Schnetzler M,Finke D,D

    更新日期：2017-11-21 00:00:00

  • A lysosomal protein negatively regulates surface T cell antigen receptor expression by promoting CD3zeta-chain degradation.

    abstract：:Modulation of surface T cell antigen receptor (TCR) expression is an important mechanism for the regulation of immune responses and the prevention of T cell hyperactivation and autoimmunity. The TCR is rapidly internalized after antigen stimulation and then degraded in lysosomes. However, few of the molecules involved...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2008.04.024

    authors： Ouchida R,Yamasaki S,Hikida M,Masuda K,Kawamura K,Wada A,Mochizuki S,Tagawa M,Sakamoto A,Hatano M,Tokuhisa T,Koseki H,Saito T,Kurosaki T,Wang JY

    更新日期：2008-07-18 00:00:00

  • Lactobacillus-Deficient Cervicovaginal Bacterial Communities Are Associated with Increased HIV Acquisition in Young South African Women.

    abstract：:Elevated inflammation in the female genital tract is associated with increased HIV risk. Cervicovaginal bacteria modulate genital inflammation; however, their role in HIV susceptibility has not been elucidated. In a prospective cohort of young, healthy South African women, we found that individuals with diverse genita...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2016.12.013

    authors： Gosmann C,Anahtar MN,Handley SA,Farcasanu M,Abu-Ali G,Bowman BA,Padavattan N,Desai C,Droit L,Moodley A,Dong M,Chen Y,Ismail N,Ndung'u T,Ghebremichael MS,Wesemann DR,Mitchell C,Dong KL,Huttenhower C,Walker BD,Virgi

    更新日期：2017-01-17 00:00:00

  • Nef-mediated lipid raft exclusion of UbcH7 inhibits Cbl activity in T cells to positively regulate signaling.

    abstract：:Lentiviral Nef increases T cell signaling activity, but the molecular nature of the stimulus involved is incompletely described. We explored CD4 T cell lipid raft composition in the presence and absence of Nef. Here, the E2 ubiquitin-conjugating enzyme UbcH7, which acts in conjunction with c-Cbl, is absent from lipid ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2005.11.003

    authors： Simmons A,Gangadharan B,Hodges A,Sharrocks K,Prabhakar S,García A,Dwek R,Zitzmann N,McMichael A

    更新日期：2005-12-01 00:00:00

  • Interleukin-17A Serves a Priming Role in Autoimmunity by Recruiting IL-1β-Producing Myeloid Cells that Promote Pathogenic T Cells.

    abstract：:Interleukin-17A (IL-17A) is a major mediator of tissue inflammation in many autoimmune diseases. Anti-IL-17A is an effective treatment for psoriasis and is showing promise in clinical trials in multiple sclerosis. In this study, we find that IL-17A-defective mice or mice treated with anti-IL-17A at induction of experi...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2020.01.002

    authors： McGinley AM,Sutton CE,Edwards SC,Leane CM,DeCourcey J,Teijeiro A,Hamilton JA,Boon L,Djouder N,Mills KHG

    更新日期：2020-02-18 00:00:00

  • Histone Deacetylase SIRT1 Negatively Regulates the Differentiation of Interleukin-9-Producing CD4(+) T Cells.

    abstract：:Distinct metabolic programs support the differentiation of CD4(+) T cells into separate functional subsets. In this study, we investigated metabolic mechanisms underlying the differentiation of IL-9-producing CD4(+) T cells (Th9) in allergic airway inflammation and cancerous tumors. We found that histone deacetylase S...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2016.05.009

    authors： Wang Y,Bi Y,Chen X,Li C,Li Y,Zhang Z,Wang J,Lu Y,Yu Q,Su H,Yang H,Liu G

    更新日期：2016-06-21 00:00:00

  • Silence of the ROS.

    abstract：:Reactive oxygen species (ROS) are generated during T cell activation and serve a signaling function but can also be damaging. In this issue of Immunity, Zhang et al. (2016) show that miR-23a prevents ROS-elicited necrosis by suppressing cyclophilin D (PPIF), a regulator of ROS escape from mitochondria. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2016.02.027

    authors： Agudo J,Brown BD

    更新日期：2016-03-15 00:00:00

  • CCR6 Defines Memory B Cell Precursors in Mouse and Human Germinal Centers, Revealing Light-Zone Location and Predominant Low Antigen Affinity.

    abstract：:Memory B cells (MBCs) and plasma cells (PCs) constitute the two cellular outputs of germinal center (GC) responses that together facilitate long-term humoral immunity. Although expression of the transcription factor BLIMP-1 identifies cells undergoing PC differentiation, no such marker exists for cells committed to th...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2017.11.022

    authors： Suan D,Kräutler NJ,Maag JLV,Butt D,Bourne K,Hermes JR,Avery DT,Young C,Statham A,Elliott M,Dinger ME,Basten A,Tangye SG,Brink R

    更新日期：2017-12-19 00:00:00

  • Down-regulation of IL-4 gene transcription and control of Th2 cell differentiation by a mechanism involving NFAT1.

    abstract：:Transcription factors of the NFAT family play a critical role in the immune response by activating the expression of cytokines and other inducible genes in antigen-stimulated cells. Here we show that a member of this family, NFAT1, is involved in down-regulating the late phase of IL-4 gene transcription, thus inhibiti...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80403-3

    authors： Kiani A,Viola JP,Lichtman AH,Rao A

    更新日期：1997-12-01 00:00:00

  • ICOS coreceptor signaling inactivates the transcription factor FOXO1 to promote Tfh cell differentiation.

    abstract：:T follicular helper (Tfh) cells are essential in the induction of high-affinity, class-switched antibodies. The differentiation of Tfh cells is a multi-step process that depends upon the co-receptor ICOS and the activation of phosphoinositide-3 kinase leading to the expression of key Tfh cell genes. We report that ICO...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2015.01.017

    authors： Stone EL,Pepper M,Katayama CD,Kerdiles YM,Lai CY,Emslie E,Lin YC,Yang E,Goldrath AW,Li MO,Cantrell DA,Hedrick SM

    更新日期：2015-02-17 00:00:00

  • T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development.

    abstract：:The transcription factor Foxp3 is essential for the development of regulatory T (Treg) cells, yet its expression is insufficient for establishing the Treg cell lineage. Here we showed that Treg cell development was achieved by the combination of two independent processes, i.e., the expression of Foxp3 and the establis...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2012.09.010

    authors： Ohkura N,Hamaguchi M,Morikawa H,Sugimura K,Tanaka A,Ito Y,Osaki M,Tanaka Y,Yamashita R,Nakano N,Huehn J,Fehling HJ,Sparwasser T,Nakai K,Sakaguchi S

    更新日期：2012-11-16 00:00:00

  • The cellular mechanism of Aire control of T cell tolerance.

    abstract：:Aire promotes the tolerization of thymocytes by inducing the expression of a battery of peripheral-tissue antigens in thymic medullary epithelial cells. We demonstrate that the cellular mechanism by which Aire exerts its tolerance-promoting function is not primarily positive selection of regulatory T cells, but rather...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2005.07.005

    authors： Anderson MS,Venanzi ES,Chen Z,Berzins SP,Benoist C,Mathis D

    更新日期：2005-08-01 00:00:00

  • Protein Tyrosine Phosphatase PTPRS Is an Inhibitory Receptor on Human and Murine Plasmacytoid Dendritic Cells.

    abstract：:Plasmacytoid dendritic cells (pDCs) are primary producers of type I interferon (IFN) in response to viruses. The IFN-producing capacity of pDCs is regulated by specific inhibitory receptors, yet none of the known receptors are conserved in evolution. We report that within the human immune system, receptor protein tyro...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2015.07.009

    authors： Bunin A,Sisirak V,Ghosh HS,Grajkowska LT,Hou ZE,Miron M,Yang C,Ceribelli M,Uetani N,Chaperot L,Plumas J,Hendriks W,Tremblay ML,Häcker H,Staudt LM,Green PH,Bhagat G,Reizis B

    更新日期：2015-08-18 00:00:00